Biotechnology and Bioengineering, EarlyView.ABSTRACT Adeno‐associated viral (AAV) vectors for gene therapy are becoming integral to modern medicine, providing therapeutic options for diseases once deemed incurable. Currently, viral vector purification is a critical bottleneck in the gene therapy industry, impacting product efficacy and safety as well as accessibility and cost to patients ...
Kelvin P. Idanwekhai +9 more
wiley +1 more source
Prompting Fab Yeast Surface Display Efficiency by ER Retention and Molecular Chaperon Co-expression. [PDF]
, 2019 For antibody discovery and engineering, yeast surface display (YSD) of antigen-binding fragments (Fabs) and coupled fluorescence activated cell sorting (FACS) provide intact paratopic conformations and quantitative analysis at the monoclonal level, and ...
Ge, Xin +7 more
core
Enhanced Patient-Centricity: How the Biopharmaceutical Industry Is Optimizing Patient Care through AI/ML/DL [PDF]
, 2022 Kelly H. Zou, Jim Z. Li
openalex +1 more source
BMEMat, EarlyView.Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...
Yang Xu +9 more
wiley +1 more source
Strange Bedfellows: Native American Tribes, Big Pharma, and the Legitimacy of Their Alliance [PDF]
, 2006 Lost in the cacophony surrounding the debate about high drug prices is the fundamental principle that pharmaceutical innovation will not occur without the prospect of outsized returns enabled through market exclusivity.
Chenine, Moustafa +2 more
core +1 more source
Machine-learning for biopharmaceutical batch process monitoring with limited data
, 2018 Aditya Tulsyan +2 more
openalex +1 more source
STEM Education and Industry Workforce Life-Long Training Platform Development to Faciliate Smart Biopharmaceutical Manufacturing 4.4 [PDF]
, 2021 Hua Zheng
openalex +1 more source
Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine
BMEMat, EarlyView.Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo +9 more
wiley +1 more source
Practical considerations for optimal designs in clinical dose finding studies [PDF]
Determining an adequate dose level for a drug and, more broadly, characterizing its dose response relationship, are key objectives in the clinical development of any medicinal drug. If the dose is set too high, safety and tolerability problems are likely
Bretz, Frank +2 more
core
Microtopography enhances intestinal drug absorption via Piezo1‐mediated tight junction modulation
BMEMat, EarlyView.Microtopography‐driven enhancement of oral peptide drug delivery by activating Piezo1 channels significantly improves paracellular permeability and bioavailability, offering a novel approach for optimizing macromolecule absorption in pharmaceutical formulations.
Yu Hu +12 more
wiley +1 more source