Results 61 to 70 of about 950 (173)

Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency in Dutch neonates

, 2001
Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency in Dutch neonates. Spaapen LJ, Bakker JA, Velter C, Loots W, Rubio-Gonzalbo ME, Forget PP, Dorland L, De Koning TJ, Poll-The BT, Ploos van Amstel HK, Bekhof J, Blau N, Duran M ...
M. E. Rubio‐Gonzalbo, Rubio-Gonzalbo, M. E., Forget, Ph., Duran, M., J. A. Bakker, M. Duran, Bakker, J.A., Blau, N., Rubio-Gozalbo, M. E., B. T. Poll‐The, Forget, P. P., C. Velter, T. J. De Koning, Bakker, J. A., Spaapen, L. J., van Ploos Amstel, H.K., N. Blau, L. J. M. Spaapen, L. Dorland, Poll-The, B. T., Bekhof, J., W. Loots, P. P. Forget, H. K. Ploos Van Amstel, de Koning, T.J., Rubio-Gozalbo, M.E., de Koning, T. J., Ploos van Amstel, H. K., Spaapen, L.J.M., Velter, C., Loots, W., the Poll, B.T., J. Bekhof, Dorland, L.   +33 more
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Targeting the trypanosomatidic enzymes pteridine reductase and dihydrofolate reductase.

, 2013
Drugs currently in use against Leishmania and Trypanosoma infections have limitations in terms of efficacy, safety, duration of the treatment, toxicity and resistance.
Puneet Saxena, COSTI, Maria Paola, Maria Paola Costi, Valeria Losasso, FERRARI, Stefania, Stefania Ferrari, SAXENA, PUNEET   +6 more
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Tetrahydrobiopterin synthesis and inducible nitric oxide production in pulmonary artery smooth muscle

, 1994
We recently reported (Am. J. Respir. Cell Mol. Biol. 7: 471-476, 1992) that a mixture of lipopolysaccharide (LPS) and cytokines produced a time-dependent increase in mRNA and protein expression of inducible nitric oxide synthase (iNOS) in cultured rat ...
M. Di Silvio, H. Kagamiyama, T. R. Billiar, D. K. Nakayama, K. Hatakeyama, D. A. Geller, G. Bloomgarden, P. Davies, R. L. Simmons, B. R. Pitt   +9 more
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Peri-operative endothelial dysfunction in patients undergoing minor abdominal surgery:An observational study

, 2019
BACKGROUND: Myocardial injury after noncardiac surgery is common and associated with major adverse cardiac events. Surgery induces acute endothelial dysfunction, which might be central in the pathophysiology of myocardial injury; however, the ...
Busch, Sarah Victoria Ekeløf, Godthaab, Camilla, Schou-Pedersen, Anne Marie Voigt, Lykkesfeldt, Jens, Gögenur, Ismael   +4 more
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Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.

, 2009
Tetrahydrobiopterin (BH4) is a critical determinant of endothelial nitric-oxide synthase (eNOS) activity. In the absence of BH4, eNOS becomes "uncoupled" and generates superoxide rather than NO.
Al-Wakeel, Y, Channon, Keith, Warrick, N, Crabtree, MJ, Hale, AB, Alp, NJ, Channon, KM, Tatham, AL, Cai, S   +8 more
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Tetrahydrobiopterin Metabolism in Mental Retardation [PDF]

Optimal ‘conditions for the separation and detection of pteridines by high performance liquid chromatography (HPLC) were obtained. The retention time, reproducibility relative fluorescence and minimal detection limits of various pterins under fixed ...
Morar, Chandrakant
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Tetrahydrobiopterin Metabolism in Mental Disorders [PDF]

Changes in DHPR activity in those aged 12 and under with a variety of mental disorders were investigated using dried blood spots on Guthrie cards. DHPR activity was found to be lowered in autism and Rett's syndrome.
Cowburn, James D.
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Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation

, 2012
Tetrahydrobiopterin (BH4) is an essential cofactor of nitric oxide synthases (NOS). Oral BH4 supplementation preserves cardiac function in animal models of cardiac disease; however, the mechanisms underlying these findings are not completely understood ...
Liu, X, Carnicer, Ricardo, Crabtree, Mark, Hale, Ashley B., Bendall, JK, Zhang, Mei Hua, Alp, NJ, Liu, Xing, Surdo, NC, Bendall, Jennifer K., Suffredini, Silvia, Reilly, S, Surdo, Nicoletta C., Reilly, Svetlana, Channon, Keith, Zhang, MH, Casadei, Barbara, Hale, AB, Channon, KM, Suffredini, S, Lim, Gregory B.S., Carnicer, R, Crabtree, MJ, Lim, GBS, Alp, Nicholas J., Casadei, B   +25 more
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P644Mechanisms of myocardial nitroso redox imbalance following elective cardiac surgery on cardiopulmonary bypass.

, 2014
BACKGROUND AND AIMS: The mechanisms responsible for myocardial stunning after cardiac surgery are only partially understood, although ischemia - reperfusion (IR) injury associated with cardio pulmonary bypass (CPB) may play an important role.
De Silva, R, Crabtree, M, Goodfellow, N, Zhang, M, Reilly, S, Nahar, K, Jayaram, R, Casadei, B, Crabtree, Marc, Sayeed, R   +9 more
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P683The role of nitric oxide synthase (NOS) and its essential cofactor tetrahydrobiopterin (BH4) in diabetic cardiomyopathy.

, 2014
PURPOSE: Diabetes can impact on cardiovascular health by causing a distinct condition termed "diabetic cardiomyopathy". Its characteristic left ventricular (LV) diastolic dysfunction has been associated with interstitial fibrosis, reduced NO availability,
Duglan, D, Channon, K, Carnicer, R, Hale, A, Casadei, B, Simon, J, Chuaiphichai, S   +6 more
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