Results 211 to 220 of about 4,013 (240)

Biorelevant dissolution media: Aggregation of amphiphiles and solubility of estradiol

Journal of Pharmaceutical Sciences, 2006
Biorelevant dissolution media containing bile salt and lecithin at concentrations appropriate for fed and fasted state are useful when testing oral solid formulations of poorly water-soluble drugs. Dilution of amphiphile solutions affects the aggregation state of the amphiphiles because bile salt is partitioned between the aqueous phase and the ...
Ilardia-Arana, David, Kristensen, Henning G, Müllertz, Anette   +2 more
openaire   +3 more sources

XAS Investigation of biorelevant cobalt complexes in aqueous media

New Journal of Chemistry, 2006
Cobalt is an essential element of biological cycles involved in numerous metallobiomolecules, but it becomes a toxic element at high concentration or a radiotoxic element because of its use in the nuclear industry. “Molecular speciation” in biological media is an essential prerequisite to evaluate its chemical behaviour as well as its toxic or ...
Bresson, C., Esnouf, S., Lamouroux, C., Solari, P.-L., den Auwer, C.   +4 more
openaire   +2 more sources

Theoretical Dissolution Model of Poly-Disperse Drug Particles in Biorelevant Media

Journal of Pharmaceutical Sciences, 2008
The purpose of the present study was to construct the theoretical dissolution model of poly-disperse drug particles in biorelevant media containing bile salt/ lecithin aggregates (micelles or vesicles). The effective diffusion coefficient in the biorelevant medium and the particle size distribution of drug particles were simultaneously factored into ...
Arimichi, Okazaki, Takashi, Mano, Kiyohiko, Sugano   +2 more
openaire   +2 more sources

Biorelevant media resistant co-culture model mimicking permeability of human intestine

International Journal of Pharmaceutics, 2015
Cell culture models are currently used to predict absorption pattern of new compounds and formulations in the human gastro-intestinal tract (GIT). One major drawback is the lack of relevant apical incubation fluids allowing mimicking luminal conditions in the GIT.
Delphine, Antoine, Yann, Pellequer, Camille, Tempesta, Stefan, Lorscheidt, Bernadette, Kettel, Lana, Tamaddon, Vincent, Jannin, Frédéric, Demarne, Alf, Lamprecht, Arnaud, Béduneau   +9 more
openaire   +2 more sources

Predicting Pharmacokinetic Food Effects Using Biorelevant Solubility Media and Physiologically Based Modelling

Clinical Pharmacokinetics, 2006
Food-induced changes in gastric emptying time, gastric pH and/or intestinal fluid composition may have an impact on the pharmacokinetics of drugs. The aim of this work was to use mathematical models describing physiology in fed and fasted states together with biorelevant solubility and degradation data to simulate food effects for six compounds from ...
Hannah M, Jones, Neil, Parrott, Gerd, Ohlenbusch, Thierry, Lavé   +3 more
openaire   +2 more sources

Solubilization thermodynamics of ibuprofen in modified and classical FeSSIF biorelevant media

Journal of Molecular Liquids, 2013
Abstract Some thermodynamic information related to the transfer of ibuprofen (IBP) between aqueous systems at pH 5.0 and micellar systems, in some biorelevant media, is reported. For this purpose, the apparent solubility of IBP at different temperatures, in the modified and classical Fed State Simulated Intestinal Fluid (FeSSIF) media, at different ...
Sandra M. Gómez, Diana M. Cristancho, Fleming Martínez   +2 more
openaire   +1 more source

Photocatalytic Arylations with Diazonium Salts in Aqueous and Biorelevant Media

ChemCatChem
AbstractPerforming designed, abiotic chemical transformations in live environments represents a powerful approach to interrogate and manipulate biology, and to uncover new types of biomedical tools. Despite significant advances in the area, the list of bio‐orthogonal reactions so far available is still very short, and mainly restricted to the use of ...
Xulián Fernández‐González, Joan Miguel‐Ávila, José Luis Mascareñas, María Tomás‐Gamasa   +3 more
openaire   +1 more source

Real-time dissolution behavior of furosemide in biorelevant media as determined by UV imaging

Pharmaceutical Development and Technology, 2012
The potential of UV imaging as a new small scale flow-through dissolution testing platform and its ability to incorporate biorelevant media was tested. Furosemide was utilized as a model poorly soluble drug, and dissolution media simulating conditions in the small intestine (5/1.25 mM and 40/10 mM bile salt/phospholipid, pH 6.5) together with ...
Gordon, Sarah, Naelapää, Kaisa, Rantanen, Jukka, Selen, Arzu, Müllertz, Anette, Østergaard, Jesper   +5 more
openaire   +3 more sources

Precipitation behavior of pioglitazone on the particle surface of hydrochloride salt in biorelevant media

Journal of Pharmaceutical and Biomedical Analysis, 2018
The purpose of the present study was to investigate the precipitation of a drug on the particle surface of its salt in biorelevant media. Pioglitazone (PIO, weak base, pKa = 5.8) was used as a model drug. The crystal particles of PIO hydrochloride (PIO HCl) were immobilized between two slide glasses.
Taiga Uekusa, Kiyohiko Sugano
openaire   +2 more sources

Dissolution properties of co-amorphous drug-amino acid formulations in buffer and biorelevant media.

Die Pharmazie, 2015
Co-amorphous formulations, particularly binary drug-amino acid mixtures, have been shown to provide enhanced dissolution for poorly-soluble drugs and improved physical stability of the amorphous state. However, to date the dissolution properties (mainly intrinsic dissolution rate) of the co-amorphous formulations have been tested only in buffers and ...
Heikkinen, A. T., DeClerck, L., Löbmann, Korbinian, Grohganz, H., Rades, T., Laitinen, R.   +5 more
openaire   +2 more sources