Results 51 to 60 of about 1,785 (203)

Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches. [PDF]

, 2015
BACKGROUND AND PURPOSE: 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4 ) is an essential cofactor for nitric oxide biosynthesis. Substantial clinical evidence indicates that intravenous BH4 restores vascular function in patients.
Brown, PR, Channon, Keith M., Heikal, L, Hussein, D, McDonnell, JM, McNeill, Eileen, Nandi, M, Starr, A, Sutton, BJ   +8 more
core   +3 more sources

Consensus Integration of Multiomics Data With Machine Learning Algorithms Reveals Heterogeneous Molecular Subtypes and Enables Personalized Treatment Strategies for Hepatocellular Carcinoma

Human Mutation, Volume 2025, Issue 1, 2025.
Background Cancers are characterized by high heterogeneity. This study seeks to identify the factors driving hepatocellular carcinoma (HCC) heterogeneity to aid in prognostic stratification and inform personalized treatment approaches. Methods We used a computational pipeline to integrate multiomics data from HCC patients, applying 10 clustering ...
Zhipeng Jin, Kun Fang, Xue Zhang, Mengying Song, Hong Jiang, Yefu Liu, Sujit Nair   +6 more
wiley   +1 more source

Redox sensor and effector functions of tetrahydrobiopterin and the mitochondria in molecular models of cardiovascular disease [PDF]

, 2018
Tetrahydrobiopterin (BH4) is a redox active molecule that is essential for the production of nitric oxide (NO) by the NO synthase (NOS) enzymes. Loss of endothelial BH4 leads to decreased NO and increased superoxide generation by endothelial NOS (eNOS ...
Bailey, Jade
core   +1 more source

Tetrahydrobiopterin protects against hypertrophic heart disease independent of myocardial nitric oxide synthase coupling [PDF]

, 2016
Nitric oxide synthase uncoupling occurs under conditions of oxidative stress modifying the enzyme's function so it generates superoxide rather than nitric oxide.
Bedja, D, Carnicer, R, Casadei, Barbara, Channon, KM, Duglan, D, Hahn, VS, Hashimoto, T, Kass, DA, Recalde, A, Sivakumaran, V, Zhu, G   +10 more
core   +3 more sources

Attenuating susceptibility to ascites in cold‐stressed broiler chickens fed canola meal‐based diets by supplementing arginine or guanidinoacetic acid, either alone or in combination with phenylalanine

Veterinary Medicine and Science, Volume 10, Issue 6, November 2024.
For ARG subscript: Decreased ascites mortality by increased plasma nitric oxide (NO), decreased RV:TV ratio and improved blood oxygen levels. For PHE subscript: Improved feed conversion ratio and decreased ascites susceptibility when combined with ARG or GAA.
Negin Delfani, Mohsen Daneshyar, Parviz Farhoomand, Sina Payvastegan, Younes Ali Alijoo, Gholamreza Najafi   +5 more
wiley   +1 more source

Endothelial cell tetrahydrobiopterin modulates sensitivity to ang (angiotensin) II–induced vascular remodeling, blood pressure, and abdominal aortic aneurysm [PDF]

, 2018
GTPCH (GTP cyclohydrolase 1, encoded by Gch1) is required for the synthesis of tetrahydrobiopterin; a critical regulator of endothelial NO synthase function.
Channon, Keith M., Chuaiphichai, Surawee, Douglas, Gillian, Hale, Ashley B., Lygate, Craig A., McNeill, Eileen, Patel, Jyoti, Rashbrook, Victoria S., Trelfa, Lucy   +8 more
core   +1 more source

Comparative analysis of gene and disease selection in genomic newborn screening studies

Journal of Inherited Metabolic Disease, Volume 47, Issue 5, Page 945-970, September 2024.
Abstract Genomic newborn screening (gNBS) is on the horizon given the decreasing costs of sequencing and the advanced understanding of the impact of genetic variants on health and diseases. Key to ongoing gNBS pilot studies is the selection of target diseases and associated genes to be included.
Isabel R. Betzler, Maja Hempel, Ulrike Mütze, Stefan Kölker, Eva Winkler, Nicola Dikow, Sven F. Garbade, Christian P. Schaaf, Heiko Brennenstuhl   +8 more
wiley   +1 more source

Endothelial histone deacetylase 1 activity impairs kidney microvascular NO signaling in rats fed a high‐salt diet

Acta Physiologica, Volume 240, Issue 9, September 2024.
Abstract Aim We aimed to test the hypothesis that a high‐salt diet (HS) impairs NO signaling in kidney microvascular endothelial cells through a histone deacetylase 1 (HDAC1)‐dependent mechanism. Methods Male Sprague Dawley rats were fed normal salt diet (NS; 0.49% NaCl) or HS (4% NaCl) for 2 weeks. NO signaling was assessed by measuring L‐NAME induced
Luke S. Dunaway, Anthony K. Cook, Cailin E. Kellum, Claudia Edell, Davide Botta, Patrick A. Molina, Randee S. Sedaka, Livius V. d'Uscio, Zvonimir S. Katusic, David M. Pollock, Edward W. Inscho, Jennifer S. Pollock   +11 more
wiley   +1 more source

Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension [PDF]

, 2015
Overproduction of nitric oxide (NO) is thought to be a key mediator of the vascular dysfunction and severe hypotension in patients with endotoxaemia and septic shock. The contribution of NO produced directly in the vasculature by endothelial cells to the
Channon, Keith M., Chuaiphichai, Surawee, McNeill, Eileen, Nandi, Manasi, Starr, Anna   +4 more
core   +3 more sources

Is allostery a fuzzy concept?

FEBS Open Bio, Volume 14, Issue 7, Page 1040-1056, July 2024.
Assigning a reaction mechanism to allosteric proteins can be difficult. It is also unclear how many reaction mechanisms qualify as allosteric and the criteria used for assigning such mechanisms. Here, we define these criteria, apply them to a list of allosteric proteins, and suggest that reaction mechanism assignment should be considered preliminary ...
Veronica Morea, Francesco Angelucci, Andrea Bellelli   +2 more
wiley   +1 more source