Results 161 to 170 of about 17,488 (290)

Microbial influences on immune modulation and colorectal cancer progression through combined transcriptomic and microbiomic analysis

iMetaOmics, EarlyView.
Schematic representation of the distinct tumor microenvironment characteristics in CA1 and CA2 subtypes. CA1 illustrates an immune‐active tumor microenvironment characterized by elevated infiltration of immune cells, particularly CD8 + T cells and macrophages, and enhanced IFN‐γ signaling.
Shuting Xia, Likun Wang, Yangzhuo Xu, Jiaqi Zhang, Zeyang Zhou, Libing Sun, Heng Li, Chungen Xing, Jialu Mao, Yina Liu, Fulin Yang, Ling Zhong, Jiancheng Xu, Xiaodong Yang, Zhemin Zhou   +14 more
wiley   +1 more source

Association of <i>FADS2</i> polymorphism rs174538 with fatty acid metabolism and disease severity in Japanese patients with Crohn's disease. [PDF]

World J Gastroenterol
Matsuzawa H, Ito Z, Uchiyama K, Motoi Y, Ohtaki Y, Iwashita Y, Suzuki S, Nakada T, Koido S, Kojima K, Murohashi K, Saruta M, Ohkusa T, Kubota T.   +13 more
europepmc   +1 more source

The Role of Pre-IPO Financial Indicators and Intermediaries in Aftermarket Performance and Survival in the US Biopharmaceutical Market [PDF]

, 2012
David R. Williams, Carlton C. Young
openalex   +1 more source

Minor Contribution of UGT1A1 Inhibition to Atazanavir‐Related Bilirubin Elevation Supported by Conservative PBPK Modeling and Clinical Data

Clinical Pharmacology &Therapeutics, EarlyView.
Jin Dong, Pradeep Sharma, Rasha Emara, Derek Cheung, Weifeng Tang, Diansong Zhou, David W. Boulton, Mats Någård, Miki S. Park   +8 more
wiley   +1 more source

Using generalized quantitative structure–property relationship (QSPR) models to predict host cell protein retention in ion‐exchange chromatography

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Selecting an optimal chromatography resin during biopharmaceutical downstream process development is a great challenge. This is especially the case for recombinant subunit vaccines, where product properties vary greatly and recovery often involves cell lysis, which yields a complex mixture of different host cell materials. Host cell
Tim Neijenhuis, Olivier Le Bussy, Geoffroy Geldhof, Marieke E Klijn, Marcel Ottens   +4 more
wiley   +1 more source

Expression of concern: Flavin-adenine-dinucleotide gold complex nanoparticles: chemical modeling design, physico-chemical assessment and perspectives in nanomedicine. [PDF]

Nanoscale Adv
Arib C, Bouchemal N, Barile M, Paleni D, Djaker N, Dupont N, Spadavecchia J.   +6 more
europepmc   +1 more source

Color Flow Imaging Microscopy Improves Identification of Stress Sources of Protein Aggregates in Biopharmaceuticals [PDF]

Michaela Cohrs, Shiwoo Koak, Yejin Lee, Yu Sub Sung, Wesley De Neve, Hristo L. Svilenov, Utku Özbulak   +6 more
openalex   +1 more source

Exometabolome analysis reveals hypoxia at the up-scaling of a Saccharomyces cerevisiae high-cell density fed-batch biopharmaceutical process [PDF]

, 2014
Zhibiao Fu, Thomas D Verderame, Julie Leighton, Brante P. Sampey, Edward R. Appelbaum, Pramatesh S. Patel, Juan C. Aon   +6 more
openalex   +1 more source

Optimizing rapeseed protein purification: a continuous chromatographic approach for napin and cruciferin

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Napin and cruciferin, the predominant storage proteins in Brassica napus (rapeseed), exhibit favorable techno‐functional properties such as emulsification and gel formation, positioning them as promising candidates for the encapsulation and delivery of bioactive compounds. Their classification as GRAS (Generally Recognized As Safe),
Jonas Arnecke, Jessica Gillmann, Tim Börner, Mathias Hafner, Christian Frech   +4 more
wiley   +1 more source

Spatial Segregation Within Dissolving Microneedle Patches Overcomes Antigenic Interference and Enables Potent Bivalent Influenza-RSV Vaccination in Mice. [PDF]

Vaccines (Basel)
Fan F, Wu Y, Lin H, Zhang X, Wang L, He Y, Zhang S, Zhang M, Zhao G, Xiang R, Kang Y, Chen M, Li Z, Guo YB, Zhou H, Zhao C, Wang MC, Gu JY, Wang B, Gao XM.   +19 more
europepmc   +1 more source