Results 91 to 100 of about 872,410 (312)

Synthesis of Indenones via Persulfate Promoted Radical Alkylation/Cyclization of Biaryl Ynones with 1,4-Dihydropyridines

Molecules
The oxidative radical cascade cyclization of alkynes has emerged as a versatile strategy for the efficient construction of diverse structural units and complex molecules in organic chemistry.
Wanwan Wang, Lei Yu
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The biosynthesis of nojirimycins [PDF]

Streptomyces subrutilus ATCC 27467, when grown on a glucosecontaining soyabean medium, produces both 1-deoxymannonojirimycin (DMJ) and 1-deoxynojirimycin (DNJ) in its culture medium.
Hardick, David James
core  

CdsA is involved in biosynthesis of glycolipid MPIase essential for membrane protein integration in vivo [PDF]

, 2021
MPIase is a glycolipid that is involved in membrane protein integration. Despite evaluation of its functions in vitro, the lack of information on MPIase biosynthesis hampered verification of its involvement in vivo. In this study, we found that depletion
IIMURA, Naoki, KAMEMOTO, Yuki, FUJIKAWA, Kohki, ENDO, Toshiya, KURUMA, Yutetsu, TAMURA, Yasushi, NISHIKAWA, Hanako, NISHIYAMA, Ken-ichi, SAWASATO, Katsuhiro, SATO, Ryo, YAMAGUCHI, Toshiyuki, UEDA, Takuya, SHIMAMOTO, Keiko   +12 more
core  

Isolation and Functional Characterization of a Gene Encoding Squalene Synthase from Amaranthus tricolor

Agronomy
Squalene, a high-value triterpenoid precursor widely used in pharmaceuticals and vaccine adjuvants, is primarily sourced from shark liver oil—an unsustainable practice that has driven interest in developing plant-based production alternatives.
Yuanfeng Lv, Xiaoyang Lin, Zaifeng Du, Guihong Qi, Yinan Yang, Yufeng Luo, Hongbo Zhang   +6 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Elucidation of gibberellin biosynthesis in bacteria reveals convergent evolution [PDF]

, 2017
Gibberellins (GAs) are crucial phytohormones involved in many aspects of plant growth and development, including plant-microbe interactions, which has led to GA production by plant-associated fungi and bacteria as well. While the GA biosynthetic pathways
Trevor C Charles, Peters, R. J., Lu, X., Nagel, R., Maria Cecilia Rojas, Charles, Trevor, Hedden, Peter, Charles, T. C., Mariana Montanares, Marcassa, A., Hedden, P., Peter Hedden, Montanares, M., Rojas, M. C., Peters, Reuben, Ariana Marcassa, Montanares, Mariana, Nett, Ryan, Ryan S Nett, Xuan Lu, Rojas, Maria Cecilia, Nett, R. S., Marcassa, Ariana, Lu, Xuan, Raimund Nagel, Nagel, Raimund, Reuben J Peters   +26 more
core   +1 more source

Engineering and modification of microbial chassis for systems and synthetic biology

Synthetic and Systems Biotechnology, 2019
Engineering and modifying synthetic microbial chassis is one of the best ways not only to unravel the fundamental principles of life but also to enhance applications in the health, medicine, agricultural, veterinary, and food industries.
Haotian Chi, Xiaoli Wang, Yue Shao, Ying Qin, Zixin Deng, Lianrong Wang, Shi Chen   +6 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Fluorometabolite biosynthesis in streptomyces cattleya [PDF]

, 1999
Nature has evolved the ability to form a C-F bond, as exemplified by the bacterium Streptomyces cattleya, which elaborates fluoroacetate (FAc) and 4-fluorothreomne (4- FT). The mechanism of this bond formation are unknown.
Moss, S.J., Moss, Steven J.
core