Results 1 to 10 of about 2,612 (69)

Gene Expression Space Shapes the Bioprocess Trade-Offs among Titer, Yield and Productivity

Applied Sciences, 2021
Optimal gene expression is central for the development of both bacterial expression systems for heterologous protein production, and microbial cell factories for industrial metabolite production.
Fernando N. Santos-Navarro, Yadira Boada, Alejandro Vignoni, Jesús Picó   +3 more
doaj   +1 more source

Development and Scalable Production of Newcastle Disease Virus-Vectored Vaccines for Human and Veterinary Use

Viruses, 2022
The COVID-19 pandemic has highlighted the need for efficient vaccine platforms that can rapidly be developed and manufactured on a large scale to immunize the population against emerging viruses.
Julia P. C. Fulber, Amine A. Kamen
doaj   +1 more source

Process Development for Newcastle Disease Virus-Vectored Vaccines in Serum-Free Vero Cell Suspension Cultures

Vaccines, 2021
The ongoing COVID-19 pandemic drew global attention to infectious diseases, attracting numerous resources for development of pandemic preparedness plans and vaccine platforms—technologies with robust manufacturing processes that can quickly be pivoted to
Julia Puppin Chaves Fulber, Omar Farnós, Sascha Kiesslich, Zeyu Yang, Shantoshini Dash, Leonardo Susta, Sarah K. Wootton, Amine A. Kamen   +7 more
doaj   +1 more source

Microfluidic Bioreactor Made of Cyclo-Olefin Polymer for Observing On-Chip Platelet Production

Micromachines, 2021
We previously proposed a microfluidic bioreactor with glass–Si–glass layers to evaluate the effect of the fluid force on platelet (PLT) production and fabricated a three-dimensional (3D) microchannel by combining grayscale photolithography and deep ...
Hiroki Kumon, Shinya Sakuma, Sou Nakamura, Hisataka Maruyama, Koji Eto, Fumihito Arai   +5 more
doaj   +1 more source

Enhanced Phenazine-1-Carboxamide Production in Pseudomonas chlororaphis H5△fleQ△relA through Fermentation Optimization

Fermentation, 2022
Phenazine-1-carboxamide (PCN) is effective to control many plant pathogens, and improving PCN production would be of great significance in promoting its development as a biopesticide.
Jiajia Cui, Wei Wang, Hongbo Hu, Hongyan Zhang, Xuehong Zhang   +4 more
doaj   +1 more source

Establishing a Robust Manufacturing Platform for Recombinant Veterinary Vaccines: An Adenovirus-Vector Vaccine to Control Newcastle Disease Virus Infections of Poultry in Sub-Saharan Africa

Vaccines, 2020
Developing vaccine technology platforms to respond to pandemic threats or zoonotic diseases is a worldwide high priority. The risk of infectious diseases transmitted from wildlife and domestic animals to humans makes veterinary vaccination and animal ...
Omar Farnós, Esayas Gelaye, Khaled Trabelsi, Alice Bernier, Kumar Subramani, Héla Kallel, Martha Yami, Amine A. Kamen   +7 more
doaj   +1 more source

OPTIMIZATION OF AGITATION AND INCUBATION PERIOD ON PRODUCTION OF MANNANASE BY BACILLUS VELEZENSIS NRC-1 USING BENCH-SCALE BIOREACTOR [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2012
The effect of agitation speed and incubation period on the production of mannanase enzyme by Bacillus velezensis NRC-1 using bench-scale bioreactor at 45ºC was investigated.
Tarek Mazeed
doaj   +1 more source

A Low-Tech Bioreactor System for the Enrichment and Production of Ureolytic Microbes [PDF]

Polish Journal of Microbiology, 2018
Ureolysis-driven microbially induced carbonate precipitation (MICP) has recently received attention for its potential biotechnological applications. However, information on the enrichment and production of ureolytic microbes by using bioreactor systems ...
Masataka Aoki, Takuya Noma, Hiroshi Yonemitsu, Nobuo Araki, Takashi Yamaguchi, Kazuyuki Hayashi   +5 more
doaj   +1 more source

Scale-Up of Capsular Polysaccharide Production Process by Haemophilus influenzae Type b Using k_La Criterion

Bioengineering, 2022
Polyribosyl-ribitol-phosphate (PRP) from Haemophilus influenzae type b (Hib) is an active immunizing molecule used in the production of the vaccine against H.
Omar Pillaca-Pullo, Lucas Dias Vieira, Mickie Takagi   +2 more
doaj   +1 more source

Use of Pressurized and Airlift Bioreactors for Citric Acid Production by Yarrowia lipolytica from Crude Glycerol

Fermentation, 2022
Citric acid production is generally carried out in an aqueous medium in stirred tank reactors (STR), where the solubility of oxygen is low and the oxygen demand of microbial cultures is high.
Patrícia Ferreira, Marlene Lopes, Isabel Belo   +2 more
doaj   +1 more source