Results 131 to 140 of about 794,439 (319)

Human Gut Bacteria and Lipidic Nanoparticles: Particle Composition Predicts Structural Transformation and Bacterial Biocompatibility

Advanced Functional Materials, EarlyView.
Lipidic nanoparticles (LNPs) were incubated with 21 gut bacteria frequently associated with the human microbiome. SAXS revealed that ∼75% of tested species induced structural transformations in monoolein LNPs, whereas phytantriol and phospholipid formulations remained unaffected.
Jonathan Caukwell, Emily L. Gulliver, Livia Salvati Manni, Frithjof Herb, Caitlin Welsh, Samuel C. Forster, Andrew J. Clulow, Wye‐Khay Fong   +7 more
wiley   +1 more source

Blood Biomarkers and Surface‐Enhanced Raman Spectroscopy for Gout: A Comprehensive Review

Advanced Functional Materials, EarlyView.
Schematic illustrating gout disease progression from asymptomatic hyperuricemia to chronic tophaceous disease, highlighting the limitations of conventional imaging and biochemical diagnostics and the potential of engineered SERS platforms for ultrasensitive blood‐based detection of urate‐related biomarkers across disease stages, with the color gradient
Isuri Perera, Chiranjeevi Kanike, Appurva Tiwari, Hongyan Wu, Larry D. Unsworth, Ben Bin Xu, Xuehua Zhang   +6 more
wiley   +1 more source

Standardized Effect Measures Informing Next‐Generation Strategies for Mechanical Stimulation in Cartilage Tissue Engineering

Advanced Healthcare Materials, EarlyView.
This systematic review quantitatively compares conventional mechanical stimulation strategies in cartilage tissue engineering across 85 heterogeneous in vitro studies. Applying standardized effect measures, meta‐analysis reveals that combined compression and shear loading optimally promotes cartilage matrix development.
Jiaqi K. Shen, Tony B. Huang, Catherine E. Davey, Elias Salzer, Gerjo J. V. M. Van Osch, Sandra J. Shefelbine, Marcus G. Pandy, Kathryn S. Stok   +7 more
wiley   +1 more source

Molecular and structural studies on proteins involved in lipid biosynthesis in plants and bacteria [PDF]

, 2002
Fatty acid synthesis in plants and most bacteria is catalysed by a type II, dissociable fatty acid synthetase, critically involving the participation of acyl-carrier protein (ACP) during synthesis and elongation reactions. This provides the substrate for
Simon, Josiah William
core  

Advances in the Molecular Modification of Microbial ω-Transaminases for Asymmetric Synthesis of Bulky Chiral Amines

Microorganisms
ω-Transaminases are biocatalysts capable of asymmetrically synthesizing high-value chiral amines through the reductive amination of carbonyl compounds, and they are ubiquitously distributed across diverse microorganisms.
Xinxing Gao, Qingming He, Hailong Chen, Wangshui Cai, Long Xu, Xin Zhang, Nianqing Zhu, Shoushuai Feng   +7 more
doaj   +1 more source

Oppositely Charged Single Enzyme Nanogels Form Versatile Coacervates for Efficient Enzyme Cascade Catalysis

Advanced Materials, EarlyView.
Oppositely charged single enzyme nanogels (SENs) phase‐separate into bi‐enzymatic coacervate microdroplets, acting as both scaffold and functional units. By tuning SEN ratios, these coacervates create specific microenvironments that enable selective small‐molecule enrichment and efficient intermediate diffusion.
Andoni Rodriguez‐Abetxuko, Nadia A. Erkamp, Neshat Moslehi, Yannick H. A. Leurs, Lars Paffen, Işil Yeşil Gür, Jana Stojanović, Hugo Brasselet, Laura van der Weel, Ulf Hanefeld, Ilja K. Voets, Jan C. M. van Hest   +11 more
wiley   +1 more source

Elucidation of gibberellin biosynthesis in bacteria reveals convergent evolution

, 2017
Gibberellins (GAs) are crucial phytohormones involved in many aspects of plant growth and development, including plant-microbe interactions, which has led to GA production by plant-associated fungi and bacteria as well. While the GA biosynthetic pathways
Trevor C Charles, Peters, R. J., Lu, X., Nagel, R., Maria Cecilia Rojas, Charles, Trevor, Hedden, Peter, Charles, T. C., Mariana Montanares, Marcassa, A., Hedden, P., Peter Hedden, Montanares, M., Rojas, M. C., Peters, Reuben, Ariana Marcassa, Montanares, Mariana, Nett, Ryan, Ryan S Nett, Xuan Lu, Rojas, Maria Cecilia, Nett, R. S., Marcassa, Ariana, Lu, Xuan, Raimund Nagel, Nagel, Raimund, Reuben J Peters   +26 more
core   +1 more source

Engineered AcrIIA5 for optogenetic control of CRISPR‐Cas9‐based genome editing

mLife
The CRISPR‐Cas9 system has been proven to be a powerful tool for gene editing in living cells and shows great potential in genetic disease treatment. Anti‐CRISPR (Acr)‐based optogenetic tools could spatiotemporally regulate the activity of CRISPR‐Cas9 ...
Qi Chen, Jia Yao, Yingfan Lu, Ruikang Qiu, Zixin Deng, Yuhui Sun   +5 more
doaj   +1 more source

A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration

Advanced Materials, EarlyView.
This project developed a smart bandage‐like patch (a microneedle array) for repairing diabetic bone damage. It intelligently senses signals from infection and inflammation, then releases its medicines in a specific, timed sequence: first an antibacterial agent, then an anti‐inflammatory agent, and finally growth factors.
Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao   +10 more
wiley   +1 more source

Iron-sulphur protein catalysed [4+2] cycloadditions in natural product biosynthesis

Nature Communications
To the best of our knowledge, enzymes that catalyse intramolecular Diels-Alder ([4+2] cycloaddition) reactions are frequently reported in natural product biosynthesis; however, no native enzymes utilising Lewis acid catalysis have been reported ...
Yu Zheng, Katsuyuki Sakai, Kohei Watanabe, Hiroshi Takagi, Yumi Sato-Shiozaki, Yuko Misumi, Yohei Miyanoiri, Genji Kurisu, Toshihiko Nogawa, Ryo Takita, Shunji Takahashi   +10 more
doaj   +1 more source