Results 231 to 240 of about 116,047 (273)
Chemistry – A European Journal, Volume 32, Issue 40, 27 October 2026.We present a two‐dimensional conductive metal‐organic framework (2D cMOF) constructed from an organic linker with lower symmetry than those commonly used in related systems. The resulting reduction in lattice symmetry lifts band degeneracies, reshapes the electronic structure, and opens a larger band gap.
Bowen Tan +4 more
wiley +1 more source
Chemistry – A European Journal, Volume 32, Issue 40, 27 October 2026.In this study, we present a novel method to investigate the phase behavior of biomolecular condensates in living cells. The method complements FRAP experiments, expanding the existing toolbox for characterization of condensates within living cells. ABSTRACT Metabolic enzymes can operate in concerted networks, so‐called metabolons.
Morten Mosbach +3 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.DE‐CQ, an NAD(P)H‐activatable theranostic probe, enables the quantification of cancer aggressiveness via glucose‐stimulated fluorescence imaging and selectively induces apoptosis. Its multifaceted efficacy is demonstrated across 2D cells, 3D spheroids, and in vivo models.
Yujin Cha +11 more
wiley +2 more sources
ChemBioChem, Volume 27, Issue 19, 14 October 2026.A five‐enzyme chemoenzymatic synthesis of the insect‐repellent (4R,7R)‐zingiberene from the wild tomato (Solanum habrochaites) has been developed. This approach enabled the elucidation of the sesquiterpene synthase cyclization mechanism of (2Z,6Z)‐farnesyl pyrophosphate and bypasses classic biosynthetic constraints of prenyltransferase chain extension ...
Luke A. Johnson +6 more
wiley +1 more source
Chemistry – A European Journal, Volume 32, Issue 38, 13 October 2026.ATP itself is able to undergo liquid–liquid phase separation in the presence of the macromolecular crowding agent PEG and physiological ATP concentrations are sufficient for phase separation in the presence of mM Mg2+ and crowders, mimicking intracellular conditions.
Robert Dec +2 more
wiley +1 more source
Angewandte Chemie International Edition, Volume 65, Issue 41, 5 October 2026.Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon +9 more
wiley +1 more source
Biomolecular Condensates and Cancer [PDF]
Cancer Cell, 2021 Malignant transformation is characterized by dysregulation of diverse cellular processes that have been the subject of detailed genetic, biochemical, and structural studies, but only recently has evidence emerged that many of these processes occur in the context of biomolecular condensates.
Isaac A Klein +2 more
exaly +5 more sources
Biomolecular Condensates at the Nexus of Cellular Stress, Protein Aggregation Disease and Ageing
Nature Reviews Molecular Cell Biology, 2021 Biomolecular condensates are membraneless intracellular assemblies that often form via liquid-liquid phase separation and have the ability to concentrate biopolymers. Research over the past 10 years has revealed that condensates play fundamental roles in
Anthony Hyman, Simon Alberti
exaly +2 more sources
Biomolecular Condensates in the Nucleus [PDF]
Trends in Biochemical Sciences, 2020 Nuclear processes such as DNA replication, transcription, and RNA processing each depend on the concerted action of many different protein and RNA molecules. How biomolecules with shared functions find their way to specific locations has been assumed to occur largely by diffusion-mediated collisions.
Alessandra Dall'Agnese +2 more
exaly +4 more sources