Results 91 to 100 of about 6,578 (240)

Insights from a Murine Aortic Transplantation Model [PDF]

, 2016
Transplant vasculopathy (TV) represents a major obstacle to long-term graft survival and correlates with severity of ischemia reperfusion injury (IRI). Donor administration of the nitric oxide synthases (NOS) co-factor tetrahydrobiopterin has been shown ...
Bernhard, David, Brandacher, Gerald, Cardini, Benno, Golderer, Georg, Maglione, Manuel, Messner, Barbara, Oberhuber, Rupert, Pratschke, Johann, Riede, Gregor, Steger, Christina, Watschinger, Katrin, Werner, Ernst R.   +11 more
core   +1 more source

Endothelial histone deacetylase 1 activity impairs kidney microvascular NO signaling in rats fed a high‐salt diet

Acta Physiologica, Volume 240, Issue 9, September 2024.
Abstract Aim We aimed to test the hypothesis that a high‐salt diet (HS) impairs NO signaling in kidney microvascular endothelial cells through a histone deacetylase 1 (HDAC1)‐dependent mechanism. Methods Male Sprague Dawley rats were fed normal salt diet (NS; 0.49% NaCl) or HS (4% NaCl) for 2 weeks. NO signaling was assessed by measuring L‐NAME induced
Luke S. Dunaway, Anthony K. Cook, Cailin E. Kellum, Claudia Edell, Davide Botta, Patrick A. Molina, Randee S. Sedaka, Livius V. d'Uscio, Zvonimir S. Katusic, David M. Pollock, Edward W. Inscho, Jennifer S. Pollock   +11 more
wiley   +1 more source

Is allostery a fuzzy concept?

FEBS Open Bio, Volume 14, Issue 7, Page 1040-1056, July 2024.
Assigning a reaction mechanism to allosteric proteins can be difficult. It is also unclear how many reaction mechanisms qualify as allosteric and the criteria used for assigning such mechanisms. Here, we define these criteria, apply them to a list of allosteric proteins, and suggest that reaction mechanism assignment should be considered preliminary ...
Veronica Morea, Francesco Angelucci, Andrea Bellelli   +2 more
wiley   +1 more source

GV‐971 attenuates the progression of neuromyelitis optica in murine models and reverses alterations in gut microbiota and associated peripheral abnormalities

CNS Neuroscience &Therapeutics, Volume 30, Issue 7, July 2024.
The NMOSD model demonstrated substantial neuroinflammation and neural injury, accompanied by imbalances in gut microbiota, peripheral inflammation, and metabolic disorders, suggesting a potentially vicious cycle that exacerbates disease pathogenesis.
Xinying Yang, Zhongheng Zhangyi, Aisong Yu, Qinming Zhou, Aihua Xia, Ji Qiu, Meixiang Cai, Xingkun Chu, Liang Li, Zhengnan Feng, Zhiyu Luo, Guangqiang Sun, Jing Zhang, Meiyu Geng, Sheng Chen, Zuoquan Xie   +15 more
wiley   +1 more source

Tetrahydrobiopterin (BH4) treatment stabilizes tyrosine hydroxylase: Rescue of tyrosine hydroxylase deficiency phenotypes in human neurons and in a knock‐in mouse model

Journal of Inherited Metabolic Disease, Volume 47, Issue 3, Page 494-508, May 2024.
Abstract Proteostatic regulation of tyrosine hydroxylase (TH), the rate‐limiting enzyme in dopamine biosynthesis, is crucial for maintaining proper brain neurotransmitter homeostasis. Variants of the TH gene are associated with tyrosine hydroxylase deficiency (THD), a rare disorder with a wide phenotypic spectrum and variable response to treatment ...
Kunwar Jung‐KC, Alba Tristán‐Noguero, Altanchimeg Altankhuyag, David Piñol Belenguer, Karina S. Prestegård, Irene Fernandez‐Carasa, Arianna Colini Baldeschi, Maria Sigatulina Bondarenko, Angeles García‐Cazorla, Antonella Consiglio, Aurora Martinez   +10 more
wiley   +1 more source

Mouse models for inherited monoamine neurotransmitter disorders

Journal of Inherited Metabolic Disease, Volume 47, Issue 3, Page 533-550, May 2024.
Abstract Several mouse models have been developed to study human defects of primary and secondary inherited monoamine neurotransmitter disorders (iMND). As the field continues to expand, current defects in corresponding mouse models include enzymes and a molecular co‐chaperone involved in monoamine synthesis and metabolism (PAH, TH, PITX3, AADC, DBH ...
Beat Thöny, Joanne Ng, Manju A. Kurian, Philippa Mills, Aurora Martinez   +4 more
wiley   +1 more source

Dispel some mist on circulating biopterins: measurement, physiological interval and pathophysiological implication [PDF]

, 2023
Shao‐Ting Wang, Haibo Wang
openalex   +1 more source

Drug-induced Parkinson's disease modulates protein kinase A and Olfactory Marker Protein in the mouse olfactory bulb [PDF]

, 2017
Background Olfaction is often affected in parkinsonian patients, but dopaminergic cells in the olfactory bulb are not affected by some Parkinson-inducing drugs.
Caretta, Antonio, Mucignat, Carla
core   +2 more sources

Differential Inhibition of Constitutive and Inducible Nitric Oxide Synthase in Vascular Endothelial Cells by Analogues of Tetrahydrobiopterin [PDF]

, 2017
In the vasculature, a physiologic production of nitric oxide (NO) is maintained by endothelial nitric oxide synthase (eNOS). Induction of inducible nitric oxide synthase (ÍNOS) under inflammatory conditions (e.g. septic shock) resulting in high levels of
Linscheid, Philippe, Mueller, Nicolas J., Schaffner, Andreas, Schoedon, Gabriele, Walter, Roland Β.   +4 more
core  

Tetrahydrobiopterin Synthesis in Rat Cardiac Myocytes; An Event Required for Cytokine-induced NO Generation

Pteridines, 1998
Cardiac myocytes are known to express the high-capacity inducible isoform of nitric oxide (NO) synthase (iNOS). Since tetrahydrobiopterin (BH4) is an essential cofactor for NO formation, we investigated whether BH4 synthesis is required for cytokine ...
Hattori Yoshiyuki, Nakanishi Nobuo, Gross Steven S., Kasai Kikuo   +3 more
doaj   +1 more source