Results 101 to 110 of about 72,831 (298)

Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery

open access: yesAggregate, EarlyView.
This review highlights recent progress in cell membrane‐coated lipid nanoparticles (CMC‐LNPs), focusing on their design, preparation methods, functional integration, and biomedical applications. It discusses various types of LNPs and coating strategies, characterization techniques, therapeutic functions, and applications.
Moataz B. Zewail   +5 more
wiley   +1 more source

Modeling heterogeneity in large‐scale bioreactors using the method of moments with a truncated normal distribution

open access: yesAIChE Journal, EarlyView.
ABSTRACT Large‐scale bioreactors in industrial bioprocesses pose challenges due to extracellular concentration gradients and intracellular heterogeneity. This study introduces a novel approach integrating the method of moments with truncated normal distributions (MM‐TND) to model intracellular heterogeneity while maintaining computational feasibility ...
Ittisak Promma   +3 more
wiley   +1 more source

Bioreactor Development for Production of Viral Pesticides or Heterologous Proteins in Insect Cell Culturesa [PDF]

open access: bronze, 1990
Michael L. Shuler   +7 more
openalex   +1 more source

A Novel Semi‐Automated Pipeline for Optimizing 3D‐Printed Drug Formulations

open access: yesAdvanced Intelligent Systems, EarlyView.
A novel, semi‐automated deep learning and differential evolution pipeline designed for generating medicines for 3D‐printed medicines is introduced. This pipeline successfully generates a diverse range of drug formulations with an 80% printing success rate and 92% accuracy in predicting printing parameters.
Youssef Abdalla   +8 more
wiley   +1 more source

Liquid Metal Sloshing for High‐Load Active Self‐Healing System: An Application to Tendon‐Driven Legged Robot

open access: yesAdvanced Intelligent Systems, EarlyView.
Liquid metal “sloshing” by the robot's own actuator is proposed to improve the self‐healing performance. The proposed method drastically enhances the healed strength by decomposing the surface oxides and the impurities. The method contributes to the world's first demonstration of active self‐healing behavior performed by a life‐sized legged robot. Self‐
Shinsuke Nakashima   +8 more
wiley   +1 more source

Selective Phosphorylation of Phenols and Benzenediols by the Kinase PsiK and Variants Thereof

open access: yesAngewandte Chemie, EarlyView.
PsiK from Psilocybe cubensis phosphorylates a diverse set of substituted phenols and benzenediols beyond its native substrate. High‐throughput screening of active site mutant libraries using DESI‐MS enabled protein engineering of PsiK, further expanding its substrate scope.
Ahram Kim   +8 more
wiley   +2 more sources

Achieving scalable expansion of therapeutic porcine hepatocytes in vivo through serial transplantation

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This represents the first serial hepatocyte transplantation pig model designed to investigate the massive hepatocyte proliferation in vivo. Leveraging this novel model, we achieved serial hepatocyte transplantation and regeneration in a porcine model, where the transplanted hepatocytes effectively repopulated the livers of two‐generation model pigs in ...
Zhiqiang Han   +10 more
wiley   +1 more source

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