What's new? Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic precursor to multiple myeloma, sharing substantial genetic features with overt malignancy. Given evidence implicating autophagy in myeloma risk, this study examined whether genetic variations in autophagy‐related genes influence MGUS susceptibility.
José Manuel Sánchez‐Maldonado +54 more
wiley +1 more source
The Role of Natriuretic peptides in Renovascular Hypertension and its correlation with the Evolution of Myocardial Hypertrophy [PDF]
The interactions between pressure and volume overload that occur in hypertension lead to different patterns of cardiac hypertrophy and to increase in natriuretic peptides (NPs).
Cavallero, Carmen Susana +4 more
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ABSTRACT Obstructive sleep apnea (OSA), marked by intermittent hypoxia, is associated with obesity, type 2 diabetes and metabolic associated fatty liver disease. In pregnancy, it remains underdiagnosed despite links to gestational diabetes, hypertension, and foetal growth restriction.
Esther Valverde‐Perez +6 more
wiley +1 more source
Targeted mutagenesis of FaTM6 in the Octoploid Strawberry (Fragaria x ananassa) using the CRISPR/Cas9 System [PDF]
The B-class of MADS-box transcription factors has been studied in many plant species, but remain functionally uncharacterized in the Rosaceae family.
Duarte-Conde, José Antonio +2 more
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Promoter sequence of Shiga Toxin II (Stx2) is recognized in vivo leading to the production of biologically active Stx2 [PDF]
Shiga toxins (Stxs) are the main agent responsible for the development of hemolytic uremic syndrome (HUS), the most severe and life-threatening systemic complication of infection with enterohemorrhagic Escherichia coli (EHEC) strains.
Baez, Natalia Soledad +10 more
core +1 more source
The crystal structure of an Asp49 phospholipase A2 from L. muta is reported, revealing a tetrameric assembly, catalytic conservation and a polarized electrostatic surface potentially linked to membrane targeting.Snake‐venom phospholipases A2 (PLA2s) are small, structurally conserved enzymes that contribute significantly to the pathophysiology of ...
Noelia Erika Neyra Chama +9 more
wiley +1 more source
Glutamate synthases from conifers: gene structure and phylogenetic studies
Background Plants synthesize glutamate from ammonium by the combined activity of the enzymes glutamine synthetase (GS) and glutamate synthase (GOGAT) through the glutamate synthase cycle.
Ángel García-Gutiérrez +2 more
doaj +1 more source
Protein dysfunction, activity and dysactivity: studies on the the papillomavirus E7 protein by means of reverse molecular biology [PDF]
Reviso algunos conceptos aplicados a las proteínas en investigaciones biológicas de distintas escalas, tomando como ejemplo a la proteína E7 del virus del papiloma.
Sánchez Miguel, Ignacio Enrique
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Foliculogénesis Ovárica en la Raya Marmorada, Sympterygia bonapartii (Müller & Henle, 1841) (Chondrichthyes, Rajidae) [PDF]
Los Condrictios se han convertido en un recurso económico importante en las últimas décadas, siendo Argentina uno de los países que más explota tiburones y rayas, incluso a niveles que exceden los límites de varias especies.
Díaz Andrade, María Constanza +3 more
core +1 more source
La enseñanza del metabolismo: retos y oportunidades [PDF]
En el marco del Proyecto de Innovación Educativa de la Universidad de Málaga PIE15-163, cuya descripción y resultados incluimos, decidimos que esta era una excelente oportunidad para reflexionar acerca de la enseñanza del metabolismo y de poner por ...
Aldana-Montes, Jose Francisco +27 more
core +1 more source

