Results 181 to 190 of about 70,680 (286)

Mixed‐mode membrane chromatography: mechanistic‐modeling‐based optimization and scale‐up of antibody charge variant separation using a novel membrane adsorber

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Efficient manufacturing of complex biopharmaceuticals increasingly relies on innovative downstream processing strategies. Membrane chromatography offers a promising alternative to resin‐based systems by enabling high‐throughput separations at elevated flow rates. Typically used in flow‐through mode, its industrial applications range
Jan Hedrich, Rita Steigmiller, Viktor Simaev, Romas Skudas, Michael Schulte, Mathias Hafner, Christian Frech   +6 more
wiley   +1 more source

Human and financial consequences of herding in oncology drug development: clinical trials of TIGIT inhibitors. [PDF]

BMJ Oncol
Zhang ES, Osipenko L, Hickman JA.
europepmc   +1 more source

Development of a step‐gradient simulated moving bed process for the polishing of monoclonal antibodies with anion exchange chromatography

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND In recent years, biopharmaceutical applications in medicine have seen explosive growth and the need for efficient, rapid and inexpensive purification of these targets is the topic of tremendous research and development. The need to improve process efficiency has been an active area of investigation due to the tremendous potential ...
Yasmina MJ Harsy, Jonas Wege, Anthony Grabski, Romain Dabre, Egbert Müller, Carsten‐René Arlt   +5 more
wiley   +1 more source

Trends in Venture Capital Investment in AI-Driven Biopharmaceutical Startups.

J Med Internet Res
Bazaz A, Ji Y, Socal MP, Kang SY.
europepmc   +1 more source

Research and development financing models for new biopharmaceuticals in the United States. [PDF]

Health Aff Sch
Kang SY, Lee B, Gupta R, Ballreich J, Anderson G.   +4 more
europepmc   +1 more source

Quantitative Real‐Time MRI for the Assessment of Gastric Motility

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Current reference standards for measuring gastric emptying and motility are not considered optimal due to the time required, ionizing radiation, invasiveness, and spatial resolution. Purpose To assess gastric motility using novel real‐time dynamic magnetic resonance imaging in combination with static measurements for gastric ...
Lydia Neubauer, Leonie Forstreuter, Fabian Winter, Fiona Mankertz, Mark O. Wielpütz, Donata S. Grajecki, Antje Steveling, Ali A. Aghdassi, Sebastian Zeißig, Matthew D. Blackledge, Dirk Voit, Jens Frahm, Susanne Schnell, Werner Weitschies, Linus Großmann   +14 more
wiley   +1 more source

Edible mushrooms as emerging biofactories for natural therapeutics and oral biopharmaceutical delivery. [PDF]

Front Fungal Biol
Wang K, Wang A, Meade B.
europepmc   +1 more source

Effect of MPATH‐Dx 2.0 on Diagnostic Agreement in the Histopathologic Assessment of Melanocytic Skin Lesions

JEADV Clinical Practice, EarlyView.
To estimate between pathologist agreement using MPATH‐Dx V1.0 and MPATH‐Dx V2.0 a cross‐sectional reading study on four dermatopathologists assessing paired clinical and histopathology images of melanocytic lesions in blinded and unblinded settings was performed.
Belinda Lai, Lin Zhu, Peter M. Ferguson, Blake O'Brien, Tristan Dodds, Gerardo Ferrara, H. Peter Soyer, Richard A. Scolyer, Katy J. L. Bell   +8 more
wiley   +1 more source

A Call To Action: Developing an Agile Global Regulatory Affairs Workforce for the Future. [PDF]

Ther Innov Regul Sci
AlJuburi L, Mahoney N, Reilly E, Bertha A, Isom DC, Bisordi F, Beakes-Read V, Garvin M, Boyce D, Carl K, Curtis SP, Dudinak J, Garner CO, Latif N, Luik S, Rohrer M, Rupalla K, Taisey M, Votzmeyer R, Wegner M, Williams K.   +20 more
europepmc   +1 more source

Tautomerization Kinetics of Thiouracils at Low Temperatures Driven Solely by Quantum‐Mechanical Tunnelling: Predictions of Suitable Candidates for Future Experiments

International Journal of Chemical Kinetics, EarlyView.
ABSTRACT In the past two decades numerous experiments have been conducted on the kinetics of reactions occurring at low temperatures on inert matrices. In particular, unimolecular proton‐transfer photo‐reactions of compounds containing a carbon–sulfur double bond, or thione group C═S, can lead to the formation of higher energy isomers or tautomers with
Judith Wurmel, John M. Simmie
wiley   +1 more source