Results 61 to 70 of about 1,636,979 (366)

A biopsy is more than a biopsy [PDF]

Journal of General Internal Medicine, 1998
This issue of JGIM contains a review, by Alguire, about commonly performed skin-biopsy procedures that serves as a comprehensive reference for generalists.1 Generalists need to know more than biopsy technique, however, especially now that managed care is pressuring them to do more themselves and to refer less to consultants like dermatologists.
openaire   +2 more sources

Final trial report of sentinel-node biopsy versus nodal observation in melanoma.

New England Journal of Medicine, 2014
BACKGROUND Sentinel-node biopsy, a minimally invasive procedure for regional melanoma staging, was evaluated in a phase 3 trial. METHODS We evaluated outcomes in 2001 patients with primary cutaneous melanomas randomly assigned to undergo wide excision ...
D. Morton, J. Thompson, A. Cochran, N. Mozzillo, O. Nieweg, D. Roses, H. J. Hoekstra, C. Karakousis, C. Puleo, B. Coventry, M. Kashani-Sabet, B. M. Smithers, Eberhard Paul, W. Kraybill, J. Mckinnon, He-jing Wang, R. Elashoff, M. Faries   +17 more
semanticscholar   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Transcriptional profiles of circulating tumor cells reflect heterogeneity and treatment resistance in advanced prostate cancer

Journal of Experimental & Clinical Cancer Research
Purpose New biomarkers for the detection and monitoring of aggressive variant prostate cancer (AVPC) including therapy-induced neuroendocrine prostate cancer (NEPC) are urgently needed, as measuring prostate-specific antigen (PSA) is not reliable in ...
Lina Bergmann, Sarah Greimeier, Sabine Riethdorf, Tina Rohlfing, Moritz Kaune, Tobias Busenbender, Nadja Strewinsky, Sergey Dyshlovoy, Simon Joosse, Sven Peine, Klaus Pantel, Gunhild von Amsberg, Stefan Werner   +12 more
doaj   +1 more source

Inferior vena cava/aorta diameter index in the assessment of the body fluid status – a comparative study of measurements performed by experienced and inexperienced examiners in a group of young adults

Journal of Ultrasonography, 2014
The assessment of the body fluid status is one the most challenging tasks in clinical practice. Although there are many methods to assess the body fluid status of patients, none of them is fully satisfactory in contemporary medical sciences.
Kaja Durajska, Emilia Januszkiewicz, Łukasz Szmygel, Wojciech Kosiak   +3 more
doaj   +1 more source

Mechanobiology and survival strategies of circulating tumor cells: a process towards the invasive and metastatic phenotype

Frontiers in Cell and Developmental Biology, 2023
Metastatic progression is the deadliest feature of cancer. Cancer cell growth, invasion, intravasation, circulation, arrest/adhesion and extravasation require specific mechanical properties to allow cell survival and the completion of the metastatic ...
Keerthi Kurma, Keerthi Kurma, Keerthi Kurma, Catherine Alix-Panabières, Catherine Alix-Panabières, Catherine Alix-Panabières   +5 more
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Exosomal miRNA profile as complementary tool in the diagnostic and prediction of treatment response in localized breast cancer under neoadjuvant chemotherapy

Breast Cancer Research, 2019
Background Breast cancer patients under neoadjuvant chemotherapy includes a heterogeneous group of patients who eventually develop distal disease, not detectable by current methods.
Alba Rodríguez-Martínez, Diego de Miguel-Pérez, Francisco Gabriel Ortega, José Luis García-Puche, Inmaculada Robles-Fernández, José Exposito, Jordi Martorell-Marugan, Pedro Carmona-Sáez, María del Carmen Garrido-Navas, Christian Rolfo, Hugh Ilyine, José Antonio Lorente, Marta Legueren, María José Serrano   +13 more
doaj   +1 more source

Systematic Review and Meta-Analysis of Native Kidney Biopsy Complications.

American Society of Nephrology. Clinical Journal, 2020
BACKGROUND AND OBJECTIVES Native kidney biopsies are commonly performed in the diagnosis of acute kidney diseases and CKD. Because of the invasive nature of the procedure, bleeding-related complications are not uncommon. The National Institutes of Health,
E. Poggio, R. McClelland, K. Blank, S. Hansen, S. Bansal, A. Bomback, P. Canetta, P. Khairallah, Krzysztof Kiryluk, S. Lecker, G. McMahon, P. Palevsky, S. Parikh, S. Rosas, K. Tuttle, M. Vazquez, A. Vijayan, B. Rovin   +17 more
semanticscholar   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source