Results 181 to 190 of about 15,283 (290)

Model-Integrated Bioequivalence (MIBE) in Generic Drug Research: Can We Ease the Bioequivalence Burden? [PDF]

Pharmaceutics
Kollipara S, Boddu R, Uppuluri CT, Saini AK.   +3 more
europepmc   +1 more source

The Effect of LRRK2 and GBA1 Mutations on Survival in Early‐ and Late‐Onset Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Mutations in the glucocerebrosidase 1 (GBA1) and leucine‐rich repeat kinase 2 (LRRK2) genes are associated with Parkinson's disease (PD) phenotype. Objective To asses the contribution of genetic status to long‐term survival of patients with PD.
Raz Rubin, Roy N. Alcalay, Nurit Omer, Orly Goldstein, Mali Gana Weisz, Anat Mirelman, Avner Thaler   +6 more
wiley   +1 more source

The Effect of Food and the Proton Pump Inhibitor Rabeprazole on Binimetinib Pharmacokinetics in Healthy Participants. [PDF]

Clin Pharmacokinet
Hahn E, Piscitelli J, Huynh D, Chavira R, Wollenberg L, Reddy MB.   +5 more
europepmc   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Virtual bioequivalence-guided PBBM prediction for ibuprofen/diphenhydramine citrate tablets: impact of dissolution variability and clinical standard development. [PDF]

Saudi Pharm J
Wang Z, Cao Z, Guo C, Zhang Q, Zhou R, Chen J, Su F, Liu W, Chu Z, Zheng L, Hu W.   +10 more
europepmc   +1 more source

Modeling of Disease Progression of Type 2 Diabetes Using Real‐World Data: Quantifying Competing Risks of Morbidity and Mortality

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 606-615, March 2025.
ABSTRACT Type 2 diabetes (T2D) is a progressive metabolic disorder that could be an underlying cause of long‐term complications that increase mortality. The assessment of the probability of such events could be essential for mortality risk management. This work aimed to establish a framework for risk predictions of macrovascular complications (MVC) and
Hanna Kunina, Stefan Franzén, Maria C. Kjellsson   +2 more
wiley   +1 more source

Breaking Alzheimer's Disease Barrier: The Role of Xanthoceras sorbifolia Bunge Oil in Gut‐Brain Axis and TLR4/Myd88/MAPK Pathway Inhibition

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with cognitive decline and neuroinflammation. Xanthoceras sorbifolia Bunge oil (XSBO), a woody plant oil rich in bioactive fatty acids, has shown potential health benefits.
Lijing Du, Shikai Yan, Xiaopeng Ren, Syed Shams ul Hassan, Yuanfang Sun, Yu Gan, Xue Xiao, Shasha Li, Huizi Jin   +8 more
wiley   +1 more source

Formalizing method choice: a data-driven selection of mechanistic models for predicting human heart drug partitioning. [PDF]

J Pharmacokinet Pharmacodyn
Ulaszek S, Lisowski B, Jesionek M, Wiśniowska B, Polak S.   +4 more
europepmc   +1 more source

Revisiting industry effects: The assignment of firms to industries

Strategic Management Journal, EarlyView.
Abstract Research Summary Strategy research examines the drivers of firm performance. Variance decomposition studies have analyzed industry's impact, with little attention paid to the industry to which a firm is assigned. This study investigates how industry assignment affects the findings about industry's impact.
Alireza Eshraghi, Bart S. Vanneste
wiley   +1 more source