Results 131 to 140 of about 1,130,252 (283)

Tau Pathology in Alzheimer's Disease Uniquely Affects Sulcal Depths

Annals of Neurology, EarlyView.
Objective Though it is widely known that tau deposition affects brain structure, the precise localization of these effects is poorly understood, especially in relation to gyral and sulcal anatomy. We investigated whether tau pathology in Alzheimer's disease (AD) preferentially affects sulci, and particularly sulcal depths.
Samira A. Maboudian, Corrina S. Fonseca, Adam C. Martersteck, Yishu Chao, Yuheng Chen, Daniela Ushizima, Duygu Tosun, Lea T. Grinberg, Kevin S. Weiner, William J. Jagust, for the Alzheimer's Disease Neuroimaging Initiative   +10 more
wiley   +1 more source

Deciphering the mitigating role of silicon on tomato seedlings under lambda cyhalothrin and difenoconazole coexposure

Scientific Reports
The multiple contamination of pesticides are common in farmland soil. However, there is a noteworthy knowledge gap regarding the ecophysiological response of co-exposure of pesticides on non-target crops under such conditions.
Nabil Touzout, Adil Mihoub, Iftikhar Ahmad, Sabrina Lekmine, Hichem Tahraoui, Feriel Krache, Ehsan Ali, Sarfraz Hussain, Subhan Danish, Abdeltif Amrane, Hossam S. El-Beltagi, Nazih Y. Rebouh   +11 more
doaj   +1 more source

2SBP-02 Intentional creation of crystal-contact free space for monitoring large amplitude motions of ligands in protein crystals(2SBP Transient macromolecular complexes involved in multilevel biological phenomena,Symposium,The 51th Annual Meeting of the Biophysical Society of Japan)

, 2013
Daisuke Kohda
openalex   +2 more sources

Bioprinted Excitable Tissues with Multistimulation Systems for Promoting Function and Maturation

Advanced NanoBiomed Research, EarlyView.
This review provides an overview of stimulation strategies used to enhance the functional maturation of bioprinted excitable tissues. It addresses key limitations in physiological performance of bioprinted excitable tissues, outlines major stimulation modalities—including electrical, mechanical, optical, magnetic, ultrasound, and hybrid—and examines ...
Uijung Yong, Jinseon Park, Jinah Jang
wiley   +1 more source

2SBP-05 Chemokine receptor oligomerization : a potential mechanism for regulating lymphocyte and cancer cell migration(2SBP Transient macromolecular complexes involved in multilevel biological phenomena,Symposium,The 51th Annual Meeting of the Biophysical Society of Japan)

, 2013
Haruko Hayasaka, Daichi Kobayashi, Masayuki Miyasaka   +2 more
openalex   +2 more sources

Surface‐Coated Inorganic Nanomaterials for Drug Delivery: Chemical Design, Biomedical Applications, and Mechanistic Insights

Advanced NanoBiomed Research, EarlyView.
This review explores how surface‐coated inorganic nanomaterials are chemically engineered for advanced drug delivery. It highlights design principles, coating strategies, and biomedical applications, emphasizing how surface chemistry governs biocompatibility, targeting, and controlled release.
Hossein Daneshgar, Sepideh Ahmadi, Nikzad Abbariki, Navid Rabiee, Sidi A. Bencherif   +4 more
wiley   +1 more source

2SBP-04 Chemical protein labeling in living systems for its analysis(2SBP Transient macromolecular complexes involved in multilevel biological phenomena,Symposium,The 51th Annual Meeting of the Biophysical Society of Japan)

, 2013
Itaru Hamachi
openalex   +2 more sources

Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC‐Induced Degradation

Angewandte Chemie International Edition, EarlyView.
Proteolysis‐targeting chimeras (PROTACs) enable degradation of proteins previously considered undruggable by harnessing the cellular ubiquitin–proteasome system. In this study, Schäfer et al. identify thiazole‐based small molecules that allosterically bind the zinc finger domain of ubiquitin‐specific protease 39 (USP39), a non‐enzymatic scaffold ...
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source

The Role of indirect mechanotransduction phenomena in microtrauma development within intervertebral discs – a computational biophysical analysis

, 2018
Comunicació presentada a: IRCOBI Conference 2018, celebrada a Atenes, Grècia, del 12 al 14 de setembre de 2018.
Baumgartner, Laura, González Ballester, Miguel Ángel, 1973-, Noailly, Jérôme   +2 more
openaire   +1 more source

2SBP-03 A gel-encapsulated bioreactor system for NMR studies of protein-protein interactions in living mammalian cells(2SBP Transient macromolecular complexes involved in multilevel biological phenomena,Symposium,The 51th Annual Meeting of the Biophysical Society of Japan)

, 2013
N. Nishida, Ichio Shimada
openalex   +2 more sources