Results 31 to 40 of about 472,523 (280)

Simple biophysics underpins collective conformations of the intrinsically disordered proteins of the Nuclear Pore Complex

open access: yeseLife, 2016
Nuclear Pore Complexes (NPCs) are key cellular transporter that control nucleocytoplasmic transport in eukaryotic cells, but its transport mechanism is still not understood.
Andrei Vovk   +7 more
doaj   +1 more source

Communications Biophysics [PDF]

open access: yes, 1974
Contains research objectives and summary of research.National Institutes of Health (Grant 5 PO1 GM14940-07)National Institutes of Health (Grant 1 RO1 NS11000-01)Clarence J.
Braida, Louis D.   +15 more
core   +3 more sources

Investigating the potential for a limited quantum speedup on protein lattice problems

open access: yesNew Journal of Physics, 2021
Protein folding is a central challenge in computational biology, with important applications in molecular biology, drug discovery and catalyst design.
Carlos Outeiral   +5 more
doaj   +1 more source

Stage epicrisis: analysis of innovations of the Pavlov University through the eyes of its graduates

open access: yesУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2022
The article presents a generalized material of the historical establishment of laboratory medicine at the Pavlov First Saint Petersburg State Medical University (University), based on a survey of graduates and employees of the laboratory service of the ...
Yu. V. Emanuel   +3 more
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

open access: yesFEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Differences in cortical contractile properties between healthy epithelial and cancerous mesenchymal breast cells

open access: yesNew Journal of Physics, 2021
Cell contractility is mainly imagined as a force dipole-like interaction based on actin stress fibers that pull on cellular adhesion sites. Here, we present a different type of contractility based on isotropic contractions within the actomyosin cortex ...
Enrico Warmt   +10 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Molecular Dynamics Simulations Reveal Canonical Conformations in Different pMHC/TCR Interactions

open access: yesCells, 2020
The major defense system against microbial pathogens in vertebrates is the adaptive immune response and represents an effective mechanism in cancer surveillance. T cells represent an essential component of this complex system.
Josephine Alba   +4 more
doaj   +1 more source

Edge-effects dominate copying thermodynamics for finite-length molecular oligomers

open access: yesNew Journal of Physics, 2021
A signature feature of living systems is their ability to produce copies of information-carrying molecular templates such as DNA. These copies are made by assembling a set of monomer molecules into a linear macromolecule with a sequence determined by the
Jenny M Poulton, Thomas E Ouldridge
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

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