Results 201 to 210 of about 143,872 (300)

Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation

The FEBS Journal, EarlyView.
Structural basis of inactive and active states of the Nedd4 HECT E3 ligase subfamily, following a ‘lock, relax, load, and shoot’ mechanism. In the locked, autoinhibited state, intramolecular domain interactions restrain the HECT domain. Relaxation releases these restraints, allowing loading of ubiquitin onto the catalytic cysteine, followed by the ...
Masa Janosev, Tomas Obsil, Veronika Obsilova   +2 more
wiley   +1 more source

Tau Biomolecular condensates

Tau Biomolecular ...
openaire   +1 more source

Pre-assembly of biomolecular condensate seeds drives RSV replication. [PDF]

Nature
Ratnayake D, Galloux M, Boersma S, Noerenberg M, Sizun C, Sacristan C, Sourimant J, Lakerveld AJ, Gelderloos AT, Apperloo L, Demyanenko Y, Baars MJD, Banerjee R, Dreier B, Furler S, Mazur NI, Bont LJ, Mohammed S, Plückthun A, Éléouët JF, Kops GJPL, Castello A, van Kasteren PB, Rameix-Welti MA, Tanenbaum ME.   +24 more
europepmc   +1 more source

Harnessing S. cerevisiae to advance the engineering of pentatricopeptide repeat proteins

The FEBS Journal, EarlyView.
Heterologous expression systems have been instrumental in furthering our understanding of plant RNA editing proteins. In this commentary, we discuss how the establishment of yeast as a model for studying plant RNA editing by Ramanathan et al. could advance the engineering of pentatricopeptide repeat proteins, and how in return pentatricopeptide repeat ...
Farley M. Kwok van der Giezen, Ian Small
wiley   +1 more source

Phase separation and biomolecular condensate formation drive plant endomembrane and autophagy crosstalk. [PDF]

J Exp Bot
Mgbechidinma CL, Cao J, Jiang L.
europepmc   +1 more source

Bex1 is essential for ciliogenesis and harbours biomolecular condensate-forming capacity. [PDF]

BMC Biol, 2022
Hibino E, Ichiyama Y, Tsukamura A, Senju Y, Morimune T, Ohji M, Maruo Y, Nishimura M, Mori M, Mori M.   +9 more
europepmc   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Mechanistic insights into HapC: A key enzyme in prodiginine biosynthesis in Hahella chejuensis

The FEBS Journal, EarlyView.
HapC catalyzes prodiginine biosynthesis through coordinated movements of its ATP‐binding, substrate‐binding, and catalytic‐swivel domains. The enzyme shows tolerance toward short‐chain MAP analogs, and docking analyses reveal key residues and structural features underlying its substrate flexibility.
Yueh‐Te Chan, Aden Dhana Rizkita, Hsin‐Ju Hsieh, Shu‐Fang Hsu, Tony Eight Lin, Wei‐Jan Huang, Kai‐Cheng Hsu, Sheila Nathan, Peiching Chang, Andrew H.‐J. Wang, Cheng‐Chung Lee   +10 more
wiley   +1 more source

Non-invasive measurement of biomolecular condensate interfacial tension and bending rigidity. [PDF]

Cell Rep Methods
Williamson TA, Law JO, Stevenson T, Wolf F, Jones CM, Tønnessen ES, Grellscheid SN, Kusumaatmaja H.   +7 more
europepmc   +1 more source

Ultrafast python‐integrated single‐entity electrochemical sensor for detecting glycated albumin

The FEBS Journal, EarlyView.
Traditional biosensors suffer from the fact that recognition receptors are immobilised and that they denature on electrodes. Instead here we use receptors freely in solution, minimising surface compression and preserving activity to boost signal efficiency. Python‐driven processing turns the electrochemical response into a rapid, robust readout.
Zihni Onur Uygun
wiley   +1 more source