Results 81 to 90 of about 39,113 (232)
BiomoleculesThe 18-exon human TKFC gene codes for dual-activity triokinase and FMN cyclase (TKFC) in an ORF, spanning from exon 2 to exon 18. In addition to TKFC-coding transcripts (classified as tkfc type by their intron-17 splice), databases contain evidence for ...
María Jesús Costas +5 more
doaj +1 more source
Evaluation of metabolism and biosignaling in the angiogenic microenvironment as potential targets for therapeutic intervention [PDF]
, 2017 The "re-discovery" of Warburg effect at the turn of the present millennium has been a key determinant of the current renewed interest on cancer metabolism. In fact, metabolic reprogramming has been identified as one of the hallmarks of cancer.
Carrillo, Paloma +7 more
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British Journal of Pharmacology, Volume 183, Issue 9, Page 1993-2008, May 2026.Abstract Background and Purpose Immune tolerance prevents inflammation and autoimmunity, with dendritic cells (DCs) playing a key role. Reprogramming DCs towards a tolerogenic state represents a promising therapeutic strategy. Sulforaphane (SFN) has known immunomodulatory effects, but its clinical application is limited by poor stability and ...
María Elena Angarita‐Planchez +6 more
wiley +1 more source
Urine‐Derived iPSC Neurospheres Uncover Proteomic Correlates of Clinical Severity in Dravet Syndrome
Journal of Neurochemistry, Volume 170, Issue 5, May 2026.Urine epithelial cells from Dravet syndrome (DS) patients carrying distinct SCN1A variants were reprogrammed into induced pluripotent stem cells (iPSCs) and differentiated into neural stem cells (NSCs) to generate patient‐derived neurospheres. Three neurosphere lines were analyzed in biological triplicates using isobaric quantitative proteomics ...
Michele Martins +9 more
wiley +1 more source
GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells
AntioxidantsA pathway frequently altered in cancer is glutaminolysis, whereby glutaminase (GA) catalyzes the main step as follows: the deamidation of glutamine to form glutamate and ammonium.
Juan De los Santos-Jiménez +4 more
doaj +1 more source
Changes in P2Y Purinergic Receptor Expression in the Ciliary Body in a Murine Model of Glaucoma
Frontiers in Pharmacology, 2017 Glaucoma is a neuropathology, often accompanied by an elevated intraocular pressure (IOP), which can lead to blindness. Since DBA/2J mice develop glaucoma, several studies of the physiopathology of glaucoma have been reported in this animal model.
Begoña Fonseca +5 more
doaj +1 more source
NO3- selective mini-electrodes as a tool to investigate the NO3- traffic in Chlamydomonas reinhardtii D. [PDF]
, 2017 Ion selective NO3- mini-electrodes were used to measure the external NO3- concentration in C. reinhardtii liquid cultures. Electrodes were prepared using glass capillaries (1.5 mm external diameter).
Díaz, Jordi +4 more
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Land Degradation &Development, Volume 37, Issue 7, Page 2873-2885, 30 April 2026.ABSTRACT Lindane (γ‐hexachlorocyclohexane, γ‐HCH) is a broad‐spectrum pesticide widely used since the 1950s until its inclusion in the Stockholm Convention list of Persistent Organic Pollutants (POPs) in 2009, together with other HCH isomers. The high persistence and mismanagement of the toxic wastes generated during its synthesis have led to serious ...
Giuliana Oriana Morabito +4 more
wiley +1 more source
Insights into aging mechanisms from comparative genomics in orange and silver roughies
Scientific ReportsThe demersal fish orange roughy (Hoplostethus atlanticus) can live for up to 250 years, twenty times more than its congener silver roughy (Hoplostethus mediterraneus). Studies of Hoplostethus have focused mainly on its ecology and conservation due to its
Dido Carrero +5 more
doaj +1 more source