Results 161 to 170 of about 58,775 (305)

Bioprocess optimization of <i>Metschnikowia pulcherrima</i>: carbon source selection, nutrient ratio tuning, and environmental parameter modeling using response surface methodology. [PDF]

Biotechnol Rep (Amst)
Dinić BT, Bokulich NA, Freimoser FM, von Ah U.   +3 more
europepmc   +1 more source

Induction Temperature and Feeding Profile Shape the Partitioning Between Soluble Product and Inclusion Body Formation in Escherichia coli

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Inclusion body (IB) processes yielding the recombinant product only as IBs are long‐established in the biopharmaceutical industry. Yet, for recombinant proteins that accumulate both IBs and soluble fraction depending on the selected upstream processing (USP) strategy, the influence of process parameters on the partitioning between both forms ...
Mohamed Elshazly, Lisa Ying, Florian Gisperg, Robert Klausser, Eva Prada Brichtova, Noah Schütz, Oliver Spadiut, Julian Kopp   +7 more
wiley   +1 more source

Enrichment of Hydrogen-Oxidizing Bacteria Using a Hybrid Biological-Inorganic System Under a High CO₂ Concentration or Atmospheric Air. [PDF]

Microorganisms
He S, Wei Q, Futagami R, Kameya M, Arai H, Kobayashi H.   +5 more
europepmc   +1 more source

Batch‐to‐Batch Optimization of pH Shifts in CHO Bioreactor Operations

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Culture pH is an important operating parameter in CHO cell cultures producing mAb since it directly affects growth and specific productivity. Mathematical models can be used to optimize the magnitude and timing of pH shifts provided that they are robust to model errors.
Ali Ghodba, Zahra Negahban, Anne Richelle, Chris McCready, Valerie Ward, Luis Ricardez‐Sandoval, Hector Budman   +6 more
wiley   +1 more source

Eliminating manganese sensitivity and boosting citric acid production in Aspergillus niger through transporters manipulation. [PDF]

Microb Cell Fact
Márton A, Vandal J, Bíró V, Fekete E, Sándor E, Kovács B, Tsang A, Karaffa L.   +7 more
europepmc   +1 more source

10‐Fold Improvement in Depth Filter Capacity During Integrated Dynamic Bioprocessing (IDB) Purification Through Depth Filter Cycling and Precipitate Control Strategy

Biotechnology and Bioengineering, EarlyView.
ABSTRACT During bsAb1 purification, precipitate was formed during neutralization of the affinity capture product. This precipitate was removed before loading onto the first polishing column in the Integrated Dynamic Bioprocessing (IDB) platform.
David Scherr, Ana Kanazir, Samik Das, Nikunj Sharda, Jan Martinek, David Nellis, Michael Mollet, Jon Coffman   +7 more
wiley   +1 more source

Inventory Replenishment and Transshipment for Distributed Autologous Cell Therapy Manufacturing Networks. [PDF]

Biotechnol Bioeng
Li Z, White CC, Wang K, Wang B.
europepmc   +1 more source

A Modular Micro‐Chemostat System for High‐Throughput Continuous Cultivations

Biotechnology and Bioengineering, EarlyView.
This study presents and demonstrates a modular 12‐channel micro‐chemostat, designed to be used by Genesis, a Robot Scientist developed to automate scientific research in yeast systems biology. The bioreactor performance fulfilled the predefined requirements, and the empirical results from the biological experiments were consistent with the literature ...
Erik Y. Bjurström, Filip Kronström, Ronald S. Reiserer, David K. Schaffer, Dmitry A. Markov, John P. Wikswo, Ross D. King, Ievgeniia A. Tiukova   +7 more
wiley   +1 more source

Optimisation and Scale-Up of the Heterologous Production of the Antifungal Protein PeAfpA From Penicillium expansum in Stirred-Tank Bioreactors. [PDF]

Microb Biotechnol
de Ovalle S, Garrigues S, Gimeno-Alcañiz JV, Mercader JV, Abad-Fuentes A, Marcos JF, Manzanares P.   +6 more
europepmc   +1 more source

Scaffolding a Low‐Cost Experiential Bioreactor Module: Reducing Cognitive Load to Enhance Competency and Self‐Efficacy

Biochemistry and Molecular Biology Education, EarlyView.
ABSTRACT Low‐cost experiential modules are critical for democratizing biotechnology education, yet most undergraduates lack hands‐on experience with continuous‐culture bioreactor operations, which are fundamental to industrial bioprocessing. This study employed design‐based research across two iterative cycles (Fall 2024, n = 8; Fall 2025, n = 11) to ...
Russell K. Pirlo, Matthew Lopper, Justin C. Biffinger   +2 more
wiley   +1 more source