Results 41 to 50 of about 950 (173)
A Novel Multimodal LC–MS/MS Panel for the Comprehensive Diagnosis of Neurometabolic Disorders in CSF
Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.ABSTRACT Metabolic testing of cerebrospinal fluid (CSF) is essential for early diagnosis of neurometabolic disorders. However, the large number of differential diagnoses, the phenotypic variance within a clinical picture, and the disease rarity complicate targeted metabolic diagnostics.
Stine Christ +8 more
wiley +1 more source
Biopterin responsive phenylalanine hydroxylase deficiency [PDF]
Genetics in Medicine, 2004 Phenylketonuria (PKU) is an autosomal recessive disorder caused by mutations in the phenylalanine hydroxylase (PAH) gene. There have been more than 400 mutations identified in the PAH gene leading to variable degrees of deficiency in PAH activity, and consequently a wide spectrum of clinical severity.
Reuben, Matalon +11 more
openaire +2 more sources
, 2015 (A) Oral polybacterial infection significantly reduced serum NO levels (μmoles) and (B) elevated oxidized biopterins levels thus reducing BH4 bioavailability when compared to control mice.
Janet Southerland (760591) +8 more
core +1 more source
Hippo Pathway Drives Durable Non‐Cell‐Autonomous Ferroptosis Resistance in Lung Cancer
Cancer Science, Volume 117, Issue 3, Page 683-694, March 2026.YAP/TAZ, key effectors in lung cancer progression, paradoxically sensitize tumor cells to ferroptosis. This study reveals that YAP/TAZ‐low cells confer non‐cell‐autonomous, GCH1‐mediated durable ferroptosis resistance to neighboring YAP/TAZ‐high cells via a soluble factor, highlighting a Hippo pathway‐linked mechanism of tumor adaptation and survival ...
Mohamed Fathi Saleh +6 more
wiley +1 more source
The FEBS Journal, Volume 293, Issue 6, Page 1754-1770, March 2026.The Leishmania phosphatase PTP1, and possibly the genetically similar PTP2, interacts with the Leishmania transmembrane protein DUF21. When both ptp1 and ptp2 are knocked out of Leishmania (LdΔPTP1/2), the parasite can no longer survive without magnesium in vitro and has reduced viability in the host macrophage. Conversely, in duf21 knockout (LdΔDUF21),
Kayla Paulini +6 more
wiley +1 more source
Journal of Basic Microbiology, Volume 66, Issue 2, February 2026.ABSTRACT Phytophthora parasitica is a generalist phytopathogenic oomycete that infects a series of crops with great economic interest, including tomato, tobacco, and citrus species. Sterols are essential lipids in eukaryotic organisms, playing a fundamental role in the structure and function of the cell membrane.
Pâmela Ponce Martins +7 more
wiley +1 more source
Plasma levels of analytes involved in Arginine/NO pathway.
, 2013 (A) L-arginine (Arg), L-citrulline (Cit), L-ornithine (Orn) were simultaneously determined by LC-MS/MS. (B) Arg bioavailability and the relative activity of arginase and NOS enzymes are expressed as Arg/(Orn+Cit) and Orn/Cit ratios, respectively. (C) The
Fabrizio Veglia (298165) +11 more
core +1 more source
Journal of Basic Microbiology, Volume 66, Issue 2, February 2026.ABSTRACT Monascus fungi are valued for their production of Monacolin K (MK), a bioactive compound with recognized lipid‐lowering and multifunctional properties. To enhance MK yield in solid‐state fermentation, this study combined atmospheric and room‐temperature plasma (ARTP) mutagenesis with L‐arginine supplementation.
Chen Yang, Yang Yajing, Hong Housheng
wiley +1 more source
RBC levels of analytes involved in Arginine/NO pathway.
, 2013 (A) L-arginine (Arg), L-citrulline (Cit), L-ornithine (Orn) were simultaneously determined by LC-MS/MS. (B) Arg bioavailability and the relative activity of arginase and RBC-NOS enzymes are expressed as Arg/(Orn+Cit) and Orn/Cit ratios, respectively. (C)
Fabrizio Veglia (298165) +11 more
core +1 more source
Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale
Geriatrics &Gerontology International, Volume 26, Issue 1, January 2026.ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi +4 more
wiley +1 more source