Results 51 to 60 of about 1,140 (181)

Neopterin as a Tool for Primate Ecoimmunology: Current Knowledge, Practical Application, and New Directions From Captivity to the Wild

American Journal of Primatology, Volume 87, Issue 10, October 2025.
Neopterin is a sensitive and specific biomarker of intracellular pathogen infection and chronic inflammation, and affected by environmental, life‐history, and sex‐contextual factors. This review offers best‐practice guidelines and practical advice on sample collection, storage, and analysis in primates when used for ecoimmunological conservation and ...
Verena Behringer, Caroline Deimel
wiley   +1 more source

Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches. [PDF]

, 2015
BACKGROUND AND PURPOSE: 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4 ) is an essential cofactor for nitric oxide biosynthesis. Substantial clinical evidence indicates that intravenous BH4 restores vascular function in patients.
Brown, PR, Channon, Keith M., Heikal, L, Hussein, D, McDonnell, JM, McNeill, Eileen, Nandi, M, Starr, A, Sutton, BJ   +8 more
core   +3 more sources

Dissecting the genomic regions, candidate genes and pathways using multi‐locus genome‐wide association study for stem rot disease resistance in groundnut

The Plant Genome, Volume 18, Issue 3, September 2025.
Abstract Stem rot, caused by Sclerotium rolfsii Sacc., is a devastating soil‐borne disease causing up to 80% yield losses in groundnut globally. To dissect the genetic basis of resistance, we evaluated a diverse minicore germplasm panel over 3 years in stem rot sick‐field conditions.
H. V. Veerendrakumar, Hari Kishan Sudini, Bangaru Kiranmayee, Talwar Devika, Sunil S. Gangurde, R. P. Vasanthi, A. R. Nirmal Kumar, Sandip K. Bera, Baozhu Guo, Boshou Liao, Rajeev K. Varshney, Manish K. Pandey   +11 more
wiley   +1 more source

Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension [PDF]

, 2015
Overproduction of nitric oxide (NO) is thought to be a key mediator of the vascular dysfunction and severe hypotension in patients with endotoxaemia and septic shock. The contribution of NO produced directly in the vasculature by endothelial cells to the
Channon, Keith M., Chuaiphichai, Surawee, McNeill, Eileen, Nandi, Manasi, Starr, Anna   +4 more
core   +3 more sources

Comparative Genomics Insights Into the Evolutionary Disparities Between Nitroplast‐Evolved Ecotype UCYN‐A2 and Its Closest Relative UCYN‐A1

Ecology and Evolution, Volume 15, Issue 7, July 2025.
This paper conducted comparative genomic analyses among seven UCYN‐A strains in genome content, gene structure, and key metabolic protein genes. In general, our results demonstrated considerable disparities between UCYN‐A1 and UCYN‐A2, providing insights into the evolution of UCYN‐A and nitroplast.
Shiyun Han, Sijia Zhang, Wen Ge, Jianke Yang, Hui Peng, Jinming Gao, Mengsa Zhang, Yingying Xiao, Dongsheng Du, Xianzhao Kan   +9 more
wiley   +1 more source

Endothelial cell tetrahydrobiopterin modulates sensitivity to ang (angiotensin) II–induced vascular remodeling, blood pressure, and abdominal aortic aneurysm [PDF]

, 2018
GTPCH (GTP cyclohydrolase 1, encoded by Gch1) is required for the synthesis of tetrahydrobiopterin; a critical regulator of endothelial NO synthase function.
Channon, Keith M., Chuaiphichai, Surawee, Douglas, Gillian, Hale, Ashley B., Lygate, Craig A., McNeill, Eileen, Patel, Jyoti, Rashbrook, Victoria S., Trelfa, Lucy   +8 more
core   +1 more source

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, Volume 26, Issue 11, June 3, 2025.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

Acrylamide induces spatiotemporal metabolic profiling disturbance via targeting taurine and hypotaurine metabolism during early zebrafish development

Food Frontiers, Volume 6, Issue 1, Page 282-299, January 2025.
This study provides in‐depth evidence on the metabolic regulation of zebrafish embryos with acrylamide exposure at different zebrafish developmental stages. The pattern of significantly changed metabolites revealed that acrylamide exposure has a detrimental effect on early heart development in zebrafish due to the inhibition of de novo synthesis of ...
Anli Wang, Jia Zeng, Xiaoran Song, Yingyu Huang, Jianxin Yao, Li Zhu, Yuchen Gao, Binjie Wang, Yuanzhao Wu, Zhongshi Xu, Ruonan Zheng, Yazhou Qin, Jiye Wang, Weixuan Yao, Xuzhi Wan, Haoyu Li, Pan Zhuang, Jingjing Jiao, Shulin Zhuang, Yu Zhang   +19 more
wiley   +1 more source

Oxidative Stress and Immune System in Vitiligo and Thyroid Diseases. [PDF]

, 2015
Vitiligo is an acquired dermatological disease frequently associated with autoimmune thyroid disorders. Several theories have been proposed so far to unravel the complex vitiligo pathogenesis.
Colucci, Roberta, Dragoni, Federica, Moretti, Silvia   +2 more
core   +4 more sources

A Single‐Center Retrospective Cohort Study of Biopterin Metabolism Disorders in the United Arab Emirates

JIMD Reports, Volume 66, Issue 1, January 2025.
ABSTRACT Background Tetrahydrobiopterin (BH4) deficiencies comprise a group of five neurometabolic disorders caused by five genetic defects responsible for BH4 biosynthesis and regeneration. Their global prevalence remains unknown, and variance exists among different countries.
Omar Jarrah, Mahmood Nouri, Aisha Al Shamsi   +2 more
wiley   +1 more source