Results 51 to 60 of about 2,119,229 (358)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Accuration of Fine Needle Aspiration Biopsy in Musculoskeletal Tumour [PDF]

, 2016
Fine needle aspiration biopsy (FNAB) has been reported to be the preferable choice of biopsy for musculoskeletal tumour. While FNAB appears to have advantages to core biopsy in the aspect of simplicity and cost, the diagnostic accuracy should be the most
Dewo, P. (Punto), Lanodiyu, Z. (Zikrina), Magetsari, R. (Rahadyan), Marseno, H. (Hengkie)   +3 more
core  

Einfluss der Art der Materialgewinnung auf die Diagnosefindung in der Lungenpathologie [PDF]

, 2019
Das Ziel der Arbeit ist die Darstellung der Möglichkeiten der Kryobiopsien für die Diagnostik von Lungenerkrankungen und Pleuraerkrankungen. Es wurde zunächst gezeigt, dass die transbronchialen Kryobiopsien einen deutlichen morphologischen Unterschied ...
Griff, Sergej
core   +1 more source

A biopsy is more than a biopsy [PDF]

Journal of General Internal Medicine, 1998
This issue of JGIM contains a review, by Alguire, about commonly performed skin-biopsy procedures that serves as a comprehensive reference for generalists.1 Generalists need to know more than biopsy technique, however, especially now that managed care is pressuring them to do more themselves and to refer less to consultants like dermatologists.
openaire   +2 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

A prospective adaptive utility trial to validate performance of a novel urine exosome gene expression assay to predict high-grade prostate cancer in patients with prostate-specific antigen 2-10ng/ml at initial biopsy [PDF]

, 2018
BACKGROUND: Discriminating indolent from clinically significant prostate cancer (PCa) in the initial biopsy setting remains an important issue. Prospectively evaluated diagnostic assays are necessary to ensure efficacy and clinical adoption.
Andriole, Gerry, Brown, Gordon, Carroll, Peter, Carter, Ballentine, Donovan, Michael J, Margolis, Eric, McKiernan, James, Noerholm, Mikkel, Partin, Alan, Shore, Neal, Skog, Johan, Thompson, Ian, Torkler, Phillipp   +12 more
core   +1 more source

Preimplantation biopsy predicts delayed graft function, glomerular filtration rate and long-term graft survival of transplanted kidneys [PDF]

, 2016
Background The predictive value of preimplantation biopsies for long-term graft function is often limited by conflicting results. The aim of this study was to evaluate the influence of time-zero graft biopsy histological scores on early and late graft ...
Bianchi, Valentina, Citterio, Franco, FARAGGIANA DI SARZANA, Tullio, Favi, Evaldo, Giannakakis, Konstantinos, Pedroso, José A., Pietroni, Valentina, Romagnoli, Jacopo, Salerno, Maria P., Spagnoletti, Gionata, Toscano, Alessia   +10 more
core   +2 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Performance of PCA3 and TMPRSS2:ERG urinary biomarkers in prediction of biopsy outcome in the Canary Prostate Active Surveillance Study (PASS). [PDF]

, 2019
BackgroundFor men on active surveillance for prostate cancer, biomarkers may improve prediction of reclassification to higher grade or volume cancer.
Bianchi-Frias, Daniella, Brooks, James D, Brown, Marshall D, Carroll, Peter R, Cooperberg, Matthew R, Dash, Atreya, Fabrizio, Michael D, Faino, Anna V, Gleave, Martin E, Lin, Daniel W, Liss, Michael, Morgan, Todd M, Nelson, Peter S, Newcomb, Lisa F, Thompson, Ian M, Wagner, Andrew A, Zheng, Yingye   +16 more
core  

Gaucher Disease and Myelofibrosis: A Combined Disease or a Misdiagnosis? [PDF]

, 2018
Background: Gaucher disease (GD) and primary myelofibrosis (PMF) share similar clinical and laboratory features, such as cytopenia, hepatosplenomegaly, and marrow fibrosis, often resulting in a misdiagnosis.
Cardarelli, L, Foà, R, Giona, F, Mariani, S, Palumbo, G, Santopietro, M   +5 more
core   +1 more source