Results 61 to 70 of about 8,872 (134)

p53 Genetics and Biology in Lung Carcinomas: Insights, Implications and Clinical Applications

Biomedicines
The TP53 gene is renowned as a tumor suppressor, playing a pivotal role in overseeing the cell cycle, apoptosis, and maintaining genomic stability. Dysregulation of p53 often contributes to the initiation and progression of various cancers, including ...
Dixan A. Benitez, Guadalupe Cumplido-Laso, Marcos Olivera-Gómez, Nuria Del Valle-Del Pino, Alba Díaz-Pizarro, Sonia Mulero-Navarro, Angel Román-García, Jose Maria Carvajal-Gonzalez   +7 more
doaj   +1 more source

Vascular Smooth Muscle Cell Migration and P70S6K: Key Players in Intimal Hyperplasia Development

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Vascular smooth muscle cell (VSMC) recruitment and activation by vessel injury cause intimal hyperplasia (IH) and restenosis. Drug‐eluting stents releasing mTOR (mechanistic target of rapamycin) blockers (sirolimus, everolimus [EV]) improve ...
Sara Moreno‐Estar, Pilar Cidad, Marycarmen Arevalo‐Martinez, Ana M. Portillo, Marcos Sacristan‐Moraleda, Esperanza Alonso, Jose R. Lopez‐Lopez, M. Teresa Perez‐Garcia   +7 more
doaj   +1 more source

Structural and Functional Characterization of LIMCH1 and Its Agmatinase-like Region: A Case of Catalysis in a Highly Disordered Protein

Biomolecules
Agmatine is a biogenic amine that functions as a neurotransmitter and exhibits anticonvulsant, antineurotoxic, and antidepressant properties. It can be metabolized into putrescine and urea by canonical agmatinases or by the agmatinase-like protein (ALP),
María-Belén Reyes, Allison Fuentes, Diego Bustamante, Fernando Retamal, Ignacia Lillo, Cristián Villegas, Juan-Pablo Carrasco, Martin Pereira-Silva, Marcell Gatica, Juan Román, Maximiliano Figueroa, Yamil Neira, José Martínez-Oyanedel, Víctor Castro-Fernández, Elena Uribe   +14 more
doaj   +1 more source

Targeting NOX2 and glycolytic metabolism as a therapeutic strategy in acute myeloid leukaemia

Biomarker Research
Acute myeloid leukaemia (AML) is a highly heterogeneous malignancy, with a poor 5-year overall survival rate of approximately 30%. Consequently, the search for novel therapeutic strategies is ongoing, and the identification of new vulnerabilities could ...
Carla Ijurko, Marta Romo-González, Rodrigo Prieto-Bermejo, María Díez-Campelo, María-Belén Vidriales, Sandra Muntión, Fermín Sánchez-Guijo, Jesús Sánchez-Yagüe, Ángel Hernández-Hernández   +8 more
doaj   +1 more source

Exploring the Tenebrio molitor gut microbiota response to LDPE and PET: putative genetic indicators and methodological insights

Frontiers in Microbiology
Insect gut microbiomes are recognized as potential reservoirs of enzymatic activities relevant to plastic metabolism. Here, we investigated the taxonomic and functional dynamics of the Tenebrio molitor gut microbiota under dietary exposure to low-density
K. Biełło, G. Rodríguez-Caballero, D. Becerra-Mora, N. Dorado-Blanco, L. P. Sáez-Melero, C. Moreno-Vivián, V. M. Luque-Almagro, A. Olaya-Abril, M. D. Roldán   +8 more
doaj   +1 more source

Caveolin-1 modulates Notch transcriptional activity during in vitro respiratory multiciliated cell maturation

Scientific Reports
The airway epithelium, a sophisticated multicellular layer lining the respiratory tract, serves as our first line of defense against pathogens, allergens, and environmental pollutants. Recent studies have illuminated the intricate interplay between basal
Marcos Olivera-Gómez, Guadalupe Cumplido-Laso, Dixan Agustín Benitez, Juan Francisco Barrera-Lopez, Nuria Del Valle-Del Pino, Alba Díaz-Pizarro, Mónica Toledano-Donado, Mauro Catala-Montoro, Sonia María Mulero-Navarro, Ángel Carlos Roman, Miguel Ángel Del Pozo , José María Carvajal-Gonzalez   +11 more
doaj   +1 more source

70 Years of DON and Beyond: Glutaminase Inhibition as a Synergistic Strategy in Cancer Combination Therapy

Pharmaceutics
Personalized oncology seeks to selectively block specific dysregulated pathways to arrest cancer development. Increased glutamine metabolism is a hallmark of cancer, and 6-diazo-5-oxo-L-norleucine (DON), a structural analog of L-glutamine, was the first ...
José A. Campos-Sandoval, Juan De los Santos-Jiménez, Javier Márquez, José M. Matés   +3 more
doaj   +1 more source

Altered PTPN13–β-catenin interaction by pathogenic mutations and involvement of this axis in B-cell receptor signalling

Scientific Reports
Protein tyrosine phosphatase non-receptor type 13 (PTPN13) is a non-receptor protein tyrosine phosphatase with context-dependent roles as tumour suppressor or promoter.
David A. Cabrera-Riofrío, Hongbing Li, Clara García-Calvo, Carmen Sánchez-Bernal, Jesús Sánchez-Yagüe, Yigal Dror, Rubén M. Buey, Ángel Hernández-Hernández   +7 more
doaj   +1 more source

Correction: Lara-Romero et al. Phylogenetic and Molecular Analysis of the Porcine Epidemic Diarrhea Virus in Mexico during the First Reported Outbreaks (2013-2017). <i>Viruses</i> 2024, <i>16</i>, 309. [PDF]

Viruses
Lara-Romero R, Martínez-Bautista R, González-Martínez R, De la Luz-Armendáriz J, Herrera-Camacho I, Rosas-Murrieta N, Márquez-Valdelamar L, Rivera-Benítez JF.   +7 more
europepmc   +1 more source

Editorial: Genomic and metabolomic diversity in fruit plants: impacts of breeding techniques. [PDF]

Front Plant Sci
Mezzetti B, Usadel B, Osorio S.
europepmc   +1 more source