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Targeting Fumonisin Biosynthetic Genes
2016The fungus Fusarium is an agricultural problem because it can cause disease on most crop plants and can contaminate crops with mycotoxins. There is considerable variation in the presence/absence and genomic location of gene clusters responsible for synthesis of mycotoxins and other secondary metabolites among species of Fusarium.
Robert H, Proctor, Martha M, Vaughan
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Targeting Other Mycotoxin Biosynthetic Genes
2016Real-time PCR (qPCR) methods are adequate tools for sensitive and rapid detection and quantification of toxigenic molds contaminating food commodities. Methods of qPCR for quantifying zearalenone (ZEA)-, sterigmatocystin (ST)-, cyclopiazonic acid (CPA)-, and patulin (PAT)-producing molds have been designed on the basis of specific target genes involved
María J, Andrade +3 more
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Regulation of epidermin biosynthetic genes by EpiQ
Molecular Microbiology, 1993SummaryWe investigated the role of epiQ in the biosynthesis of the lantibiotic epidermin. epiQ was essential for epidermin production. It was shown that EpiQ controls epidermin production by transcriptionally activating the epiA promoter, used for transcription of most of the epidermin biosynthetic genes.
A, Peschel +4 more
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Lessons from the rifamycin biosynthetic gene cluster
Current Opinion in Chemical Biology, 1999There is currently intense interest in unravelling the modus operandi of type I modular polyketide synthases in order to lay the ground work for their use in the combinatorial biosynthesis of new bioactive molecules. Much of our knowledge is derived from studies on 6-deoxyerythronolide B (DEBS), the enzyme assembling the polyketide backbone of ...
H G, Floss, T W, Yu
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Transcriptional regulation of yeast phospholipid biosynthetic genes
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2007The last several years have been witness to significant developments in understanding transcriptional regulation of the yeast phospholipid structural genes. The response of most phospholipid structural genes to inositol is now understood on a mechanistic level. The roles of specific activators and repressors are also well established.
Meng, Chen +2 more
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Characterization of the Actinonin Biosynthetic Gene Cluster
ChemBioChem, 2018AbstractThe hydroxamate moiety of the natural product actinonin mediates inhibition of metalloproteinases because of its chelating properties towards divalent cations in the active site of those enzymes. Owing to its antimicrobial activity, actinonin has served as a lead compound for the development of new antibiotic drug candidates.
Felix Wolf +5 more
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The tylosin-biosynthetic genes of Streptomyces fradiae
Antonie van Leeuwenhoek, 2001The tylosin-biosynthetic (tyl) gene cluster occupies about 1% of the genome of Streptomycesfradiae and includes at least 43 open reading frames. In addition to structural genes required for tylosin production, the tyl cluster contains three resistance determinants and several regulatory genes.
E, Cundliffe +5 more
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Maize Methods—Starch Biosynthetic Genes
1994Starch biosynthetic genes are of interest to maize biologists for a number of reasons. These genes have been used to follow chromosomal behavior during endosperm development, as traps for transposable elements and other mutations, and as marker genes to follow tissue-specific patterns of expression.
L. Curtis Hannah +3 more
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A gene cluster of the ochratoxin A biosynthetic genes inPenicillium
Mycotoxin Research, 2006A putative ochratoxin A (OTA) biosynthetic gene cluster inP. nordicum has been identified. The first part of the gene cluster is located on a DNA fragment of 10 kb in length and harbours three genes. A gene with high homology to an alkaline serine protease gene (accession number AY557343), which represents the upstream border of the cluster ...
R, Geisen +2 more
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