Results 71 to 80 of about 1,266,322 (341)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

The TriForC database : a comprehensive up-to-date resource of plant triterpene biosynthesis [PDF]

, 2018
Triterpenes constitute a large and important class of plant natural products with diverse structures and functions. Their biological roles range from membrane structural components over plant hormones to specialized plant defence compounds.
Bak, Soren, Botzki, Alexander, Coppens, Frederik, De Bo, Christof, Goossens, Alain, Iñigo, Sabrina, Kreft, Lukasz, Miettinen, Karel, Pollier, Jacob   +8 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Cytochrome P450-catalyzed allylic oxidation of pentalenene to 1-deoxypentalenic acid in pentalenolactone biosynthesis

Engineering Microbiology
Pentalenolactone is a sesquiterpene antibiotic from Streptomyces. Its biosynthetic pathway has been elucidated, except for the oxidation of pentalen-13-al to 1-deoxypentalenic acid.
Jing Li, Chengde Zhang, Shiwen Wu, Jiao Xue, Ke Chen, Zixin Deng, Dongqing Zhu   +6 more
doaj   +1 more source

ttl mutants are impaired in cellulose biosynthesis under osmotic stress [PDF]

, 2018
As sessile organisms, plants require mechanisms to sense and respond to the challenging environment, that encompass both biotic and abiotic factors that results in differential development.
Amorim-Silva, Vitor, Botella-Mesa, Miguel Angel, Castillo-Garriga, Araceli, García-Moreno, Álvaro, Jaillais, Yvon, Macho, Alberto, Valpuesta-Fernandez, Victoriano   +6 more
core  

Does abscisic acid affect strigolactone biosynthesis? [PDF]

, 2010
Strigolactones are considered a novel class of plant hormones that, in addition to their endogenous signalling function, are exuded into the rhizosphere acting as a signal to stimulate hyphal branching of arbuscular mycorrhizal (AM) fungi and germination
Adie, Akiyama, Alder, Andrew J. Thompson, Anna K. Undas, Aroca, Auldridge, Bainbridge, Bethke, Booker, Booker, Bouwmeester, Bouwmeester, Burbidge, Carbone, Carolien Ruyter-Spira, Christmann, Cook, Cornish, Cutler, Davies, De Smet, Dunlap, Ejeta, Francel Verstappen, Fraser, Gomez-Roldan, Harrison, Harro Bouwmeester, Hernandez, Herrera-Medina, Jeschke, Jiang, Juan A. López-Ráez, Kahn, Kitahata, Li, Livak, López-Ráez, López-Ráez, López-Ráez, López-Ráez, Martin J. Sergeant, Matusova, Misson, Nitsch, Parry, Parry, Paszkowski, Patrick Mulder, Rani, Rock, Sagi, Saika, Schwartz, Schwartz, Schwartz, Sergeant, Simkin, Sorefan, Spinsanti, Strack, Sun, Tan, Tatsiana Charnikhova, Taylor, Taylor, Thompson, Thompson, Timothy D. H. Bugg, Umehara, Vogel, Wasaki, Wouter Kohlen, Yoneyama, Yoneyama, Zeevaart   +76 more
core   +4 more sources

Mycotoxins - Their Biosynthesis in Fungi: Biosynthesis of the Trichothecenes

Journal of Food Protection, 1979
The biosynthetic pathway as currently postulated for trichothecin, a model 12,13-epoxy-Δ9-trichothecene, involves the following sequence: 3 mevalonic acids → farnesyl pyrophosphate → trichodiene → trichodiol → 12,13-epoxytrichothec-9-ene → trichodermol → 12,13-epoxy,4β, 8a-dihydroxy-trichothec-9-ene → trichothecolone → trichothecin.
openaire   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source