Results 151 to 160 of about 202,591 (301)

The Transcriptional Architecture of Bacterial Biosynthetic Gene Clusters

Journal of Natural Products
Abstract Bacteria produce diverse bioactive metabolites with ecological and pharmaceutical importance. These compounds are synthesized by biosynthetic gene clusters (BGCs), whose expression is tightly regulated. While many studies have examined the factors influencing BGC expression, including transcription factors (TFs) and ...
Ribeiro Monteiro, Silvia, Kerdel, Yasmine, Gathot, Julianne, Rigali, Sébastien   +3 more
openaire   +3 more sources

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

eQTL Meta‐Analysis Reveals Conserved and Population‐Specific Regulatory Variation Underlying Nutritional Trait Evolution and Domestication in Tomato

Advanced Science, EarlyView.
A comprehensive meta‐analysis of expression quantitative trait loci (eQTLs) across five diverse tomato populations reveals a high‐resolution atlas of transcriptional regulation and uncovers conserved and population‐specific regulatory architectures underlying fruit nutritional quality traits, including flavonoids, sugars, organic acids, carotenoids ...
Jiantao Zhao, Xin Wang, Jing Zhang, Ryan McQuinn, Je Min Lee, Itay Gonda, Ari Feder, Yimin Xu, Baike Wang, Qinghui Yu, Denise M. Tieman, Sanwen Huang, Harry Klee, James J. Giovannoni, Zhangjun Fei   +14 more
wiley   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration [PDF]

