Results 41 to 50 of about 1,142,090 (245)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Comparing parameter-reduction methods on a biophysical model of an auditory hair cell

Physical Review Research
Biophysical models describing complex cellular phenomena typically include systems of nonlinear differential equations with many free parameters. While experimental measurements can fix some parameters, those describing internal cellular processes ...
Joseph M. Marcinik, Martín A. Toderi, Dolores Bozovic   +2 more
doaj   +1 more source

Characterization of Sensory-Motor Behavior Under Cognitive Load Using a New Statistical Platform for Studies of Embodied Cognition

Frontiers in Human Neuroscience, 2018
The field of enacted/embodied cognition has emerged as a contemporary attempt to connect the mind and body in the study of cognition. However, there has been a paucity of methods that enable a multi-layered approach tapping into different levels of ...
Jihye Ryu, Elizabeth B. Torres
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Commentary on "biophysical Economics" and Evolving Areas

, 2016
© 2016 World Scientific Publishing Company.In this Issue, papers in the area of socio-econo-physics and biophysical economics are presented. We have recently introduced socio-econo-physics and biophysical economics in Biophysical Reviews and Letters (BRL)
Coban, GÜL, Adigüzel, Yekbun, Adıgüzel, Yekbun, Flomenbom, Ophir, Çoban, Gül Ünal   +4 more
core   +1 more source

Biophysical Review’s ‘meet the editors series’—a profile of Joshua W. K. Ho

, 2020
It is my pleasure to write a few words to introduce myself to the readers of Biophysical Reviews as part of the ‘meet the editors’ series. [InlineMediaObject not available: see fulltext.] A portrait of Dr. Joshua Ho.
Ho, JWK
core   +1 more source

Characterizing Cellular Biophysical Responses to Stress by Relating Density, Deformability, and Size [PDF]

, 2015
Cellular physical properties are important indicators of specific cell states. Although changes in individual biophysical parameters, such as cell size, density, and deformability, during cellular processes have been investigated in great detail ...
Hecht, Vivian C., Vivian C. Hecht, Sangwon Byun, Hecht, Vivian Chaya, Manalis, Scott R., Scott R. Manalis, Manalis, Scott R, Byun, Sangwon   +7 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Historical and Critical Review on Biophysical Economics

, 2016
Biophysical economics is initiated with the long history of the relation of economics with ecological basis and biophysical perspectives of the physiocrats.
Yekbun Adigüzel, Adıgüzel, Yekbun
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source