Results 111 to 120 of about 46,659 (254)

Stirred tank bioreactor process for chikungunya vaccine candidate VEEV-ΔC-CHIKV. [PDF]

PLoS One
Chang T, Deng C, Xie L, Zheng Y, Zhang Y, Liu J, Fu Z, Zhang B, An Q, Tian D.   +9 more
europepmc   +1 more source

A Modular Mechanistic In Silico Model for In Vitro Transcription Process Yield and Product Quality Prediction

Biotechnology and Bioengineering, EarlyView.
ABSTRACT In vitro transcription (IVT) plays a critical role in the manufacture of mRNA vaccines and therapeutics. Optimizing mRNA yield and ensuring product quality, such as capping efficiency and integrity, are essential but mechanistically complex. This study presents a modular mechanistic model of the IVT process to advance scientific understanding ...
Keqi Wang, Keilung Choy, Eli Reiser, Jinxiang Pei, Hua Zheng, Aparajita Dasgupta, Fuqiang Cheng, Guogang Dong, Bhanu Chandra Mulukutla, Joshua Mannheimer, Carolyn Huang, Hooman Farsani, Wei Xie   +12 more
wiley   +1 more source

Scaling the manufacture of adipose tissue-derived mesenchymal stromal cells: integrated bioreactor workflows from inoculation to harvest without the need of seed train. [PDF]

BMC Biotechnol
Costa MHG, Terrasso AP, Crespo IE, Valero R, Menéndez B, Painho B, Sousa CD, Gamelas B, Tomás H, Mancheno-Corvo P, Menta R, Gugel CR, Fernández-Gómez V, Herrero-Méndez Á, Mármol IZ, Avivar-Valderas A, Pérez LM, Rosa O, Lombardo E, Serra M, Ortiz-Virumbrales M.   +20 more
europepmc   +1 more source

Nicotinamide Reverses the Warburg Effect in CHO Cell Culture

Biotechnology and Bioengineering, EarlyView.
Abstract The Warburg effect, the preferential conversion of glucose‐derived pyruvat to lactate despite available oxygen, is a key feature of Chinese hamster ovary (CHO) cell culture. Lactate accumulation in recombinant protein‐producing cell culture is an inefficient usage of glucose, as well as being deleterious to cells.
James Morrissey, Ayca Cankorur‐Cetinkaya, Luigi Grassi, Annie J. Harwood‐Stamper, Jonathan Welsh, Ryte Poskute, Kasia Kozakowska‐McDonnell, Cleo Kontoravdi   +7 more
wiley   +1 more source

Solvent-Selective Complexity Reduction of Effluent Dissolved Organic Matter for ¹H NMR Spectroscopy. [PDF]

Anal Chem
Shakeri Yekta S, Enrich Prast A, Hedenström M, Sparrman T, Šafarič L, Carraro G, Oliveira HR, Anacleto TM, Björn A, Hertkorn N.   +9 more
europepmc   +1 more source

Bioreactors for cardiac organoids

reservedI bioreattori comprendono molte delle strumentazioni necessarie per creare un ambiente favorevole alla crescita cellulare. Una delle loro applicazioni è la coltura di organoidi, strutture tridimensionali che replicano organi o tessuti nativi. Si
LIGUORO, MARIA FRANCESCA
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Horizontal Tubular Bioreactors in Biotechnology

, 2006
In this review, horizontal tubular bioreactors are discussed regarding their advantages and disadvantages compared to other bioreactor types. In horizontal tubular bioreactors medium flow is characterized by plug flow conditions that can be favorable in ...
B. Santek, S. Novak, M. Ivancic, Novak, S., Ivancic, M., Horvat, P., Maric, V., Santek, B., V. Maric, P. Horvat   +9 more
core  

Detergent Virus Inactivation in Chromatography Systems

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Detergent treatment is a widely utilized virus‐inactivation step in therapeutic protein manufacturing to safeguard products. Traditionally, this operation is performed in an incubation vessel in batch mode. In this investigation, a methodology was developed to enable virus inactivation via a post‐load, detergent‐containing wash within a bind ...
Kang Cai, Etienne Utiger, Chris Afdahl, Rayan Zamat, Jennifer Anderson, Yeldys De Armas, Gisela Ferreira   +6 more
wiley   +1 more source

The Life Cycle Assessment of Filamentous Fungi in Pharmaceutical Bioremediation and Wastewater Management: A Critical Review. [PDF]

ACS ES T Water
Dejus B, Tedoldi EL, Dejus S, Kairisa L, Rajarao GK.   +4 more
europepmc   +1 more source

Bioreactors development for gaseous substrate conversion: keys of methanation

, 2017
Bioreactors development for gaseous substrate conversion: keys of methanation.
Rafrafi, Yan, Palmade, Stéphane, Dumas, Claire, Contreras, Viviana, Delagnes, Delphine, Sperandio, Mathieu, Lefebvre, Xavier   +6 more
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