Results 51 to 60 of about 950 (173)

Tetrahydrobiopterin administration facilitates amphetamine-induced dopamine release and motivation in mice

, 2020
International audienceDopamine (DA) is a critical neurotransmitter involved in motivational processes. Tetrahydrobiopterin (BH4) is an essential cofactor for tyrosine hydroxylase, the rate-limiting enzyme in DA synthesis.
OUMMADI, Asma, CALON, Frederic, Calon, F., TOURNISSAC, Marine, Azzougen, B., Ducrocq, F., Oummadi, A., Lo, A., Trifilieff, P., Moussa, F., Vancassel, Sylvie, FANET, Hortense, de Smedt-Peyrusse, V., Capuron, Lucile, Bourrassa, P., Tournissac, M., TRIFILIEFF, Pierre, DUCROCQ, Fabien, Fanet, H., Layé, Sophie, DE SMEDT-PEYRUSSE, Veronique   +20 more
core   +1 more source

Genome‐Wide Protein Interaction Analysis in Parasitic Gyrodactylus Flatworms–Fish Hosts System and Drug Target Identification

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Genomic data offer a powerful tool for studying the molecular interactions between parasites and their hosts, but they remain scarce for parasitic monogenean flatworms. This study presents the first high‐quality phased genome assembly for monogeneans (Gyrodactylus kobayashii), and uses it to predict key interacting proteins between monogenean parasite ‐
Dong Zhang, Jie‐Mei Zhao, Chuan‐Yu Xiang, Yi‐Wen Ma, Hong‐Peng Lei, Yu‐Ying Shi, Shun Zhou, Xiaofei Zeng, Jinsong Chen, Fei Liu, Benhe Zeng, Rui Song, Ye Hu, Feng Zhang, Xiang Liu, Wen‐Xiang Li, Gui‐Tang Wang, Ivan Jakovlić   +17 more
wiley   +1 more source

Urine biopterin concentrations at enrollment in the 4 clinical groups.

, 2015
A: Comparison of total urine biopterins (tetrahydrobiopterin [BH4] + dihydrobiopterin [BH2] + biopterin [B0]) concentrations at enrollment for healthy controls (HC, n = 111), uncomplicated malaria (UM, n = 55), cerebral malaria (CM, n = 45) and non ...
J. Brice Weinberg (271620), Alicia D. Volkheimer (701241), Tsin W. Yeo (218400), Bert K. Lopansri (271621), Donald L. Granger (271619), Esther D. Mwaikambo (323802), Keith Hyland (142148), Nicholas M. Anstey (35535), Matthew P. Rubach (323793), Jackson Mukemba (323796), Salvatore Florence (323797)   +10 more
core   +1 more source

Consensus Guideline for the Diagnosis and Treatment of Tyrosine Hydroxylase (TH) Deficiency

Journal of Inherited Metabolic Disease, Volume 48, Issue 6, November 2025.
ABSTRACT Tyrosine hydroxylase (TH) catalyses the rate‐limiting step in dopamine biosynthesis. Autosomal recessive tyrosine hydroxylase deficiency (THD) leads to clinical phenotypes reflecting the deficiency of dopamine, norepinephrine, or epinephrine in the central nervous system (CNS), presenting along a continuous spectrum from mild to severe forms ...
Mariya Sigatullina Bondarenko, Oya Kuseyri Hübschmann, Jan Kulhánek, Roser Pons, Toni S. Pearson, Kathrin Jeltsch, Ivana Badnjarevic, Tessa Wassenberg, Gabriella Horvath, Galina Stevanovic, Manju A. Kurian, Elisenda Cortès‐Saladelafont, Agathe Roubertie, Vincenzo Leuzzi, Mariarita Bertoldi, Mario Mastrangelo, Birgit Assmann, THD Guidelines Working Group, Ines Denzler, Clarisa Maxit, Natalia Alexandra Julia‐Palacios, Shekeeb Mohammad, Helly Goez, Wai‐Ian Yeung, Tomáš Honzík, Ivana Kavecan, Alba Tristán‐Noguero, Alberto Burlina, Daniela Gueraldi, Sushil Bandodkar, Willemsen Michel, Francesco Porta, Sheila Wong, Filippo Manti, Reem Alkhater, Chris Mühlhausen, Alice Kuster, Dimitrios Zafeiriou, Paulo Sgobbi, Wladimir Bocca Vieira de Rezende Pinto, Angeles Garcia‐Cazorla, Thomas Opladen   +41 more
wiley   +1 more source

Neopterin as a Tool for Primate Ecoimmunology: Current Knowledge, Practical Application, and New Directions From Captivity to the Wild

American Journal of Primatology, Volume 87, Issue 10, October 2025.
Neopterin is a sensitive and specific biomarker of intracellular pathogen infection and chronic inflammation, and affected by environmental, life‐history, and sex‐contextual factors. This review offers best‐practice guidelines and practical advice on sample collection, storage, and analysis in primates when used for ecoimmunological conservation and ...
Verena Behringer, Caroline Deimel
wiley   +1 more source

Dissecting the genomic regions, candidate genes and pathways using multi‐locus genome‐wide association study for stem rot disease resistance in groundnut

The Plant Genome, Volume 18, Issue 3, September 2025.
Abstract Stem rot, caused by Sclerotium rolfsii Sacc., is a devastating soil‐borne disease causing up to 80% yield losses in groundnut globally. To dissect the genetic basis of resistance, we evaluated a diverse minicore germplasm panel over 3 years in stem rot sick‐field conditions.
H. V. Veerendrakumar, Hari Kishan Sudini, Bangaru Kiranmayee, Talwar Devika, Sunil S. Gangurde, R. P. Vasanthi, A. R. Nirmal Kumar, Sandip K. Bera, Baozhu Guo, Boshou Liao, Rajeev K. Varshney, Manish K. Pandey   +11 more
wiley   +1 more source

Tetrahydrobiopterin metabolism, neurotransmitters and behaviour in the rat [PDF]

Various neurotoxins were investigated to assess their suitability for developing an animal model to study partial brain BH4 deficiency, neurotransmitters and behavioural alterations.
Cox, Juliette
core  

Impairment of nitrergic system and delayed gastric emptying in low density lipoprotein receptor deficient female mice

, 2011
Background In the current study, we have investigated whether low density lipoprotein receptor knockout mice (LDLR-KO), moderate oxidative stress model and cholesteremia burden display gastroparesis and if so whether nitrergic system is involved in this ...
Channon, Keith, A. B. Hale, Hale, AB, Mukhopadhyay, S, K. M. Channon, Ravella, K, Channon, KM, K. Ravella, S. Mukhopadhyay, V. Chinnathambi, Chinnathambi, V, P. R. Gangula, Gangula, PR   +12 more
core   +1 more source

Dystonia and Biopterin Deficiency

Pediatric Neurology Briefs, 1988
Five patients with childhood dystonia associated with reduced CSF biopterin, responsive to levodopa, and characterized by diurnal and exertional variation are reported from the Developmental and Metabolic Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD.
openaire   +4 more sources

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.

, 2005
AIMS/HYPOTHESIS: Impaired nitric oxide (NO) bioactivity and increased superoxide (SO) production are characteristics of vascular endothelial dysfunction in diabetes. The underlying mechanisms remain unknown.
Channon, Keith, Khoo, J, Mussa, S, Alp, NJ, Channon, KM, Cai, S   +5 more
core   +1 more source