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine.
Aguilar, C., Donahey, M. S. C., Teufel, R., Medema, M. H., Huynh, T., Jing, J., Katsuyama, Y., Zimmermann, C., Mahmud, T., Jayachandran, S., Streiff, A. B., Hooft, J. J. V. D., Barbieri, H. B., Macias, M. I., Liu, J., Santos-Medellin, C., Linington, R. G., Parra, J., Witte, T. E., Aleti, G., Augustijn, H. E., Barbosa, J. C. J., Koetsier, R. A., Borriss, R., Bulcock, B. W., Ryu, B., Bernaldo-Aguero, J., Creamer, K. E., Ostash, B. O., Tarnowski, M. J., Rubio, M. P., Kim, G. J., Hanif, N., Grayson, N. E., Bozhuyuk, K. A., Hindra, H., Kalkreuter, E., Kim, H., Rutz, A., Kakumu, Y., Li, S., Carrion, V. J., Choi, H., Barra, L., Larsen, N. J., Pham, H. T., Duncan, K. R., Damiani, T., Krug, D., Navarro, J., Robinson, S. L., Bhatt, K. M., Saldanha, M., Rosas-Becerra, L. R., Kollten, C., Gutierrez-Garcia, K., Haslinger, K., Ramesh, S., Singh, G., Connolly, J. A., Rojo, M. Y. A., Otani, H., Cumsille, A., Warnasinghe, R., Williams, S. E., Hoing, L., Korenskaia, A., Licona-Cassani, C., Merrild, A., Le, N., Singh, H., Kubach, N., Cano-Prieto, C., Rey, T., Kust, A., Reher, R., Zimmer, L., Gu, W., Strüder, A., Tan, B., Sowa, S. T., Truman, A. W., Doering, D. T., Chromy, J., Parade, D. S., Rosiles, P. Y., Salvi, L., Borges, R. M., Charria-Giron, E., Kang, K. B., Jenner, M., Sieber, S., Fewer, D. P., Tugizimana, F., Guerra, S., Machushynets, N. V., Torring, T., Yu, J., Paliya, S., Cediel-Becerra, J. D., Shah, A. D., Park, J., Lopez, J. A. V., Libis, V., Müller, A. V., Weber, T., Nguyen, G., Yang, D., Castro-Falcon, G., Dillen, J., Jung, J. J., Schoellhorn, S. M., Szenei, J., Ulbricht, C., Durusu, S., Singh, K. S., Yamada, K., Trindade, M., Frediansyah, A., Bielinski, V. A., Sokolova, N., Niedermeyer, T. H. J., Pan, X., Lorio, M., Flores, S. G., Weddeling, H. G., Hart, L., Surup, F., Cruz, A. A., Selem, N., Lee, B. T., Ossowicki, A., Kushnareva, A. K., Morgan, K. D., Kriukova, Y., Barrett, S. E., Kim, W., Gurevich, A., Rasmussen, M. H., Gavriilidou, A., Beemelmanns, C., Holland, D. C., Chooi, Y. H., Steffen, K., Sala, G. D., Foldi, J., Carter, R. S., Beqaj, D., Klapper, M., Wezel, G. P. V., Zdouc, M. M., Al-Salihi, S. A., Phan, C., Li, Y., Dallery, J., Launay, A. P., Owen, C., Winter, J. M., Schumm, C., Avelar-Rivas, J. A., Kruijff, M. D., Dommaraju, S. R., McBride, C. M., Chagas, F. O., Metsä-Ketela, M., Alharthi, S. A., Mantri, S., Alberti, F., Philmus, B., Hu, J., Helfrich, E. J., Bretscher, K. M., Fetter, A., Pidot, S. J., Gonzalez-Salazar, L. A., Piel, J., Lev, K. L., Bailey, C. B., Reitz, Z. L., Brigham, M. W., Blin, K., Larralde, M., McLellan, R. M., Arishi, A. A., Feuermann, M., Crusemann, M., Romero-Otero, A., Maleckis, M., Lien, A., Hrab, P., Booth, T. J., Jeong, E., Loureiro, C., Hemmann, J. L., Sonnenschein, E. C., Greco, C., Mast, Y., Biermann1, F., Berger, T., Buedenbender, L., Shishido, T. K., Lamber, J., Padva, L., Panghal, M., Damas-Ramos, L. C., Martin, B. D., Terlouw1, B. R., D’Agostino, P. M., Gomez-Escribano, J. P., Gentile, A., Mitchell, D. A., Williams, K., Breitenbach, M., Castelo-Branco, R., Capela, J., Kang, S., Rocca, S. M. W., Faussurier, B., Bader, C. D., Stegmann, E., Segato, L. G. B., Kovacs, A. T., Ortega, L. R. T., Lund, G., Bettenbuhl, S. M., Udwary, D. W., Axt, K. K., Martinez-Martinez, A. M., Hebra, T., Rice, A. J., Baunach, M., Sahadeo, L., Rond, T. D., Gomez, J. E. G., Tagirdzhanov, A., Sbaraini, N., Chaudhry, V., Rego, A., Sánchez-Carvajal, E., Chevrette, M. G., Maximo, M. F., Zhou, Z., Holme, J. E., Ulanova, D., Louwen, N. L., Charlop-Powers, Z., Walmsley, M., Collemare, J., Choi, Y., Gerke, J., Pourmohsenin, B., Ellerhorst, M., Gerstmans, H., Svenningsen, T., Sehnal, L., Horch, T., He, B., Rigolet, A., Kunjapur, A. M., O’Hare, J. H., Weir, A. N., Silviani, V., Choupannejad, R., Melkonian, C., Sosio, M., Tvilum, M., Vader, L., Akiyama, D. Y., Garza, E. A., Zimmermann, A., Avalon, N. E., Tong, Y., Rakhmanov, M., Kim, H. U., Ziemert, N., Lacovelli, R., Thome, N. U., Nguyen, H. T., Lftime, D., Egbert, S., Chaudhri, A. A., Pup, E. D., Lebeer, S., Lee, K., Sweeney, D., Alanjary, M., Hwang, J.   +286 more
core   +1 more source

Functional in vitro and in vivo analysis of biosynthetic genes by heterologous expression in E. coli. [PDF]

STAR Protoc, 2023
Kramer JC, Böhringer N, Mettal U, Schäberle TF.   +3 more
europepmc   +1 more source

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source