Results 101 to 110 of about 202,591 (301)

YUCCA auxin biosynthetic genes are required for Arabidopsis shade avoidance [PDF]

, 2016
Plants respond to neighbor shade by increasing stem and petiole elongation. Shade, sensed by phytochrome photoreceptors, causes stabilization of PHYTOCHROME INTERACTING FACTOR proteins and subsequent induction of YUCCA auxin biosynthetic genes.
Wallace, Andreah D, Palmer, Christine M, Melissa L. Pytlak, Andreah D. Wallace, Covington, Michael F, Müller-Moulé, Patricia, Nozue, Kazunari, Michael F. Covington, Maloof, Julin N, Julin N. Maloof, Pytlak, Melissa L, Stacey L. Harmer, Patricia Müller-Moulé, Harmer, Stacey L, Kazunari Nozue, Christine M. Palmer   +15 more
core   +1 more source

Chromatin-level regulation of biosynthetic gene clusters [PDF]

Nature Chemical Biology, 2009
Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. One new cluster generated monodictyphenone, emodin and emodin derivatives, whereas a second encoded two anti-osteoporosis polyketides, F9775A and F9775B.
Jin Woo, Bok, Yi-Ming, Chiang, Edyta, Szewczyk, Yazmid, Reyes-Dominguez, Ashley D, Davidson, James F, Sanchez, Hsien-Chun, Lo, Kenji, Watanabe, Joseph, Strauss, Berl R, Oakley, Clay C C, Wang, Nancy P, Keller   +11 more
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Plastidial and ER Triacylglycerol Biosynthesis in a Growth Phase-Dependent Manner in the Heterokont Nannochloropsis oceanica

Frontiers in Marine Science, 2020
Though microalgae have been considered the potential resource for lipid production, native strains are unable to meet the industrial demand. Here, we aim to uncover the complex molecular relationship between algal growth and lipid accumulation ...
Dan Huang, Da-Wei Li, Srinivasan Balamurugan, Jian-Wei Zheng, Wan-Jun Liu, Li-Gong Zou, Wei-Dong Yang, Jie-Sheng Liu, Hong-Ye Li   +8 more
doaj   +1 more source

The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum

Journal of Industrial Microbiology & Biotechnology, 2004
The erythromycin-biosynthetic (ery) gene cluster of Aeromicrobium erythreum was cloned and characterized. The 55.4-kb cluster contains 25 ery genes. Homologues were found for each gene in the previously characterized ery gene cluster from Saccharopolyspora erythraea. In addition, four new predicted ery genes were identified.
Igor A, Brikun, Andrew R, Reeves, William H, Cernota, Minh B, Luu, J Mark, Weber   +4 more
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Integrated metabolomic and transcriptomic analysis reveals the biosynthesis mechanism of dihydrochalcones in sweet tea (Lithocarpus litseifolius)

Frontiers in Plant Science
The demand for plant-based, low-calorie natural sweeteners is increasing. Four dihydrochalcones (DHCs), namely phloretin, phlorizin, trilobatin, and sieboldin, have been identified in the leaves of Lithocarpus litseifolius.
Shaojun Ling, Shaojun Ling, Shaojun Ling, Qiongqiong Lin, Qiongqiong Lin, Qiongqiong Lin, Biaofeng Zhou, Biaofeng Zhou, Biaofeng Zhou, Yiye Liang, Yiye Liang, Yiye Liang, Wenji Luo, Wenji Luo, Wenji Luo, Zhao Shen, Zhao Shen, Zhao Shen, Jingshu Wang, Jingshu Wang, Jingshu Wang, Jingwei Niu, Jingwei Niu, Jingwei Niu, Liangjing Qiao, Liangjing Qiao, Liangjing Qiao, Baosheng Wang, Baosheng Wang, Baosheng Wang, Hui Liu, Hui Liu, Hui Liu   +32 more
doaj   +1 more source

An Alkaloid Biosynthetic Gene Bundle in Animals

Journal of the American Chemical Society
Alkaloids include some of the most impactful molecules used in science and medicine. While plant alkaloids are well explored, much less is known about the diverse bioactive alkaloids from the animal kingdom. To solve this problem, we developed a computational method to discover genes that are bundled in chromosomal regions, enabling agnostic discovery ...
Jun Gu Kim, Zhenjian Lin, Vinayak Agarwal, Eric W. Schmidt   +3 more
openaire   +2 more sources

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source