Results 71 to 80 of about 794,439 (319)

Biosynthesis of fucoxanthin and diadinoxanthin and function of initial pathway genes in Phaeodactylum tricornutum

, 2012
The biosynthesis pathway to diadinoxanthin and fucoxanthin was elucidated in Phaeodactylum tricornutum by a combined approach involving metabolite analysis identification of gene function.
Sandmann, Gerhard, Steiger, Sabine, Büchel, Claudia, Breitenbach, Jürgen, Dambek, Michael, Eilers, Ulrike   +5 more
core   +1 more source

Mycotoxins - Their Biosynthesis in Fungi: Biosynthesis of the Trichothecenes

Journal of Food Protection, 1979
The biosynthetic pathway as currently postulated for trichothecin, a model 12,13-epoxy-Δ9-trichothecene, involves the following sequence: 3 mevalonic acids → farnesyl pyrophosphate → trichodiene → trichodiol → 12,13-epoxytrichothec-9-ene → trichodermol → 12,13-epoxy,4β, 8a-dihydroxy-trichothec-9-ene → trichothecolone → trichothecin.
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Development of Integrated Vectors with Strong Constitutive Promoters for High-Yield Antibiotic Production in Mangrove-Derived Streptomyces

Marine Drugs
It is important to improve the production of bioactive secondary products for drug development. The Escherichia coli—Streptomyces shuttle vector pSET152 and its derived vector pIB139 containing a strong constitutive promoter ermEp* are commonly used as ...
Mingxia Zhao, Zhiqiang Yang, Xinyue Li, Yaqi Liu, Yingying Zhang, Mengqian Zhang, Yangli Li, Xincheng Wang, Zixin Deng, Kui Hong, Dongqing Zhu   +10 more
doaj   +1 more source

Biosynthesis of Pectin [PDF]

Plant Physiology, 2010
The plant cell wall is composed of polysaccharides and proteins. In addition, some cells have walls impregnated with lignin. In all cases, the polysaccharides constitute the major part of the wall.
Harholt, Jesper, Suttangkakul, Anongpat, Scheller, Henrik Vibe   +2 more
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Alternative Haem Biosynthesis Pathway: Structure, Function and Properties of Sirohaem Decarboxylase [PDF]

, 2014
Haem, a cyclic tetrapyrrole, is found in organisms from all three domains of life. Haem is a prosthetic group for many proteins involved in essential biological processes such as respiration and oxygen transport.
Palmer, David James
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Functional analysis of the Lactococcus lactis galU and galE genes and their impact on sugar nucleotide and exopolysaccharide biosynthesis

, 2001
We studied the UDP-glucose pyrophosphorylase (galU) and UDP-galactose epimerase (galE) genes of Lactococcus lactis MG1363 to investigate their involvement in biosynthesis of UDP-glucose and UDP-galactose, which are precursors of glucose- and galactose ...
Boels, I.C., Vos, W.M., de, Kleerebezem, M., Ramos, A., de Vos, W.M.   +4 more
core   +1 more source

Transcriptional Response of Selenopolypeptide Genes and Selenocysteine Biosynthesis Machinery Genes in Escherichia coli during Selenite Reduction [PDF]

, 2014
This work was supported by a United States Department of Agriculture-Cooperative State Research, Education, and Extension Service grant (no. 2009-35318-05032), a Biotechnology Research grant (no.
Kittur, Farooqahmed S., Katherine H. Sun, Xie, Jiahua, Tetteh, Antonia Y., Sun, Katherine H., Ibeanu, Gordon C., Hung, Chiu-Yueh, Jiahua Xie, Chiu-Yueh Hung, Farooqahmed S. Kittur, Daniel Williams, Antonia Y. Tetteh, Gordon C. Ibeanu, Williams, Daniel   +13 more
core   +1 more source