Results 81 to 90 of about 1,499,955 (388)

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Optimization of nitrogen source supply for enhanced biosynthesis and quality of poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) by extremely halophilic archaeon Haloferax mediterranei

MicrobiologyOpen, 2020
The extreme halophilic archaeon, Haloferax mediterranei can accumulate polyhydroxyalkanoate (PHA) from different renewable resources. To enhance the biosynthesis and quality of PHA, H.
Diya Alsafadi, Othman Al‐Mashaqbeh, Aya Mansour, Majd Alsaad   +3 more
doaj   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Cytochrome P450-catalyzed allylic oxidation of pentalenene to 1-deoxypentalenic acid in pentalenolactone biosynthesis

Engineering Microbiology
Pentalenolactone is a sesquiterpene antibiotic from Streptomyces. Its biosynthetic pathway has been elucidated, except for the oxidation of pentalen-13-al to 1-deoxypentalenic acid.
Jing Li, Chengde Zhang, Shiwen Wu, Jiao Xue, Ke Chen, Zixin Deng, Dongqing Zhu   +6 more
doaj   +1 more source

Signature Arsenic Detoxification Pathways in Halomonas sp. Strain GFAJ-1

mBio, 2018
Since the original report that Halomonas sp. strain GFAJ-1 was capable of using arsenic instead of phosphorus to sustain growth, additional studies have been conducted, and GFAJ-1 is now considered a highly arsenic-resistant but phosphorus-dependent ...
Shuangju Wu, Lianrong Wang, Rui Gan, Tong Tong, Hao Bian, Zhiqiang Li, Shiming Du, Zixin Deng, Shi Chen   +8 more
doaj   +1 more source

The TriForC database : a comprehensive up-to-date resource of plant triterpene biosynthesis [PDF]

, 2018
Triterpenes constitute a large and important class of plant natural products with diverse structures and functions. Their biological roles range from membrane structural components over plant hormones to specialized plant defence compounds.
Bak, Soren, Botzki, Alexander, Coppens, Frederik, De Bo, Christof, Goossens, Alain, Iñigo, Sabrina, Kreft, Lukasz, Miettinen, Karel, Pollier, Jacob   +8 more
core   +2 more sources

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

ttl mutants are impaired in cellulose biosynthesis under osmotic stress [PDF]

, 2018
As sessile organisms, plants require mechanisms to sense and respond to the challenging environment, that encompass both biotic and abiotic factors that results in differential development.
Amorim-Silva, Vitor, Botella-Mesa, Miguel Angel, Castillo-Garriga, Araceli, García-Moreno, Álvaro, Jaillais, Yvon, Macho, Alberto, Valpuesta-Fernandez, Victoriano   +6 more
core  

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

THE BIOSYNTHESIS OF SUCROSE

Journal of Biological Chemistry, 1955
The enzyme, which was named sucrose phosphorylase, has not been found in plant tissues (4), and thus the mechanism of sucrose synthesis remains obscure. Evidence obtained from tracer experiments led Buchanan et al. (5, 6) to assume that in plants sucrose phosphate is formed from UDPG’ and fructose-l-phosphate.
Cardini, Carlos E., Leloir, Luis Federico, Chiriboga J.   +2 more
openaire   +3 more sources