Results 21 to 30 of about 23,130 (165)

Versatile delivery platform for nucleic acids, negatively charged protein drugs, and genome-editing ribonucleoproteins using a multi-step transformable polyrotaxane

Materials Today Bio, 2023
Various biopharmaceuticals, such as nucleic acids, proteins, and genome-editing molecules, have been developed. Generally, carriers are prepared for each biopharmaceutical to deliver it intracellularly; thus, the applications of individual carriers are ...
Toru Taharabaru, Takuya Kihara, Risako Onodera, Tetsuya Kogo, Yuting Wen, Jun Li, Keiichi Motoyama, Taishi Higashi   +7 more
doaj   +1 more source

Forced Degradation Testing as Complementary Tool for Biosimilarity Assessment

Bioengineering, 2019
Oxidation of monoclonal antibodies (mAbs) can impact their efficacy and may therefore represent critical quality attributes (CQA) that require evaluation.
Yan Felix Karl Dyck, Daniel Rehm, Jan Felix Joseph, Karsten Winkler, Volker Sandig, Wolfgang Jabs, Maria Kristina Parr   +6 more
doaj   +1 more source

Protein N-glycosylation in eukaryotic microalgae and its impact on the production of nuclear expressed biopharmaceuticals

Frontiers in Plant Science, 2014
Microalgae are currently used for the production of food compounds. Recently, few microalgae species have been investigated as potential biofactories for the production of biopharmaceuticals.
Elodie eMathieu-Rivet, Marie-Christine eKiefer-Meyer, Gaetan eVanier, Clement eOvide, Carole eBurel, Patrice eLEROUGE, Muriel eBardor   +6 more
doaj   +1 more source

Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics Development

Pathogens, 2020
Novel Coronavirus (2019-nCoV) is an emerging pathogen that was first identified in Wuhan, China in late December 2019. This virus is responsible for the ongoing outbreak that causes severe respiratory illness and pneumonia-like infection in humans.
Balamurugan Shanmugaraj, Ashwini Malla, Waranyoo Phoolcharoen   +2 more
doaj   +1 more source

SIRPα-Fc fusion protein IMM01 exhibits dual anti-tumor activities by targeting CD47/SIRPα signal pathway via blocking the “don’t eat me” signal and activating the “eat me” signal

Journal of Hematology & Oncology, 2022
A novel recombinant SIRPα-Fc fusion protein, IMM01, was constructed and produced using an in-house developed CHO-K1 cell expression system, and the anti-tumor mechanism of IMM01 targeting the CD47-SIRPα pathway was explored. The phagocytosis and in vitro
Jifeng Yu, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang, Wei Zhang, Li Zhang, Gui Zhao, Xiaoping Tu, Liang Peng, Sijin Liu, Xing Bai, Yongping Song, Zhongxing Jiang, Ruliang Zhang, Wenzhi Tian   +16 more
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Clinical Immunogenicity Evaluation of Eptinezumab, a Therapeutic Humanized Monoclonal Antibody Targeting Calcitonin Gene-Related Peptide (CGRP) for the Preventive Treatment of Migraine

Frontiers in Immunology, 2021
BackgroundEptinezumab is a humanized monoclonal antibody that selectively binds calcitonin gene-related peptide and is indicated for the preventive treatment of migraine in adults.
Susan Pederson, David M. Biondi, Brent Allan, Roger Cady, Barbara Schaeffler, Brian Baker, John Latham   +6 more
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Open-Ended, Metacognitive Conception of Classes for the Advancement of Nonconformity and Creative Thought

Open Education Studies, 2020
Instructional methods incorporating metacognitive or open-ended elements have been gaining popularity, but synergies between the two have rarely been explored.
Uskoković Vuk
doaj   +1 more source

Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing

Nature Communications, 2023
Genome editing, specifically CRISPR/Cas9 technology, has revolutionized biomedical research and offers potential cures for genetic diseases. Despite rapid progress, low efficiency of targeted DNA integration and generation of unintended mutations ...
Sandra Wimberger, Nina Akrap, Mike Firth, Johan Brengdahl, Susanna Engberg, Marie K. Schwinn, Michael R. Slater, Anders Lundin, Pei-Pei Hsieh, Songyuan Li, Silvia Cerboni, Jonathan Sumner, Burcu Bestas, Bastian Schiffthaler, Björn Magnusson, Silvio Di Castro, Preeti Iyer, Mohammad Bohlooly-Y, Thomas Machleidt, Steve Rees, Ola Engkvist, Tyrell Norris, Elaine B. Cadogan, Josep V. Forment, Saša Šviković, Pinar Akcakaya, Amir Taheri-Ghahfarokhi, Marcello Maresca   +27 more
doaj   +1 more source

Effects of pentosan polysulfate sodium on synovial fluid biomarkers in moderate to severe knee osteoarthritis: an exploratory, phase 2, randomized, double-blind, placebo-controlled trial

Arthritis Research & Therapy
Background To evaluate synovial fluid biomarkers of cartilage degradation, inflammation, and pain in participants with knee osteoarthritis pain treated with subcutaneous injectable pentosan polysulfate sodium (iPPS).
Donna L. Skerrett, Catherine J. M. Stapledon, Mukesh Ahuja, Divya R. Navuru, Melanie J. Duiker, Ravi Krishnan, Thomas J. Schnitzer, Rachel A. Peat, Philip D. Bloom   +8 more
doaj   +1 more source

Extracellular Vesicles as Precision Delivery Systems for Biopharmaceuticals: Innovations, Challenges, and Therapeutic Potential

Pharmaceutics
Unlike traditional small-molecule agents, biopharmaceuticals, like synthetic RNAs, enzymes, and monoclonal antibodies, are highly vulnerable to environmental conditions.
Sidhesh Mohak, Zsolt Fabian
doaj   +1 more source