Results 61 to 70 of about 461,509 (270)

Binding-Induced Conformational Changes Involved in Sliding Clamp PCNA and DNA Polymerase DPO4

iScience, 2020
Summary: Cooperation between DNA polymerases and DNA sliding clamp proteins is essential for DNA replication and repair. However, it is still challenging to clarify the binding mechanism and the movements of Y-family DNA polymerase IV (DPO4) on the ...
Wen-Ting Chu, Zucai Suo, Jin Wang
doaj  

Proteomic Dissection of Nanotopography-Sensitive Mechanotransductive Signaling Hubs that Foster Neuronal Differentiation in PC12 Cells

Frontiers in Cellular Neuroscience, 2018
Neuronal cells are competent in precisely sensing nanotopographical features of their microenvironment. The perceived microenvironmental information will be “interpreted” by mechanotransductive processes and impacts on neuronal functioning and ...
Elisa Maffioli, Carsten Schulte, Carsten Schulte, Simona Nonnis, Simona Nonnis, Francesca Grassi Scalvini, Francesca Grassi Scalvini, Claudio Piazzoni, Cristina Lenardi, Armando Negri, Armando Negri, Paolo Milani, Gabriella Tedeschi, Gabriella Tedeschi   +13 more
doaj   +1 more source

Understanding the Feedback Loops between Energy, Matter and Life

Frontiers in Bioscience-Elite, 2022
This review gathers recent findings in biophysics that shed light on the biological principle of self-organization, spanning from molecules to more complicated systems with higher information processing capacity.
Richard H.W. Funk
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Single trajectory characterization via machine learning

New Journal of Physics, 2020
In order to study transport in complex environments, it is extremely important to determine the physical mechanism underlying diffusion and precisely characterize its nature and parameters.
Gorka Muñoz-Gil, Miguel Angel Garcia-March, Carlo Manzo, José D Martín-Guerrero, Maciej Lewenstein   +4 more
doaj   +1 more source

Current and future perspectives of atomic force microscopy to elicit the intrinsic properties of soft matter at the single molecule level

AIMS Bioengineering, 2022
Soft matter encompasses multitude of systems like biomolecules, living cells, polymers, composites or blends. The increasing interest to better understand their physico-chemical properties has significantly favored the development of new techniques with ...
Carlos Marcuello
doaj   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

To the 120th anniversary of A.L. Chizhevsky’s birth

Solar-Terrestrial Physics, 2016
Alexander Leonidovich Chizhevsky (1897–1964) is the founder of heliobiology. This paper is presented as a scientific essay and is dedicated to the memory of Chizhevsky. We briefly discuss an unusual aspect of heliobiology.
Guglielmi A.V., Ruban V.F.
doaj   +1 more source

Communications Biophysics [PDF]

, 1968
Contains reports on four research projects.National Institutes of Health (Grant 1 P01 GM-14940-01)Joint Services Electronics Programs (U.S. Army, U.S. Navy, and U.S.
Burns, S. K., Demko, P., Jr., Henry, R. W., Pfeiffer, R. R., von Bismarck, G.   +4 more
core  

Implementation of the Combined--Nonlinear Condensation Transformation

, 2002
We discuss several applications of the recently proposed combined nonlinear-condensation transformation (CNCT) for the evaluation of slowly convergent, nonalternating series.
Abe, Abe, Aksenov, Bailey, Bailey, Bailey, Bailey, Bailey, Baratella, Bateman, Blaisdell, Boersma, Bromwich, Champernowne, Daniel, Darwin, Dempsey, Dempsey, Denisov, Doray, Drake, Fisher, Forrey, Gamow, Gautschi, Gerhard Soff, Gnedenko, Good, Haywood, Herdan, Homeier, Jens Becher, Jentschura, Jentschura, Jentschura, Jentschura, Jentschura, Jentschura, Jentschura, Johnson, Karlin, Knopp, Konopka, Kulasekera, Levin, Macdonald, Mandelbrot, Mantegna, Martindale, Michael A. Savageau, Mohr, Olver, Pachucki, Peter J. Mohr, Sergej V. Aksenov, Sidi, Simon, Truesdell, Tsallis, Tsallis, Ulrich D. Jentschura, van Wijngaarden, Weniger, Weniger, Williams, Wolfram, Yule, Zipf, Zörnig   +68 more
core   +2 more sources