Results 121 to 130 of about 872,410 (312)

Biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya [PDF]

, 1996
This thesis describes results on the biosynthesis of fluoroacetate and 4-fluorothreonine by the bacterium Streptomyces cattleya. Exploratory (^14)C-radiolabelling experiments, designed to determine the relative incorporation of a range of metabolites ...
Amin, Muhammad Ruhul
core  

Introduction of human m6Am methyltransferase PCIF1 facilitates the biosynthesis of terpenoids in Saccharomyces cerevisiae

Microbial Cell Factories
Background The application of synthetic biology techniques has been recognized as an efficient alternative for the biosynthesis of high-value natural products, and various metabolic engineering strategies have been employed to develop microbial cell ...
Guoli Wang, Mingkai Li, Bengui Fan, Xiqin Liang, Jun Wang, Yanbing Shi, Qiusheng Zheng, Defang Li, Tianyue An   +8 more
doaj   +1 more source

Characterization of a SAM-dependent fluorinase from a latent biosynthetic pathway for fluoroacetate and 4-fluorothreonine formation in Nocardia brasiliensis [v1; ref status: indexed, http://f1000r.es/2tz]

F1000Research, 2014
Fluorination has been widely used in chemical synthesis, but is rare in nature. The only known biological fluorination scope is represented by the fl pathway from Streptomyces cattleya that produces fluoroacetate (FAc) and 4-fluorothreonine (4-FT).
Yaya Wang, Zixin Deng, Xudong Qu
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

IFIT3 promotes lymph node metastasis by interacting with LASP1 to activate FAK-ERK signaling in esophageal squamous cell carcinoma

Cell Death and Disease
Lymph node metastasis (LNM) is an important cause of poor prognosis in patients with esophageal squamous cell carcinoma (ESCC). However, the mechanism of LNM in ESCC has not been elucidated.
Qixiao Cui, Xiaolin Zhou, Xiaojie Chen, Xiaochuan Zhao, Rui Zhang, Jince Wang, Xiaoli Li, Guoli Wang, Bohan Li, Minjing Li, Jiajia Chen, Xihang Gao, Yanbing Shi, Wenting Li, Pan Hong, Defang Li   +15 more
doaj   +1 more source

Discovery and characterization of the tubercidin biosynthetic pathway from Streptomyces tubercidicus NBRC 13090

Microbial Cell Factories, 2018
Background Tubercidin (TBN), an adenosine analog with potent antimycobacteria and antitumor bioactivities, highlights an intriguing structure, in which a 7-deazapurine core is linked to the ribose moiety by an N-glycosidic bond.
Yan Liu, Rong Gong, Xiaoqin Liu, Peichao Zhang, Qi Zhang, You-Sheng Cai, Zixin Deng, Margit Winkler, Jianguo Wu, Wenqing Chen   +9 more
doaj   +1 more source

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

FEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source

Biosynthesis

, 1992
xiv,226 hal,;ill,;30 ...
Smith and Wood
core  

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source