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Archives of Biochemistry and Biophysics, 2021
Many intrinsically disordered proteins contain Gly-rich regions which are generally assumed to be disordered. Such regions often form biomolecular condensates which play essential roles in organizing cellular processes.
M. Mompeán +9 more
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Many intrinsically disordered proteins contain Gly-rich regions which are generally assumed to be disordered. Such regions often form biomolecular condensates which play essential roles in organizing cellular processes.
M. Mompeán +9 more
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Capillary forces generated by biomolecular condensates
Nature, 2022Liquid-liquid phase separation and related phase transitions have emerged as generic mechanisms in living cells for the formation of membraneless compartments or biomolecular condensates. The surface between two immiscible phases has an interfacial tension, generating capillary forces that can perform work on the surrounding environment.
Bernardo Gouveia +5 more
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Biomolecular condensates in membrane receptor signaling
Current Opinion in Cell Biology, 2021Clustering is a prominent feature of receptors at the plasma membrane (PM). It plays an important role in signaling. Liquid-liquid phase separation (LLPS) of proteins is emerging as a novel mechanism underlying the observed clustering. Receptors/transmembrane signaling proteins can be core components essential for LLPS (such as LAT or nephrin) or ...
Khuloud Jaqaman, Jonathon A. Ditlev
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Phase behaviour and structure of a model biomolecular condensate.
Soft Matter, 2020Phase separation of immiscible fluids is a common phenomenon in polymer chemistry, and is recognized as an important mechanism by which cells compartmentalize their biochemical reactions.
J. Shillcock +3 more
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Biomolecular condensates and disease pathogenesis
Science China Life SciencesBiomolecular condensates or membraneless organelles (MLOs) formed by liquid-liquid phase separation (LLPS) divide intracellular spaces into discrete compartments for specific functions. Dysregulation of LLPS or aberrant phase transition that disturbs the formation or material states of MLOs is closely correlated with neurodegeneration, tumorigenesis ...
Ke, Ruan +13 more
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Peptide diffusion in biomolecular condensates
Biophysical JournalDiffusion determines the turnover of biomolecules in liquid-liquid phase-separated condensates. We considered the mean square displacement and thus the diffusion constant for simple model systems of peptides GGGGG, GGQGG, and GGVGG in aqueous solutions after phase separation by simulating atomic-level models.
Riley J. Workman +3 more
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Mechanical Remodeling of Nuclear Biomolecular Condensates
PhysiologyOrganism health relies on cell proliferation, migration, and differentiation. These universal processes depend on cytoplasmic reorganization driven notably by the cytoskeleton and its force-generating motors. Their activity generates forces that mechanically agitate the cell nucleus and its interior.
Giulia Soggia +3 more
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A viral biomolecular condensate coordinates assembly of progeny particles
Nature, 2023Matthew Charman +9 more
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Molecular and environmental determinants of biomolecular condensate formation
Nature Chemical Biology, 2022J. A. Villegas +2 more
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Proceedings of the National Academy of Sciences of the United States of America
Significance Biomolecular condensates are essential for spatially organizing cellular reactions in bacteria and eukaryotic cells. Nevertheless, their mechanism remains poorly understood. Using cryoelectron tomography, we focused on the PomXYZ system that
Peng Xu +8 more
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Significance Biomolecular condensates are essential for spatially organizing cellular reactions in bacteria and eukaryotic cells. Nevertheless, their mechanism remains poorly understood. Using cryoelectron tomography, we focused on the PomXYZ system that
Peng Xu +8 more
semanticscholar +1 more source