Abstract Molecular simulation techniques have become an invaluable tool for elucidating the fundamental principles of life at the molecular level. After nearly five decades of development, biomolecular simulations have evolved to enable the quantitative characterization of complex biomolecular events, such as protein folding, conformational dynamics ...
Wenfei Li, Wei Wang
wiley +1 more source
Stress changes the material state of a bacterial biomolecular condensate and shifts its function from mRNA decay to storage. [PDF]
Ortiz-Rodríguez LA +8 more
europepmc +1 more source
Intercompartmental communication in senescence
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz +3 more
wiley +1 more source
Molecular mechanisms of biomolecular condensate formation in Drosophila melanogaster siRNA biogenesis. [PDF]
Hipp C +11 more
europepmc +1 more source
A Comprehensive Review of Waste‐Derived Materials for Solar Still Performance Enhancement
Solar desalination reduces energy use and produces freshwater sustainably, but its productivity is limited and cannot meet rising demand. Thus, solar desalination system improvements are sought to boost water productivity. Waste materials are abundantly available and burden the environment, making them low‐cost enhancers for solar desalination systems.
A. S. Abdullah +6 more
wiley +1 more source
Nonequilibrium phases of a biomolecular condensate facilitated by enzyme activity.
Coupe S, Fakhri N.
europepmc +1 more source
Long-term effect of weight loss induced by bariatric surgery on asthma control and health related quality of life in asthmatic patients with severe obesity: A pilot study [PDF]
Faraone, Stanislao +6 more
core +1 more source
Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li +11 more
wiley +1 more source
Living Hydrogels: Harnessing Microorganism–Material Synergy for Next‐Generation Therapeutics
. ABSTRACT Microorganism‐based therapies, particularly those utilizing probiotics, have emerged as a powerful biomedical strategy owing to their inherent living functionalities. These living systems can dynamically interact with host environments and self‐regulate their activity, offering superior adaptability, prolonged functionality, and ...
Shuifang Mao +3 more
wiley +1 more source
Quantification of Small Molecule Partitioning in a Biomolecular Condensate with 2D Nuclear Magnetic Resonance Spectroscopy. [PDF]
Buhl JM +3 more
europepmc +1 more source

