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Biophysics of biomolecular condensates
Biophysical Journal, 2023The formation of biomolecular condensates has emerged as a new biophysical principle for subcellular compartmentalization within cells to facilitate the spatiotemporal regulation of a multitude of complex biomolecular reactions. In this Research Highlight, we summarize the findings that were published in Biophysical Journal during the past two years ...
Ashish, Joshi, Samrat, Mukhopadhyay
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Dissecting the complexity of biomolecular condensates
Biochemical Society Transactions, 2020Biomolecular condensates comprise a diverse and ubiquitous class of membraneless organelles. Condensate assembly is often described by liquid–liquid phase separation. While this process explains many key features, it cannot account for the compositional or architectural complexity that condensates display in cells.
Pinaki Swain, Stephanie C. Weber
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Biomolecular condensates in photosynthesis and metabolism
Current Opinion in Plant Biology, 2020The transient assembly or sequestration of enzymes into clusters permits the channeling of metabolites, but requires spatiotemporal control. Liquid liquid phase separation (LLPS) has recently emerged as a fundamental concept enabling formation of such assemblies into non-membrane bound organelles.
Wunder, Tobias, Mueller-Cajar, Oliver
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Biomolecular condensates in epithelial junctions
Current Opinion in Cell Biology, 2022Epithelial junctions are transmembrane protein complexes that regulate cell adhesion, cell polarity, tissue permeability, and tissue mechanics. Most junctional complexes contain membrane attached cytoplasmic plaques that regulate junction assembly and are composed of multivalent scaffold proteins.
Sun, D. +3 more
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Biomolecular Condensates and Their Links to Cancer Progression
Trends in Biochemical Sciences, 2021Liquid-liquid phase separation (LLPS) has emerged in recent years as an important physicochemical process for organizing diverse processes within cells via the formation of membraneless organelles termed biomolecular condensates. Emerging evidence now suggests that the formation and regulation of biomolecular condensates are also intricately linked to ...
Zhe Liu, Danfeng Cai
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Transcription Regulation by Biomolecular Condensates
Nature Reviews Molecular Cell BiologyBiomolecular condensates regulate transcription by dynamically compartmentalizing the transcription machinery. Classic models of transcription regulation focus on the recruitment and regulation of RNA polymerase II by the formation of complexes at the 1-10 nm length scale, which are driven by structured and stoichiometric interactions.
Pilong LI +2 more
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Biomolecular condensates in membrane receptor signaling
Current Opinion in Cell Biology, 2021Clustering is a prominent feature of receptors at the plasma membrane (PM). It plays an important role in signaling. Liquid-liquid phase separation (LLPS) of proteins is emerging as a novel mechanism underlying the observed clustering. Receptors/transmembrane signaling proteins can be core components essential for LLPS (such as LAT or nephrin) or ...
Khuloud Jaqaman, Jonathon A. Ditlev
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Biomolecular condensates—Prerequisites for anhydrobiosis?
Protein ScienceAbstractIt is often underappreciated that despite water being a requirement for life on Earth, organisms belonging to all taxonomic kingdoms have developed mechanisms to survive desiccation. These organisms, referred to as anhydrobiotes, accumulate specific biomolecules during or before drying that facilitate the survival of desiccation stress ...
Charles A. Elder +9 more
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Biomolecular condensates and disease pathogenesis
Science China Life SciencesBiomolecular condensates or membraneless organelles (MLOs) formed by liquid-liquid phase separation (LLPS) divide intracellular spaces into discrete compartments for specific functions. Dysregulation of LLPS or aberrant phase transition that disturbs the formation or material states of MLOs is closely correlated with neurodegeneration, tumorigenesis ...
Ke, Ruan +13 more
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Peptide diffusion in biomolecular condensates
Biophysical JournalDiffusion determines the turnover of biomolecules in liquid-liquid phase-separated condensates. We considered the mean square displacement and thus the diffusion constant for simple model systems of peptides GGGGG, GGQGG, and GGVGG in aqueous solutions after phase separation by simulating atomic-level models.
Riley J. Workman +3 more
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