Results 121 to 130 of about 202,591 (301)

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

A Novel Neotropical Bacillus siamensis Strain Inhibits Soil-Borne Plant Pathogens and Promotes Soybean Growth

Microorganisms
Soil-borne fungal pathogens such as Sclerotium spp., Rhizoctonia spp., and Macrophomina spp. pose significant threats to global agriculture, with soybean crops among the most severely affected due to damping-off disease. These pathogens cause substantial
Rodrigo F. Moreira, Elizabeth B. E. Pires, Odaiza F. Sousa, Giselly B. Alves, Luis O. Viteri Jumbo, Gil R. Santos, Luís J. Maia, Bergmann M. Ribeiro, Guy Smagghe, Elvio H. B. Perino, Rudolf Hausmann, Eugenio E. Oliveira, Raimundo W. S. Aguiar   +12 more
doaj   +1 more source

Characterization of the promoter region of biosynthetic enzyme genes involved in berberine biosynthesis in Coptis japonica

Frontiers in Plant Science, 2016
The presence of alkaloids is rather specific to certain plant species. However, berberine, an isoquinoline alkaloid, is relatively broadly distributed in the plant kingdom.
Yasuyuki Yamada, Tadashi Yoshimoto, Sayumi Tshushima Yoshida, Fumihiko Sato   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The dynamic architecture of the metabolic switch in Streptomyces coelicolor [PDF]

, 2010
BACKGROUND: During the lifetime of a fermenter culture, the soil bacterium S. coelicolor undergoes a major metabolic switch from exponential growth to antibiotic production.
Håvard Sletta, Rand, D., Hodgson, David A.,, Nentwich, Merle, Rodríguez-García, Antonio,, Moore, Joe, Herbig, A., Martín, Juan Francisco, Gregory L Challis, Rand, DA, Ellingsen, Trond E., Sletta, H., William H Gaze, Bruheim, P, Wild, D., Trond E Ellingsen, Hodgson, D. A., Battke, F., Bonin, Michael,, Legaie, R, Miguel A Juarez-Hermosillo, Challis, GL, Wild, David L.,, Merlo, M.E., Jansen, R.C., Challis, Gregory L, Ellingsen, Trond E, Wild, DL, Gaze, William H, Wild, David L, Challis, G., Challis, G.L., Øyvind M Jakobsen, Florian Battke, Burroughs, Nigel J.,, Gaze, W.H., Breitling, R., Juarez-Hermosillo, MA, Wentzel, Alexander, Rand, D. A. (David A.), Moore, J., Morrisey, E.R., Herbig, Alexander,, Iqbal, Mudassar,, Hodgson, David A, Wellington, EMH, Merlo, Maria E.,, Rand, David A, Wellington, E., Battke, Florian, Wild, David L., Alam, Mohammad T.,, Wolfgang Wohlleben, Rainer Breitling, Gaze, William H., Ritsert C Jansen, Smith, Margaret C.M.,, Wellington, E.M.H., Mudassar Iqbal, Burroughs, Nigel John, Takano, Eriko, Juarez-Hermosillo, M., Alexander Herbig, Reuther, J., Morrissey, E., Rodriguez-Garcia, A., Bonin, M, Jakobsen, Øyvind M.,, Thomas, L., Nigel J Burroughs, Martín, Juan F.,, Wohlleben, Wolfgang, Rodríguez-García, Antonio, Morrissey, Edward R.,, Breitling, Rainer,, Nentwich, Merle,, Smith, Margaret C M, Martin, J.F., Breitling, R, Ellingsen, T., Kay Nieselt, Omara, W., Walid AM Omara, Battke, Florian,, Merlo, Maria E, David L Wild, Hodgson, David A., Herbig, Alexander, Legaie, Roxane,, Ellingsen, TE, Nieselt, K, Smith, Margaret C. M., Jansen, Ritsert C., Merle Nentwich, Iqbal, M., Morrissey, Edward R., Morrissey, Edward R, Alam, MT, Bruheim, Per,, Elizabeth MH Wellington, Omara, Walid A. M., David A Hodgson, Jansen, R., Alam, M., Challis, Gregory L.,, Gaze, W., Jakobsen, Øyvind M., Wentzel, A., Martín, Juan F, Thomas, Louise, Rand, D. A., Omara, WAM, Smith, M.C.M., Morrissey, ER, Jakobsen, ØM, Takano, E., Gaze, WH, Morrisey, E.R, Rand, D.A., Iqbal, M, Challis, Gregory L., Wellington, Elizabeth M.H.,, Edward R Morrissey, Gaze, William H.,, Jansen, RC, Thomas, L, Merlo, Maria E.; id_orcid, Nieselt, Kay, Maria E Merlo, Burroughs, N., Smith, MCM, Juarez-Hermosillo, Miguel A., Moore, J, Moore, Jonathan D., Juárez, Miguel A., Jens Reuther, Merlo, ME, Nentwich, M, Louise Thomas, Juarez-Hermosillo, M.A., Reuther, J, Hodgson, DA, Jonathan Moore, Hodgson, D., Rand, David A., Omara, Walid A M, Burroughs, NJ, Reuther, Jens, Hodgson, D. A. (David A.), Bruheim, P., Jakobsen, Oyvind M., Jansen, Ritsert C, David A Rand, Sletta, Håvard, Rand, David A.,, Margaret CM Smith, Herbig, A, Lubbert Dijkhuizen, Sletta, H, Burroughs, Nigel J, Merlo, M., Martin, J., Alam, M.T., Moore, Jonathan, Smith, M., Ellingsen, Trond E.,, Moore, Jonathan,, Nieselt, K., Omara, W.A.M., Wellington, E. M. H., Alam, Mohammad Tauqee, Wentzel, Alexander,, Martín, Juan F., Merlo, Maria E., Wellington, Elizabeth M H, Dijkhuizen, Lubbert; id_orcid, Jakobsen, O., Eriko Takano, Takano, Eriko,, Juarez-Hermosillo, Miguel A, Bruheim, Per, Wohlleben, Wolfgang,, Wohlleben, W, Jansen, Ritsert C.,, Jakobsen, O.M., Roxane Legaie, Alam, Mohammad T., Battke, F, Wentzel, A, Ellingsen, T.E., Rodríguez-García, A, Breitling, Rainer, Omara, Walid A.M.,, Wild, D.L., Legaie, Roxane, Nentwich, M., Reuther, Jens,, Michael Bonin, Nieselt, Kay,, Dijkhuizen, L, Thomas, Louise,, Kay Nieselt, Per Bruheim, Mohammad T Alam, Juan F Martín, Dijkhuizen, L., Hodgson, D.A., Alexander Wentzel, Takano, E, Wohlleben, W., Bonin, Michael, Martín, JF, Legaie, R., Dijkhuizen, Lubbert, Dijkhuizen, Lubbert,, Wellington, Elizabeth M. H., Iqbal, Mudassar, Burroughs, Nigel J., Jakobsen, Øyvind M, Bonin, M., Burroughs, N.J., Sletta, Håvard,, Antonio Rodríguez-García, Juarez-Hermosillo, Miguel A.,, Takano, Eriko; id_orcid, Alam, M F   +225 more
core   +1 more source

