Results 31 to 40 of about 23,130 (165)

Biologics and biosimilars in musculoskeletal diseases: addressing regulatory inconsistencies and clinical uncertainty [PDF]

Exploration of Musculoskeletal Diseases
Biologics are complex protein-based medications derived from living organisms, used primarily to treat immune-related diseases. Unlike small-molecule drugs synthesized from chemicals, biologics are produced using advanced biotechnology, making their ...
Lauren N. McGrath, David Moodie, Steven R. Feldman   +2 more
doaj   +1 more source

Preclinical Long-Term Stability and Forced Degradation Assessment of EPICERTIN, a Mucosal Healing Biotherapeutic for Inflammatory Bowel Disease

Pharmaceutics
Background/Objectives: EPICERTIN, a biotherapeutic candidate for mucosal healing in inflammatory bowel disease (IBD) and other mucosal disorders, was subjected to an extensive long-term stability program to evaluate its molecular stability and ...
Wendy M. Kittle, Micaela A. Reeves, Ashley E. Fulkerson, Krystal T. Hamorsky, David A. Morris, Kathleen T. Kitterman, Michael L. Merchant, Nobuyuki Matoba   +7 more
doaj   +1 more source

Systematic review and data-driven insights into CHO cell engineering for next-generation antibody production

mAbs
Chinese hamster ovary (CHO) cells remain the dominant platform for therapeutic antibody and biopharmaceutical production, yet productivity bottlenecks persist, particularly for complex molecules.
Alexandra Schulz, Trent Munro, Anja Puklowski, Emma Slack, Anne B. Tolstrup, Kerstin Otte   +5 more
doaj   +1 more source

Exploring the mucoadhesive behavior of sucrose acetate isobutyrate: a novel excipient for oral delivery of biopharmaceuticals

Drug Delivery, 2019
Oral drug delivery is an attractive noninvasive alternative to injectables. However, oral delivery of biopharmaceuticals is highly challenging due to low stability during transit in the gastrointestinal tract (GIT), resulting in low systemic ...
Stine Harloff-Helleberg, Lies A. L. Fliervoet, Mathias Fanø, Mechthild Schmitt, Maxim Antopolski, Arto Urtti, Hanne Mørck Nielsen   +6 more
doaj   +1 more source

Patient-reported symptoms and burden of eosinophilic esophagitis: evidence from real-world clinical practice

BMC Gastroenterology
Background Eosinophilic esophagitis is a chronic inflammatory disorder of the esophagus. This real-world study used patient and physician surveys to describe the clinical characteristics and disease burden of eosinophilic esophagitis—overall and in a ...
Xiao Xu, Justin Kwiatek, James Siddall, Eduardo Genofre, Heide Stirnadel-Farrant, Rohit Katial   +5 more
doaj   +1 more source

Automated method for quantification of 20 amino acids in cell culture media during biopharmaceutical development

BioTechniques
Herein, a step-by-step protocol for simultaneous detection of 20 amino acids commonly present in cell culture media is described. The protocol facilitates detection of both primary and secondary amino acids through a two-step precolumn derivatization ...
Ankita Dubey, Srishti Joshi, Kratika Upadhyay, Ansuman Mahato, Anurag S Rathore   +4 more
doaj   +1 more source

Plant Molecular Farming – Integration and Exploitation of Side Streams to Achieve Sustainable Biomanufacturing

Frontiers in Plant Science, 2019
Plants have unique advantages over other systems such as mammalian cells for the production of valuable small molecules and proteins. The benefits cited most often include safety due to the absence of replicating human pathogens, simplicity because ...
Johannes F. Buyel, Johannes F. Buyel
doaj   +1 more source

Antimicrobial Peptides As Biologic and Immunotherapeutic Agents against Cancer: A Comprehensive Overview

Frontiers in Immunology, 2017
Antimicrobial peptides (AMPs) are a pervasive and evolutionarily ancient component of innate host defense which is present in virtually all classes of life.
Raheleh Roudi, Nicholas L. Syn, Nicholas L. Syn, Maryam Roudbary   +3 more
doaj   +1 more source

Towards a cleaner CHO chassis: systematic knockout of host cell proteins for efficient biopharmaceutical manufacturing

Frontiers in Bioengineering and Biotechnology
Host cell proteins (HCPs) are major process‐related impurities in biopharmaceutical manufacturing, imposing metabolic burden on production hosts and complicating downstream purification, thereby impacting cost, product stability, and patient safety. Here,
Jannis Peter Marzluf, Jannis Peter Marzluf, Jennifer Klein, Daniela Kirchmeier, Alexander Stärk, Daniel Ziegner, Markus Gehrung, Franziska Rauh, Merle Rattay, Christoph Zehe, Ann-Cathrin Leroux   +10 more
doaj   +1 more source

Evolving Paradigms of Recombinant Protein Production in Pharmaceutical Industry: A Rigorous Review

Sci
Many beneficial proteins have limited natural availability, which often restricts their supply and thereby reduces their potential for therapeutic or industrial usage.
Achuth Jayakrishnan, Wan Rosalina Wan Rosli, Ahmad Rashidi Mohd Tahir, Fashli Syafiq Abd Razak, Phei Er Kee, Hui Suan Ng, Yik-Ling Chew, Siew-Keah Lee, Mahenthiran Ramasamy, Ching Siang Tan, Kai Bin Liew   +10 more
doaj   +1 more source