Results 41 to 50 of about 39,113 (232)

Neuroinflammation alters cellular proteostasis by producing endoplasmic reticulum stress, autophagy activation and disrupting ERAD activation

Scientific Reports, 2017
Proteostasis alteration and neuroinflammation are typical features of normal aging. We have previously shown that neuroinflammation alters cellular proteostasis through immunoproteasome induction, leading to a transient decrease of proteasome activity ...
Cristina Pintado, Sandra Macías, Helena Domínguez-Martín, Angélica Castaño, Diego Ruano   +4 more
doaj   +1 more source

NUAK1 coordinates growth factor-dependent activation of mTORC2 and Akt signaling

Cell & Bioscience, 2023
Background mTORC2 is a critical regulator of cytoskeleton organization, cell proliferation, and cancer cell survival. Activated mTORC2 induces maximal activation of Akt by phosphorylation of Ser-473, but regulation of Akt activity and signaling crosstalk
Mario Palma, Elizabeth Riffo, Alejandro Farias, Viviana Coliboro-Dannich, Luis Espinoza-Francine, Emilia Escalona, Roberto Amigo, José L. Gutiérrez, Roxana Pincheira, Ariel F. Castro   +9 more
doaj   +1 more source

The Sponge-Derived Brominated Compound Aeroplysinin-1 Impairs the Endothelial Inflammatory Response through Inhibition of the NF-κB Pathway

Marine Drugs, 2022
(+)-Aeroplysinin-1 (Apl-1) is a brominated compound isolated from the marine sponge Aplysina aerophoba that exhibits pleiotropic bioactive effects, impairing cell growth in cancer cells, inhibiting angiogenesis in vitro and in vivo and modulating the ...
Isabel Vidal, Laura Castilla, Ana Dácil Marrero, Inés Bravo-Ruiz, Manuel Bernal, Inmaculada Manrique, Ana R. Quesada, Miguel Ángel Medina, Beatriz Martínez-Poveda   +8 more
doaj   +1 more source

SMARTeaching: Uso de dispositivos móviles en el aula y eficacia de las clases presenciales [PDF]

, 2018
Sección Deptal. de Bioquímica y Biología Molecular (Biológicas)Fac.
Feito Castellano, María José, García Segura, Juan Manuel, Lacadena García-Gallo, Javier, Lainez Ferrando, Alfredo, Luque García, José Luis, Ortega Gutiérrez, Silvia, OñaderraA Sánchez, Mercedes, Pérez-Gil, Jesús, Sánchez García, Cristina   +8 more
core   +1 more source

Analysis of Gene Expression in Aedes aegypti Suggests Changes in Early Genetic Control of Mosquito Development

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
ABSTRACT Aedes aegypti, a critical vector for tropical diseases, poses significant challenges for studying its embryogenesis due to difficulties in removing its rigid chorion and achieving effective fixation for in situ hybridization. Here, we present novel methodologies for fixation, dechorionation, DAPI staining, and in situ hybridization, enabling ...
Renata Coutinho‐dos‐Santos, Danielle Santos, Lupis Ribeiro, Jonathan J. Mucherino‐Muñoz, Marcelle Uhl, Carlos Logullo, A. Mendonça‐Amarante, M. Fantappie, Rodrigo Nunes‐da‐Fonseca   +8 more
wiley   +1 more source

Severo Ochoa: Su compromiso con el desarrollo de la bioquímica y biología molecular en España [PDF]

, 2023
César de Haro Castella
openalex   +1 more source

Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development

Environmental Toxicology, EarlyView.
ABSTRACT According to the developmental origins of health and disease hypothesis, perinatal exposure to an environmental toxicant during the development of the nervous system could cause a permanent cellular modification that may promote the appearance of neurodegenerative diseases at an older age.
Ester López‐Gallardo, Patricia Meade, Irene Jiménez‐Salvador, Carmen Hernández‐Ainsa, Eldris Iglesias, Alba Pesini, Nuria Garrido‐Pérez, Sonia Emperador, David Pacheu‐Grau, Pilar Bayona‐Bafaluy, Eduardo Ruiz‐Pesini   +10 more
wiley   +1 more source

New evolving strategies revealed by transcriptomic analysis of a fur− mutant of the cyanotrophic bacterium Pseudomonas pseudoalcaligenes CECT 5344

Microbial Biotechnology, 2020
Summary The transcriptomic analysis (RNA‐seq) of a fur mutant of P. pseudoalcaligenes CECT 5344 has revealed that Fur regulates the expression of more than 100 genes in this bacterial strain, most of them negatively.
Gracia Becerra, María Isabel Igeño, Faustino Merchán, Rubén Sánchez‐Clemente, Rafael Blasco   +4 more
doaj   +1 more source

Aumentando la presencia de la UCM en los MOOCs: Puesta en marcha de un curso online sobre neurociencia [PDF]

, 2017
Sección Deptal. de Bioquímica y Biología Molecular (Medicina)Fac.
De Lago Femia, Eva, Fernández Ruiz, José Javier, García García, María Concepción, Ramos Atance, José Antonio, Rodríguez Cueto, Carmen, Sagredo Esquioga, Onintza   +5 more
core   +1 more source

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source