Results 81 to 90 of about 1,154,632 (142)

The accumulation of orotic acid by a pyrimidineless mutant of Neurospora [PDF]

, 1948
The discovery of orotic acid (1,2-carboxyuracil) in cow's milk by Biscaro and Belloni (1), followed by its identification and synthesis (2-4), led to a number of speculations as to its biological origin and significance (,3,5,6).
Houlahan, Mary B., Mitchell, Herschel K., Nyc, Joseph F.   +2 more
core  

Advances in the Molecular Modification of Microbial ω-Transaminases for Asymmetric Synthesis of Bulky Chiral Amines

Microorganisms
ω-Transaminases are biocatalysts capable of asymmetrically synthesizing high-value chiral amines through the reductive amination of carbonyl compounds, and they are ubiquitously distributed across diverse microorganisms.
Xinxing Gao, Qingming He, Hailong Chen, Wangshui Cai, Long Xu, Xin Zhang, Nianqing Zhu, Shoushuai Feng   +7 more
doaj   +1 more source

Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence. [PDF]

, 2019
Although aging is considered to be an unavoidable event, recent experimental evidence suggests that the process can be counteracted. Intracellular calcium (Ca2+i) dyshomeostasis, mitochondrial dysfunction, oxidative stress, and lipid dysregulation are ...
Bomba, Manuela, Castelli, Vanessa, Cicalini, Ilaria, Cimini, Annamaria, d'Aurora, Marco, Del Boccio, Piero, Gatta, Valentina, Granzotto, Alberto, Massetti, Noemi, Navarra, Riccardo, Onofrj, Marco, Piomelli, Daniele, Sensi, Stefano L   +12 more
core  

Iron-sulphur protein catalysed [4+2] cycloadditions in natural product biosynthesis

Nature Communications
To the best of our knowledge, enzymes that catalyse intramolecular Diels-Alder ([4+2] cycloaddition) reactions are frequently reported in natural product biosynthesis; however, no native enzymes utilising Lewis acid catalysis have been reported ...
Yu Zheng, Katsuyuki Sakai, Kohei Watanabe, Hiroshi Takagi, Yumi Sato-Shiozaki, Yuko Misumi, Yohei Miyanoiri, Genji Kurisu, Toshihiko Nogawa, Ryo Takita, Shunji Takahashi   +10 more
doaj   +1 more source

Analysing a Group of Homologous BAHD Enzymes Provides Insights into the Evolutionary Transition of Rosmarinic Acid Synthases from Hydroxycinnamoyl-CoA:Shikimate/Quinate Hydroxycinnamoyl Transferases

Plants
The interplay of various enzymes and compounds gives rise to the intricate secondary metabolic networks observed today. However, the current understanding of their formation and expansion remains limited. BAHD acyltransferases play important roles in the
Jiali Zhou, Xiaofang Zou, Zixin Deng, Lian Duan   +3 more
doaj   +1 more source

Deep Learning-Based Self-Adaptive Evolution of Enzymes

Pharmaceutical Fronts
Biocatalysis has been widely used to prepare drug leads and intermediates. Enzymatic synthesis has advantages, mainly in terms of strict chirality and regional selectivity compared with chemical methods.
Shuiqin Jiang, Dong Yi
doaj   +1 more source

Thiamine Acquisition Strategies Impact Metabolism and Competition in the Gut Microbe Bacteroides thetaiotaomicron. [PDF]

, 2017
Thiamine (vitamin B1) is an essential cofactor for all organisms. Humans primarily acquire thiamine through their diet, and thiamine deficiencies have adverse neurological effects.
Costliow, Zachary A, Degnan, Patrick H
core  

Metabolic channeling of phe for lignin biosynthesis in maritime pine [PDF]

, 2017
Phenylalanine (Phe) is the main precursor of phenylpropanoids biosynthesis in plants. This vast family of Phe-derived compounds can represent more than 30% of captured photosynthetic carbon, playing essential roles in plants such as cell wall components,
Canlet, Francis, Canovas-Ramos, Francisco Miguel, De la Torre, Fernando, Debille, Sandrine, El-Azaz Ciudad, Jorge, Pascual, MB, Trontin, J-F, Álvarez-Mena, Ana, Ávila, Concepción   +8 more
core  

Deciphering small molecules as new virulence factors in the bacterial sugarcane pathogen Xanthomonas albilineans [PDF]

, 2010
Xanthomonas albilineans is a xylem-invading plant pathogen that causes leaf scald disease of sugarcane. Unlike most plant pathogenic bacteria, X. albilineans does not possess a Hrp-Type Three Secretion System. Pathogenicity of this bacterial species must
Cociancich, Stéphane, Duplan, Sandrine, Marguerettaz, Mélanie, Nachtigal, Jonny, Pieretti, Isabelle, Rott, Philippe, Royer, Monique, Süssmuth, Roderich   +7 more
core  

Integrative metabolomic and transcriptomic analyses reveal flavonoid biosynthesis pathway in Eupatorium lindleyanum. [PDF]

Sci Rep
Wang Y, Wu J, Zhou M, Yang X, Niu Y, Guo K.   +5 more
europepmc   +1 more source