Results 101 to 110 of about 794,439 (319)

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

The lytB gene of Escherichia coli is essential and specifies a product needed for isoprenoid biosynthesis

, 2001
LytB and GcpE, because they are codistributed with other pathway enzymes, have been predicted to catalyze unknown steps in the nonmevalonate pathway for isoprenoid biosynthesis.
McLennan, Neil, Coulson, Andrew, McAteer, Sean, Masters, Millicent/Mrs Donachie   +3 more
core  

Fluorometabolite biosynthesis in streptomyces cattleya [PDF]

, 1999
Nature has evolved the ability to form a C-F bond, as exemplified by the bacterium Streptomyces cattleya, which elaborates fluoroacetate (FAc) and 4-fluorothreomne (4- FT). The mechanism of this bond formation are unknown.
Moss, S.J., Moss, Steven J.
core  

Iridoid Sex Pheromone Biosynthesis in Aphids Mimics Iridoid‐Producing Plants

, 2021
Biosynthesis of (1R,4aS,7S,7aR)‐nepetalactol (1) and (4aS,7S,7aR)‐nepetalactone (2) in plants involves iridoid synthase (ISY), an atypical reductive cyclase that catalyses the reduction of 8‐oxogeranial into the reactive enol of (S)‐8‐oxocitronellal, and
Stockman, R. A,, Pickett, J. A., Caulfield, J. C., Neil J. Oldham, Birkett, Michael A., Oldham, Neil J., Oldham, N. J., Pickett, John A., Partridge, S., Withall, David M., Robert A. Stockman, Birkett, M. A., Partridge, Suzanne J., David M. Withall, Suzanne J. Partridge, Caulfield, John C., John C. Caulfield, Stockman, Robert A., Withall, D., John A. Pickett, Michael A. Birkett   +20 more
core   +1 more source

Efficient editing DNA regions with high sequence identity in actinomycetal genomes by a CRISPR-Cas9 system

Synthetic and Systems Biotechnology, 2019
Actinobacteria able to produce varieties of bioactive natural products have been long appreciated by the field of drug discovery and development. Recently, a few of CRISPR/Cas9 systems bearing different types of replicons (pSG5 and pIJ101) were developed
Jingjun Mo, Shuwen Wang, Wan Zhang, Chunyu Li, Zixin Deng, Lixin Zhang, Xudong Qu   +6 more
doaj   +1 more source

Biosynthesis of Lactacystin.

The Journal of Antibiotics, 1995
The biosynthesis of lactacystin, a new microbial metabolite which induces differentiation of neuroblastoma cells, was studied by the feeding experiments of various 13C-labeled compounds and NMR spectroscopic analysis. The feeding experiments showed that lactacystin consists of three containing gamma-lactam moiety arises by a condensation between ...
S, Takahashi, K, Uchida, A, Nakagawa, Y, Miyake, M, Kainosho, K, Matsuzaki, S, Omura   +6 more
openaire   +3 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Engineering and modification of microbial chassis for systems and synthetic biology

Synthetic and Systems Biotechnology, 2019
Engineering and modifying synthetic microbial chassis is one of the best ways not only to unravel the fundamental principles of life but also to enhance applications in the health, medicine, agricultural, veterinary, and food industries.
Haotian Chi, Xiaoli Wang, Yue Shao, Ying Qin, Zixin Deng, Lianrong Wang, Shi Chen   +6 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Biosynthesis-Inspired Approach to Kujounin A₂ Using a Stereoselective Tsuji–Trost Alkylation

, 2018
A new biosynthesis was proposed for the kujounins A1 and A2 beginning from ascorbic acid, which in turn inspired a synthetic approach to kujounin A2.
Alexander Burtea (4319965), Alexander Burtea, Scott D. Rychnovsky (1335972), Scott D. Rychnovsky   +3 more
core   +1 more source