Results 81 to 90 of about 900,154 (308)

Synthesis of Indenones via Persulfate Promoted Radical Alkylation/Cyclization of Biaryl Ynones with 1,4-Dihydropyridines

Molecules
The oxidative radical cascade cyclization of alkynes has emerged as a versatile strategy for the efficient construction of diverse structural units and complex molecules in organic chemistry.
Wanwan Wang, Lei Yu
doaj   +1 more source

Expression analysis of flavonoid biosynthesis genes during Arabidopsis thaliana silique and seed development with a primary focus on the proanthocyanidin biosynthetic pathway [PDF]

, 2010
Kleindt CK, Stracke R, Mehrtens F, Weisshaar B. Expression analysis of flavonoid biosynthesis genes during Arabidopsis thaliana silique and seed development with a primary focus on the proanthocyanidin biosynthetic pathway. BMC Research Notes. 2010;3(1):
Frank Mehrtens, Christiane Katja Kleindt, Bernd Weisshaar, Christiane Kleindt, Ralf Stracke, Stracke, Ralf ; https://orcid.org/, Kleindt, Christiane Katja, Mehrtens, Frank, Weisshaar, Bernd ; https://orcid.org/   +8 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Biosynthesis and metabolic engineering of natural sweeteners

AMB Express
Natural sweeteners have attracted widespread attention because they are eco-friendly, healthy, low in calories, and tasty. The demand for natural sweeteners is increasing together with the popularity of green, low-carbon, sustainable development.
Bengui Fan, Xiqin Liang, Yichi Li, Mingkai Li, Tongle Yu, Yuan Qin, Bohan Li, Tianyue An, Guoli Wang   +8 more
doaj   +1 more source

Isolation and Functional Characterization of a Gene Encoding Squalene Synthase from Amaranthus tricolor

Agronomy
Squalene, a high-value triterpenoid precursor widely used in pharmaceuticals and vaccine adjuvants, is primarily sourced from shark liver oil—an unsustainable practice that has driven interest in developing plant-based production alternatives.
Yuanfeng Lv, Xiaoyang Lin, Zaifeng Du, Guihong Qi, Yinan Yang, Yufeng Luo, Hongbo Zhang   +6 more
doaj   +1 more source

SspH, a Novel HATPase Family Regulator, Controls Antibiotic Biosynthesis in Streptomyces

, 2022
Streptomyces can produce a wealth of pharmaceutically valuable antibiotics and other bioactive compounds. Production of most antibiotics is generally low due to the rigorously controlled regulatory networks, in which global/pleiotropic and cluster ...
Xiang, Wensheng, Shanshan Li, Wang, Xiangjing, Ye, Lan, Yang, Xue, Lan Ye, Xiangjing Wang, Yanyan Zhang, Wensheng Xiang, Li, Shanshan, Zhang, Yanyan, Xue Yang   +11 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Genome mining in Trichoderma viride J1-030: discovery and identification of novel sesquiterpene synthase and its products

Beilstein Journal of Organic Chemistry, 2019
Sesquiterpene synthases in Trichoderma viride have been seldom studied, despite the efficiency of filamentous fungi for terpenoid production. Using the farnesyl diphosphate-overexpressing Saccharomyces cerevisiae platform to produce diverse terpenoids ...
Xiang Sun, You-Sheng Cai, Yujie Yuan, Guangkai Bian, Ziling Ye, Zixin Deng, Tiangang Liu   +6 more
doaj   +1 more source

Engineering and modification of microbial chassis for systems and synthetic biology

Synthetic and Systems Biotechnology, 2019
Engineering and modifying synthetic microbial chassis is one of the best ways not only to unravel the fundamental principles of life but also to enhance applications in the health, medicine, agricultural, veterinary, and food industries.
Haotian Chi, Xiaoli Wang, Yue Shao, Ying Qin, Zixin Deng, Lianrong Wang, Shi Chen   +6 more
doaj   +1 more source

Biosynthesis of Streptolidine Involved Two Unexpected IntermediatesProduced by a Dihydroxylase and a Cyclase through UnusualMechanisms

, 2014
Streptothricin-F (STT-F), one of the early-discovered antibiotics, consists of three components, a β-lysine homopolymer, an aminosugar d-gulosamine, and an unusual bicyclic streptolidine. The biosynthesis of streptolidine is a long-lasting but unresolved
Chang-Jer Wu, Kuan-Hung Lin, Jin-Yuan Ho, Ming-Daw Tsai, Chih-Chung Wu, Chin-Yuan Chang, Syue-Yi Lyu, and Tsung-Lin Li, Ning-Shian Hsu, Cheng-Fong Tang, Yu-Chen Liu   +10 more
core   +1 more source