Results 181 to 190 of about 39,175 (290)

Modelling biopharmaceutical manufacture: Design and implementation of SimBiopharma [PDF]

, 2006
Suzanne S. Farid, John Washbrook, Nigel J. Titchener‐Hooker   +2 more
openalex   +1 more source

Nobiletin Ameliorates Aβ1–42‐Induced Cognitive Disorder and Mitochondrial Dysfunction via Targeting the Key Circadian Regulator Bmal1

Food Safety and Health, EarlyView.
Nobiletin (NOB) ameliorates Aβ‐induced Alzheimer’s pathology by restoring circadian rhythm via Bmal1. NOB rescues cognitive deficits, synaptic damage, and mitochondrial dysfunction in mice and neurons by enhancing Bmal1/Clock oscillations and downstream mitochondrial integrity, positioning circadian regulation as a therapeutic target for Alzheimer's ...
Huajing Gao, Qinglin Qu, Ning Wang, Xue Gao, Peihua Li, Yanquan Mou, Xiangrui Kong, Yannan Chen, Dapeng Li, Xintong Tan   +9 more
wiley   +1 more source

Correction: Wu et al. Synthesis of Novel Lipophilic <i>N</i>-Substituted Norcantharimide Derivatives and Evaluation of Their Anticancer Activities. <i>Molecules</i> 2014, <i>19</i>, 6911-6928. [PDF]

Molecules
Wu JY, Kuo CD, Chu CY, Chen MS, Lin JH, Chen YJ, Liao HF.   +6 more
europepmc   +1 more source

Monitoring patients treated with anti-TNF- biopharmaceuticals: assessing serum infliximab and anti-infliximab antibodies [PDF]

, 2007
Morten Svenson, P. Geborek, Tore Saxne, Klaus Bendtzen   +3 more
openalex   +1 more source

Development of a Physiologically Based Biopharmaceutics Model Report Template: Considerations for Improved Quality in View of Regulatory Submissions. [PDF]

Mol Pharm
Arora S, Pepin X, Jamei M, Sharma P, Heimbach T, Wagner C, Bransford P, Kollipara S, Ahmed T, Hingle M, Dallmann A, Scherholz M, Stamatis SD, Cano-Vega M, Mistry N, Tannergren C, Borges L, Lindahl A, Rullo G, Mackie C, Mitra A, Kushner J, Harish Jain KM, Polli JE.   +23 more
europepmc   +1 more source

The Nonfeminizing Enantiomer of 17β-Estradiol Exerts Protective Effects in Neuronal Cultures and a Rat Model of Cerebral Ischemia**This work was supported by NIH Grants AG-10485 (to J.W.S.) and GM- 47969 (to D.F.C.), U.S. Army Grant DAMD-17–99-1–9473 (to J.W.S.), and Apollo Biopharmaceutics, Inc. funding (to J.W.S. and D.F.C.).

, 2001
Pattie S. Green, Shao-Hua Yang, Kent R. Nilsson, Aman Kumar, Douglas F. Covey, James W. Simpkins   +5 more
openalex   +1 more source

Cross‐continental transmission and host adaptation of Mycobacterium tuberculosis in China unveiled by population history reconstruction and adaptive evolution signal detection

iMetaOmics, EarlyView.
This study showed that four Mycobacterium tuberculosis complex (MTBC) sub‐lineages might be introduced into China 1000–400 years ago via Europe‐China dispersal routes, where they diversified into local clades, and later underwent population expansions that coincided with periods of climatic cooling and warfare.
Wei Wu, Zhuochong Liu, Haiqi Chen, Yuhan Tang, Zhonghua Jiang, Yiyang Zhang, Andong Zhang, Zhiwei Zhou, Robert S. Marks, Fan Zhang, Haibing Yuan, Yan Yu, Kangshan Mao, András Dinnyés, Nalin Rastogi, Jianping Xie, Qun Sun   +16 more
wiley   +1 more source

Integrating In Vitro BE Checker with In Silico Physiologically Based Biopharmaceutics Modeling to Predict the Pharmacokinetic Profiles of Oral Drug Products. [PDF]

Pharmaceutics
Niino T, Masada T, Takagi T, Kataoka M, Yoshida H, Yamashita S, Kambayashi A.   +6 more
europepmc   +1 more source

The European Clinical Trials Directive: What does this mean for the biopharmaceutical industry?

, 2001
Simon Bryson
openalex   +1 more source

CultiFlask 50: a versatile tool for media optimization in biopharmaceutical production [PDF]

, 2007
Joachim Luecke
openalex   +1 more source