Results 71 to 80 of about 39,175 (290)
Efficient delivery of mesenchymal stem/stromal cells to injured liver by surface PEGylation
Stem Cell Research & Therapy, 2023 Background Mesenchymal stem/stromal cells (MSCs) have been used in clinical trials for various diseases. These have certain notable functions such as homing to inflammation sites, tissue repair, and immune regulation.
Yukiya Takayama +5 more
doaj +1 more source
Inhibition of Tumor Lipogenesis and Growth by Peptide‐Based Targeting of SREBP Activation
Advanced Science, EarlyView.A peptide that replicates the amino acid sequence in Insig1/2 loop 1 inhibits the IGF1‐induced interaction between PCK1 and Insig1/2, PCK1‐mediated phosphorylation of Insig1/2, and SREBP activity‐dependent lipid synthesis. Administration of the LNP‐Insig1/2 loop 1 peptide effectively attenuates tumor growth and sensitizes tumors to the antitumor effect
Shudi Luo +10 more
wiley +1 more source
Reduced Pressure Ionization Enhances Native Mass Spectrometry of Proteins and Protein Complexes
Angewandte Chemie, EarlyView.Reduced pressure for electrospray ionization of native proteins narrows peak widths and increases signal. This straightforward add‐on to existing native MS platforms improves performance in challenging buffers and enables detection of protein interactions at concentrations as low as 50 nM, without significantly disrupting structure as confirmed by ...
Jake P. Violi +2 more
wiley +2 more sources
Enhancer Reprogramming Reveals the Tumorigenic Role of PTPRZ1 in Lung Squamous Cell Carcinoma
Advanced Science, EarlyView.Lung squamous cell cancer (LUSC) is deadly due to lack of good treatments. Here, multiomics techniques are applied to LUSC tumors and find thousands of cancer‐specific enhancers controlling key genes. Interestingly, the gene PTPRZ1 is identified as a critical oncogene driven by the LUSC‐acquired enhancers. PTPRZ1 is activated by MDK, fueling cancer via
Yong‐Qiang Ning +11 more
wiley +1 more source
Drug absorption through a cell monolayer: a theoretical work on a non-linear three-compartment model [PDF]
, 2009 The subject of analysis is a non-linear three-compartment model, widely used in pharmacological absorption studies. It has been transformed into a general form, thus leading automatically to an appropriate approximation.
Acharya +31 more
core +2 more sources
Nitrosylated high density lipoprotein is recognized by a scavenger receptor in rat liver.
Journal of Lipid Research, 1989 In order to assess the presence of specific recognition sites for high density lipoprotein (HDL) in vivo, HDL was nitrosylated with tetranitromethane and the decay and liver uptake were compared with that of native HDL.
M F Kleinherenbrink-Stins +5 more
doaj +1 more source
Advanced Science, EarlyView.In this study, ASH2L‐K312‐lac is identified as a critical driver that promotes the malignant progression of hepatocellular carcinoma (HCC). Furthermore, through a comprehensive series of cell biological and molecular biological experiments, integrated with diverse animal models and systematic application of high‐throughput sequencing technologies, it ...
Hexu Han +14 more
wiley +1 more source
Glucosamine HCl-based solid dispersions to enhance the biopharmaceutical properties of acyclovir [PDF]
, 2019 The objective of the work presented here was to assess the feasibility of using glucosamine HCl as a solid-dispersion (SD) carrier to enhance the biopharmaceutical properties of a BCS class III/IV drug, acyclovir (ACV). The solid-dispersions of acyclovir
Bhagat, Snehal B. +6 more
core +1 more source
Advanced Science, EarlyView.In this work, bionic dual receptor (BDR) e‐skin based on the iontronic and triboelectric effects is proposed, inspired by the slow‐adapting and fast‐adapting receptors. Motivated by intelligent software algorithms and high‐speed hardware circuits, the proposed intelligent autonomous material cognition system integrated with the EDB e‐skin can ...
Hao Li +5 more
wiley +1 more source