Results 121 to 130 of about 46,659 (254)

Dynamic, Unconstrained Optimization of Secreted Enzyme Production in Fed‐Batch Fermentation Using Reinforcement Learning

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Reinforcement learning (RL) has been used to control a wide range of dynamic processes, especially ones that are too complex to model well or have stochastic environmental perturbations. Fed‐batch fermentations are subject to changes in starting cell growth rates and process variations that can affect cell growth and secreted target production.
Sai Harish Uthravalli, Sakib Ferdous, J. Michael Hess, Nigel F. Reuel   +3 more
wiley   +1 more source

MUC2 shifts the metabolic profiles of commensal bacteria in defined microbial communities. [PDF]

Microbiome Res Rep
Chard E, Horvath AE, Grozis M, do Nascimento RR, Baker PRS, Gorti SKK, Proos R, Horvath TD, Engevik MA.   +8 more
europepmc   +1 more source

Numerical and Experimental Assessment of Oxygen Distribution in a Perfusion Bioreactor to Mimic the Osteochondral Niche

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Oxygen supply is a critical parameter in 3D cell cultivation using bioreactors. Since bioreactor designs often prioritise practical constraints, understanding the oxygen supply dynamics of the media is crucial for achieving either uniform or spatially controlled oxygen delivery.
Franziska Alt, Eric Langner, Hans‐Peter Wiesmann, Thomas Wallmersperger, Benjamin Kruppke   +4 more
wiley   +1 more source

Investigation of Flow Characteristics in a Stirred-Tank Bioreactor with Flexible Blades via Integrated PIV and Image Recognition. [PDF]

Bioengineering (Basel)
Xu W, Cai C, Li Z, Lu H, Yang C, Liu B.
europepmc   +1 more source

Magnetoelastic Cell Monitoring System for Evaluating the Effects of Surface Chemistry on the Performance of Mesenchymal Stem Cell Growth

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The recent clinical adoption of cell therapies has increased the need for more efficient, robust, and reproducible manufacturing technologies. Human mesenchymal stromal cells (hMSCs), a major component of the cell and immunotherapeutic market, remain challenging to manufacture at scale because they require surface attachment and are highly ...
William S. Skinner, Carolina Rivera‐Crespo, Eyerusalem A. Gebreyesus, Said Cifuentes, Samantha Tan, Tristen Douglas, Maribella Domenech‐Garcia, Keat Ghee Ong   +7 more
wiley   +1 more source

Ecotoxicological Monitoring of DSS Microorganisms and Quorum Sensing-Mediated Behavior Control over Metal Corrosion of Al, Zn and Fe. [PDF]

Toxics
Dragomir RE, Gheorghe CG, Dușescu-Vasile CM, Manta AM, Movileanu DL, Bombos D.   +5 more
europepmc   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

CFD-aided design and hydrodynamic characterization of a single-use perfusion bioreactor for high density cell culture. [PDF]

Bioresour Bioprocess
Liu Y, Gu Q, Liu Y, Xu G, Zhuang Y, Guo M, Li C.   +6 more
europepmc   +1 more source

Real‐Time Biomass Estimation in High‐Density Yeast Fermentations Using Soft Sensor Modeling

Biotechnology and Bioengineering, EarlyView.
Accurate biomass measurements, both offline and online, are essential to improve prediction and control in yeast fermentation. This study develops regression‐based predictive models to correlate offline measurements (Dry Cell Weight and OD600 from a spectrophotometer) with online OD860 probe signals to provide accurate real‐time biomass estimations and
Ana G. Del Hierro, José Luis Checa‐Barrera, Juan A. Moreno‐Cid, Eoin Casey   +3 more
wiley   +1 more source

Hypoxia-induced production of the cyclolipodepsipeptide BE-43547 by <i>Micromonospora</i> sp. RV43. [PDF]

Microbiology (Reading)
Tvilum MS, Nielsen CB, Steensgaard I, Poulsen TB, Johannsen M, Tørring T.   +5 more
europepmc   +1 more source