Comparative transcriptomics of mountain pine beetle pheromone-biosynthetic tissues and functional analysis of CYP6DE3

BMC Genomics, 2017
Background The mountain pine beetle (MPB, Dendroctonus ponderosae Hopkins) is a highly destructive pest of pine forests in western North America. During flight to a new host tree and initiation of feeding, mountain pine beetles release aggregation ...
J. A. Nadeau, J. Petereit, R. L. Tillett, K. Jung, M. Fotoohi, M. MacLean, S. Young, K. Schlauch, G. J. Blomquist, C. Tittiger   +9 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Riboflavin Accumulation and Molecular Characterization of cDNAs Encoding Bifunctional GTP Cyclohydrolase II/3,4-Dihydroxy-2-Butanone 4-Phosphate Synthase, Lumazine Synthase, and Riboflavin Synthase in Different Organs of Lycium chinense Plant

Molecules, 2014
Riboflavin (vitamin B2) is the precursor of flavin mononucleotide and flavin adenine dinucleotide—essential cofactors for a wide variety of enzymes involving in numerous metabolic processes.
Pham Anh Tuan, Shicheng Zhao, Jae Kwang Kim, Yeon Bok Kim, Jingli Yang, Cheng Hao Li, Sun-Ju Kim, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Sang Un Park   +9 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Fusarium graminearum mycotoxins and their biosynthetic genes

Mycotoxins, 2012
The plant pathogenic fungus Fusarium graminearum (teleomorph: Gibberella zeae) is a crucial pathogen of major cereal crops and the fungus has taken on greater importance throughout the world. Taking advantage of rapid progress on fungal molecular techniques, we have studied biosynthetic pathways of harmful secondary metabolites of F.
SON, Hokyoung, LEE, Yin-Won
openaire   +2 more sources