Results 51 to 60 of about 1,503,790 (360)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Diminishing Use of Liver Biopsy among Liver Transplant Recipients for Hepatitis C. [PDF]

, 2017
Background and Aims: Hepatitis C virus (HCV) cirrhosis is the leading indication for liver transplantation in the United States and recurrent HCV following liver transplantation is a major cause of allograft loss and mortality.
Aby, Elizabeth, Agopian, Vatche, Busuttil, Ronald W, French, Samuel W, Grotts, Jonathan F, Jimenez, Melissa A, Saab, Sammy   +6 more
core   +1 more source

Dynamic gene screening enabled identification of a 10-gene panel for early detection and progression assessment of gastric cancer

Computational and Structural Biotechnology Journal, 2023
Early diagnosis and progression assessment are critical for the timely detection and treatment of gastric cancer (GC) patients. Identification of diagnostic biomarkers for early detection of GC represents an unmet clinical need, and how these markers ...
Fei Long, Shuo Li, Yaqi Xu, Min Liu, Xuan Zhang, Junting Zhou, Yiyi Chen, Yuan Rong, Xiangyu Meng, Fubing Wang   +9 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The potential of hydrogel‐free tumoroids in head and neck squamous cell carcinoma

Cancer Medicine
Background Head and neck malignancy, and in particular squamous cell carcinoma (SCC), is responsible for a significant disease burden globally. The lack of an optimal in vitro model system to accurately recapitulate in vivo response to therapy in HNSCC ...
Michael Wong, Sarju Vasani, Omar Breik, Xi Zhang, Lizbeth Kenny, Chamindie Punyadeera   +5 more
doaj   +1 more source

Role of lung ultrasound inpaediatric patients

Pediatria i Medycyna Rodzinna, 2014
Transthoracic lung ultrasound is ultrasonographic assessment of the lungs, parietal and visceral pleura and the space between these two membranes. It is a part of chest ultrasound examination which also includes assessment of the ribs, intercostal ...
Magdalena Kryger, Wojciech Kosiak
doaj   +1 more source

Artificial intelligence-generated hip radiological measurements are fast and adequate for reliable assessment of hip dysplasia an external validation study

Bone & Joint Open, 2022
AimsHip dysplasia (HD) leads to premature osteoarthritis. Timely detection and correction of HD has been shown to improve pain, functional status, and hip longevity. Several time-consuming radiological measurements are currently used to confirm HD.
Holden Archer, Seth Reine, Ahmed Alshaikhsalama, Joel Wells, Ajay Kohli, Louis Vazquez, Allan Hummer, Matthew D. DiFranco, Richard Ljuhar, Yin Xi, Avneesh Chhabra   +10 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

TEFM facilitates uterine corpus endometrial carcinoma progression by activating ROS-NFκB pathway

Journal of Translational Medicine
Background Mitochondrial transcription elongation factor (TEFM) is a recently discovered factor involved in mitochondrial DNA replication and transcription.
Jia Lei, Qingguo Zhu, Jianghao Guo, Jiaxing Chen, Lixia Qi, Mengmeng Cui, Zhixiong Jiang, Chunhui Fan, Lin Wang, Tianjiao Lai, Yuxi Jin, Lulu Si, Yana Liu, Qi Yang, Dengke Bao, Ruixia Guo   +15 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source