Results 31 to 40 of about 260,009 (313)
eLife, 2016 Nuclear Pore Complexes (NPCs) are key cellular transporter that control nucleocytoplasmic transport in eukaryotic cells, but its transport mechanism is still not understood.
Andrei Vovk +7 more
doaj +1 more source
Biophysics of Mechanotransduction [PDF]
European Biophysics Journal, 2015 (Singer and Nicolson 1972). As a physical barrier it presents a major target of mechanical forces stretching, compressing, bending or even breaking it, if an excessive force is acting on it. As a composite of a large variety of lipid molecules such as phospholipids, sphingolipids, cholesterol and many others, the lipid bilayer of the cell membrane ...
Boris Martinac +2 more
openaire +3 more sources
Annual Review of Biophysics, 2022 Biophysics is a way of approaching biological problems through numbers, physical laws, models, and quantitative logic. In a long scientific career, I have seen the formation and fruition of the ion channel concept through biophysical study. Marvelous discoveries were made as our instruments evolved from vacuum tubes to transistors; computers evolved ...
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AIMS Biophysics, 2023 In this paper, a biophysical fractional diffusive cancer model with virotherapy is thoroughly analyzed and analytically simulated. The goal of this biophysical model is to represent both the dynamics of cancer development and the results of virotherapy ...
Mohammed Alabedalhadi +2 more
doaj +1 more source
Journal of Cardiovascular Development and Disease, 2022 Background: Baseline impedance, radiofrequency current, and impedance drop during radiofrequency catheter ablation are thought to predict effective lesion formation.
Ramiro M. Irastorza +6 more
doaj +1 more source
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Viruses, 2020 The management of chronic hepatitis B virus (CHB) infection is an area of massive unmet clinical need worldwide. In spite of the development of powerful nucleoside/nucleotide analogue (NUC) drugs, and the widespread use of immune stimulators such as ...
Ganesh Selvaraj Duraisamy +6 more
doaj +1 more source
Biophysics of protein evolution and evolutionary protein biophysics [PDF]
Journal of The Royal Society Interface, 2014 The study of molecular evolution at the level of protein-coding genes often entails comparing large datasets of sequences to infer their evolutionary relationships. Despite the importance of a protein's structure and conformational dynamics to its function and thus its fitness, common phylogenetic methods embody minimal biophysical knowledge of ...
Tobias Sikosek, Hue Sun Chan
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FEBS Letters, EarlyView.Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke +2 more
wiley +1 more source