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Children and Adolescents with Early Treated Phenylketonuria: Cognitive Development and Fluctuations of Blood Phenylalanine Levels. [PDF]
Int J Environ Res Public HealthFeldmann R +4 more
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Current state of the treatment landscape of phenylketonuria. [PDF]
Orphanet J Rare DisNulmans I +4 more
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Liebigs Annalen der Chemie, 1989
AbstractThe synthesis of (‐)‐biopterin (1) was accomplished by employing (1S,2S)‐1‐(2‐furyl)‐2‐(trityloxy)‐1‐propanol (6), derived from ethyl (S)‐lactate, as building block for the side chain.
Kenji Mori, Haruhiko Kikuchi
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AbstractThe synthesis of (‐)‐biopterin (1) was accomplished by employing (1S,2S)‐1‐(2‐furyl)‐2‐(trityloxy)‐1‐propanol (6), derived from ethyl (S)‐lactate, as building block for the side chain.
Kenji Mori, Haruhiko Kikuchi
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Neurochemical Research, 1976
Intraperitoneally injected [(14)C]biopterin (B), dihydrobiopterin (BH2), and tetrahydrobiopterin (BH4) penetrated the brain rapidly, but in amounts sufficient to represent only a minor source of supply. Unlike isobiopterin, B was rapidly reduced to BH2 in brain.
E M, Gal, G, Hanson, A, Sherman
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Intraperitoneally injected [(14)C]biopterin (B), dihydrobiopterin (BH2), and tetrahydrobiopterin (BH4) penetrated the brain rapidly, but in amounts sufficient to represent only a minor source of supply. Unlike isobiopterin, B was rapidly reduced to BH2 in brain.
E M, Gal, G, Hanson, A, Sherman
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Biosynthesis of Biopterin by Rat Brain
Journal of Neurochemistry, 1982Abstract: A method for the determination of [14C]biopterin biosynthesis from [14C]guanosine‐5′‐triphosphate by a desalted preparation from rat striatum, based on sequential reverse‐phase and cation‐exchange high performance liquid chromatography, is described.
G, Kapatos, S, Katoh, S, Kaufman
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Pteridine diuretics as biopterin antagonists
Biochemical Pharmacology, 1974Abstract A series of pteridines having varying degrees of diuretic activity were tested for their effects on the growth of the pteridine-requiring flagellate, Crithidia fasciculata . Inhibition of growth was correlated with diuretic activity insofar as compounds devoid of diuretic effects were uninhibitory and active inhibitors were also good to ...
V C, Dewey, G W, Kidder
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Physiological and clinical chemistry of biopterin
Medicinal Research Reviews, 1989Chimie, dosage de la biopterine. Biosynthese de la tetrahydrobiopterine. Role physiologique de la tetrahydrobiopterine comme cofacteur des monooxygenases necessitant la pterine.
T, Nagatsu, S, Matsuura, T, Sugimoto
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Biopterin and neopterin in human saliva
Life Sciences, 1989Presence of biopterin and neopterin in human saliva was investigated by HPLC after iodine oxidation in acidic medium. Concentrations of biopterin and neopterin (M +/- SEM) were 1.271 +/- 0.254 and 0.358 +/- 0.075 ng per ml, respectively, in saliva of apparently healthy young male adults, ages 20 to 22 years (n = 9).
S, Katoh +3 more
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Psychiatric Manifestations in Patients with Biopterin Defects
Neuropediatrics, 2022AbstractPsychiatric manifestations in patients with tetrahydrobiopterin (BH4) defects are common, and may occur even with treatment of the underlying disorder. The neurobiological background of these conditions has been linked to abnormalities of neurotransmitters, such as dopamine, serotonin, norepinephrine, and gamma-aminobutyric acid.
Maksim Parfyonov +4 more
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Neurochemical Research, 1981
Repeated intraventricular injections of 2,4-diamino-6-hydroxypyrimidine (DAO-Pyr), inhibitor of D-erythro-q-dihydroneopterin triphosphate synthetase, inhibited q-BH2 synthesis from GTP, markedly increased accumulation of 2-amino-4-hydroxy-5 (or -6)-formamido-6-triphosphoribosylaminopyrimidine (FPyd-P3) and brought about a 60% decrease in the in vivo of
E M, Gál, D H, Whitacre
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Repeated intraventricular injections of 2,4-diamino-6-hydroxypyrimidine (DAO-Pyr), inhibitor of D-erythro-q-dihydroneopterin triphosphate synthetase, inhibited q-BH2 synthesis from GTP, markedly increased accumulation of 2-amino-4-hydroxy-5 (or -6)-formamido-6-triphosphoribosylaminopyrimidine (FPyd-P3) and brought about a 60% decrease in the in vivo of
E M, Gál, D H, Whitacre
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