Results 201 to 210 of about 4,013 (240)

Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media

Molecular Pharmaceutics, 2010
A series of poorly soluble BCS class II compounds with "grease ball" characteristics were assessed for solubility and dissolution rate in biorelevant dissolution media (BDM) with the purpose of investigating which molecular structures gain most in solubility when dissolved under physiologically relevant conditions.
Jonas H, Fagerberg, Oksana, Tsinman, Na, Sun, Konstantin, Tsinman, Alex, Avdeef, Christel A S, Bergström   +5 more
openaire   +4 more sources

Online monitoring of dissolution tests using dedicated potentiometric sensors in biorelevant media

European Journal of Pharmaceutics and Biopharmaceutics, 2011
The performance of the Ion-Selective Electrode (ISE) for in vitro dissolution testing using biorelevant media was evaluated in this study. In vitro dissolution was carried out using USP apparatus 2 (paddle method) with classical and with updated biorelevant media to simulate the pre- and postprandial states.
Juenemann, Daniel, Bohets, Hugo, Ozdemir, Mahir, de Maesschalck, Roy, Vanhoutte, Koen, Peeters, Karl, Nagels, Luc, Dressman, Jennifer B.   +7 more
openaire   +5 more sources

Importance of Critical Micellar Concentration for the Prediction of Solubility Enhancement in Biorelevant Media

Molecular Pharmaceutics, 2015
This study evaluated if the intrinsic surface properties of compounds are related to the solubility enhancement (SE) typically observed in biorelevant media like fasted state simulated intestinal fluids (FaSSIF). The solubility of 51 chemically diverse compounds was measured in FaSSIF and in phosphate buffer and the surface activity parameters were ...
G, Ottaviani, S, Wendelspiess, R, Alvarez-Sánchez   +2 more
openaire   +4 more sources

Sources of dissolution variability into biorelevant media

International Journal of Pharmaceutics, 2022
Identifying sources of dissolution variation is often challenging. Biorelevant dissolution media are compositionally complex, can require multiple steps to fabricate, and are utilized across differing laboratories. The objective was to determine the contributions of location, operator, media fabrication method, day, and tablet to total dissolution ...
Raqeeb, Jamil, James E, Polli
openaire   +2 more sources

Biorelevant Dissolution Media

2021
Biorelevant dissolution media are aqueous solutions or suspensions whose composition and physicochemical characteristics closely resemble human fluids found along the different portions of the gastrointestinal tract, developed to study the solubility and/or dissolution profile of orally administered drugs in a more physiologically relevant manner.
Ruiz, María Esperanza, Talevi, Alan
openaire   +2 more sources

Understanding the interaction between Soluplus® and biorelevant media components

Colloids and Surfaces B: Biointerfaces, 2020
Soluplus® (polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer) is a solubilizing copolymer commonly applied as carrier in solid dispersions of poorly soluble drugs. This polymer is used to increase the apparent solubility of drugs with low aqueous solubility and consequently enhance drug absorption by the human gastrointestinal
Juliana Munari Oliveira Pinto, Andrés Felipe Chamorro Rengifo, Cassiana Mendes, Aline Franciane Leão, Alexandre Luis Parize, Hellen Karine Stulzer   +5 more
openaire   +2 more sources

Dissolution of solid lipid extrudates in biorelevant media

International Journal of Pharmaceutics, 2012
Solid lipid extrudates with the model drug praziquantel were produced with chemically diverse lipids and investigated regarding their dissolution behaviour in different media. The lipids used in this study were glyceryl tripalmitate, glyceryl dibehenate, glyceryl monostearate, cetyl palmitate and solid paraffin.
R, Witzleb, A, Müllertz, V-R, Kanikanti, H-J, Hamann, P, Kleinebudde   +4 more
openaire   +2 more sources

An investigation of the disintegration of tablets in biorelevant media

International Journal of Pharmaceutics, 2005
The purpose of the study was to examine the disintegration of tablets in media designed to simulate conditions pertaining in the stomach. Although many studies have been performed to determine dissolution rates in these media, little work has been undertaken on the preliminary step in dissolution, namely disintegration.
Anwar, S., Fell, J. T., Dickinson, P. A.
openaire   +3 more sources

Enhanced stability of polyacrylate-coated magnetite nanoparticles in biorelevant media

Colloids and Surfaces B: Biointerfaces, 2012
Magnetite nanoparticles (MNPs) were prepared by alkaline hydrolysis of Fe(II) and Fe(III) chlorides. Adsorption of polyacrylic acid (PAA) on MNPs was measured at pH=6.5±0.3 and I=0.01 M (NaCl) to find the optimal PAA amount for MNP stabilization under physiological conditions.
Angéla, Hajdú, Márta, Szekeres, Ildikó Y, Tóth, Rita A, Bauer, Judith, Mihály, István, Zupkó, Etelka, Tombácz   +6 more
openaire   +2 more sources

Investigation of monensin Type A medicated article dissolution profiles in biorelevant media

Journal of Veterinary Pharmacology and Therapeutics, 2020
AbstractIn the United States, a generic Type A medicated article (premix) product can gain government approval by demonstrating in vivo bioequivalence (BE) to the pioneer product in a blood level, pharmacodynamic, or clinical BE study. A biowaiver can be granted based on several criteria including solubility or a dose adjusted method.
Beverly J. Krabel, Laura B. Foust, Gary B. Fuller, Andrew J. Foss, Luke H. Garner, Robert P. Hunter   +5 more
openaire   +2 more sources