Results 11 to 20 of about 912 (137)

Dysregulation of tetrahydrobiopterin metabolism in myalgic encephalomyelitis/chronic fatigue syndrome by pentose phosphate pathway [PDF]

Journal of Central Nervous System Disease
Background Tetrahydrobiopterin (BH4) and its oxidized derivative dihydrobiopterin (BH2) were found to be strongly elevated in ME/CFS patients with orthostatic intolerance (ME + OI).
Sarojini Bulbule, Carl Gunnar Gottschalk, Molly E. Drosen, Daniel Peterson, Leggy A. Arnold, Avik Roy   +5 more
doaj   +2 more sources

Role of endothelial colony forming cells (ECFCs) Tetrahydrobiopterin (BH4) in determining ECFCs functionality in coronary artery disease (CAD) patients [PDF]

Scientific Reports, 2022
Nitric oxide (NO . ) is critical for functionality of endothelial colony forming cells (ECFCs). Dimerization of endothelial nitric oxide synthase (eNOS) is must to produce NO . and tetrahydrobiopterin (BH4) plays a crucial role in stabilizing this state.
Atanu Sen, Archna Singh, Ambuj Roy, Sujata Mohanty, Nitish Naik, Mani Kalaivani, Lakshmy Ramakrishnan   +6 more
doaj   +2 more sources

Associations of Biopterins and ADMA with Vascular Function in Peripheral Microcirculation from Patients with Chronic Kidney Disease [PDF]

International Journal of Molecular Sciences, 2023
Karolina Kublickiene, Peter Stenvinkel, Lars Löfgren   +2 more
exaly   +2 more sources

Comparative Study of Blood Neopterin and Biopterins in Patients with COVID-19 and Secondary Bacterial Infection [PDF]

Journal of Clinical Medicine
Hiroshi Ichinose, Satoshi Hara, Yutaro Madokoro   +2 more
exaly   +2 more sources

Garlic prevents the oxidizing and inflammatory effects of sepsis induced by bacterial lipopolysaccharide at the systemic and aortic level in the rat. Role of trpv1

Heliyon, 2023
Garlic (Allium sativum) possesses healing properties for diseases like systemic arterial hypertension, cancer and diabetes, among others. Its main component, allicin, binds to the Transient Receptor Potential Vanilloid Type 1 (TRPV1).
Juan Carlos Torres-Narváez, Israel Pérez-Torres, Leonardo del Valle-Mondragón, Vicente Castrejón-Tellez, Verónica Guarner-Lans, María Sánchez-Aguilar, Elvira Varela-López, Álvaro Vargas-González, Gustavo Pastelín-Hernández, Julieta Anabell Díaz-Juárez   +9 more
doaj   +1 more source

Impaired systemic tetrahydrobiopterin bioavailability and increased oxidized biopterins in pediatric falciparum malaria: association with disease severity. [PDF]

PLoS Pathogens, 2015
Decreased bioavailability of nitric oxide (NO) is a major contributor to the pathophysiology of severe falciparum malaria. Tetrahydrobiopterin (BH4) is an enzyme cofactor required for NO synthesis from L-arginine.
Matthew P Rubach, Jackson Mukemba, Salvatore Florence, Bert K Lopansri, Keith Hyland, Alicia D Volkheimer, Tsin W Yeo, Nicholas M Anstey, J Brice Weinberg, Esther D Mwaikambo, Donald L Granger   +10 more
doaj   +1 more source

Age-Dependent Variation in Blood Biopterin Peaks Following Oral Tetrahydrobiopterin Administration in Phenylketonuria. [PDF]

J Inherit Metab Dis
ABSTRACT The correct diagnosis of tetrahydrobiopterin (BH4, sapropterin dihydrochloride)‐responsive phenylketonuria (PKU) and treatment with BH4 are important for prognosis and quality of life. We examined whether age affects biopterin bioavailability following oral BH4 administration in PKU and whether this influences BH4 responsiveness.
Kitayama K, Sakaguchi T, Nakano N, Kabata D, Shintaku H, Hamazaki T.   +5 more
europepmc   +2 more sources

The Nitric Oxide System in Peripheral Artery Disease: Connection with Oxidative Stress and Biopterins

Antioxidants, 2020
Peripheral artery disease (PAD) pathophysiology extends beyond hemodynamics to include other operating mechanisms, including endothelial dysfunction. Oxidative stress may be linked to endothelial dysfunction by reducing nitric oxide (NO) bioavailability.
Ahmed Ismaeel, Evlampia Papoutsi, Dimitrios Miserlis, Ramon Lavado, Gleb Haynatzki, George P. Casale, William T. Bohannon, Robert S. Smith, Jack Leigh Eidson, Robert Brumberg, Aaron Hayson, Jeffrey S. Kirk, Carlos Castro, Ian Sawicki, Charalambos Konstantinou, Luke P. Brewster, Iraklis I. Pipinos, Panagiotis Koutakis   +17 more
doaj   +1 more source

Existence of biopterins and biopterin synthesizing enzymes in human osteoblast and osteosarcoma cells

The Japanese Journal of Pharmacology, 1998
Makio Mogi, Ayami Kondo, Akifumi Togari
exaly   +2 more sources

The Influence of 2,4-Diamino-6-Hydroxypyrimidine and Food Restriction on Tetrahydrobiopterin Metabolism, Neurotransmitters and Behaviour in the Rat

Pteridines, 1991
Administration of 2,4-diamino-6-hydroxypyrimidine (DAHP) in the diet of rats reduced total biopterins in plasma, brain and liver. The levels of dihydropteridine reductase (DHPR) and the rate of biopterin biosynthesis were unaffected.
Cox J., Armstrong R. A., Blair J. A.
doaj   +1 more source