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Current practices in the study of biomolecular condensates: a community comment
Nature CommunicationsThe realization that the cell is abundantly compartmentalized into biomolecular condensates has opened new opportunities for understanding the physics and chemistry underlying many cellular processes1, fundamentally changing the study of biology2.
Simon Alberti +33 more
semanticscholar +1 more source
Biomolecular condensates in immune cell fate
Nature Reviews ImmunologyFate decisions during immune cell development require temporally precise changes in gene expression. Evidence suggests that the dynamic modulation of these changes is associated with the formation of diverse, membrane-less nucleoprotein assemblies that are termed biomolecular condensates.
Srikanth Kodali +4 more
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Biomolecular Condensates as Novel Antiviral Targets
Journal of Molecular BiologyViral infections pose a significant health risk worldwide. There is a pressing need for more effective antiviral drugs to combat emerging novel viruses and the reemergence of previously controlled viruses. Biomolecular condensates are crucial for viral replication and are promising targets for novel antiviral therapies.
Erik W. Martin +4 more
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Probing condensate microenvironments with a micropeptide killswitch
NatureBiomolecular condensates are thought to create subcellular microenvironments that have different physicochemical properties compared with their surrounding nucleoplasm or cytoplasm1, 2, 3, 4–5.
Yaotian Zhang +22 more
semanticscholar +1 more source
Selective Ion Binding and Uptake Shape the Microenvironment of Biomolecular Condensates
Journal of the American Chemical SocietyBiomolecular condensates modulate various ion-dependent cellular processes and can regulate subcellular ion distributions by selective uptake of ions. To understand these processes, it is essential to uncover the molecular grammar governing condensate ...
Iris B. A. Smokers +8 more
semanticscholar +1 more source
A label-free method for measuring the composition of multicomponent biomolecular condensates
Nature ChemistryMany subcellular compartments are biomolecular condensates made of multiple components, often including several distinct proteins and nucleic acids. However, current tools to measure condensate composition are limited and cannot capture this complexity ...
Patrick M McCall +8 more
semanticscholar +1 more source
Biomolecular condensates sustain pH gradients at equilibrium through charge neutralization
bioRxivElectrochemical gradients are essential to the functioning of cells and form across membranes using active transporters. Here, we show in contrast that condensed biomolecular systems sustain significant pH gradients without any external energy input.
Hannes Ausserwoeger +18 more
semanticscholar +1 more source